Image_9_C5a/C5aR1 Pathway Is Critical for the Pathogenesis of Psoriasis.JPEG by Quan-you Zheng (713217)

“…Moreover, C5aR1 deficiency significantly decreased IMQ-induced infiltration of plasmacytoid dendritic cells (pDCs), monocytes and neutrophils in psoriatic skin lesions and functions of pDCs, evidenced by the remarkable reduction in the IMQ-induced production of interferon-α (IFN-α) and tumor necrosis factor α (TNF-α), and FMS-like tyrosine kinase 3 ligand (FLT3L)-dependent pDCs differentiation. …”

Image_1_C5a/C5aR1 Pathway Is Critical for the Pathogenesis of Psoriasis.JPEG by Quan-you Zheng (713217)

“…Moreover, C5aR1 deficiency significantly decreased IMQ-induced infiltration of plasmacytoid dendritic cells (pDCs), monocytes and neutrophils in psoriatic skin lesions and functions of pDCs, evidenced by the remarkable reduction in the IMQ-induced production of interferon-α (IFN-α) and tumor necrosis factor α (TNF-α), and FMS-like tyrosine kinase 3 ligand (FLT3L)-dependent pDCs differentiation. …”

Image_3_C5a/C5aR1 Pathway Is Critical for the Pathogenesis of Psoriasis.JPEG by Quan-you Zheng (713217)

“…Moreover, C5aR1 deficiency significantly decreased IMQ-induced infiltration of plasmacytoid dendritic cells (pDCs), monocytes and neutrophils in psoriatic skin lesions and functions of pDCs, evidenced by the remarkable reduction in the IMQ-induced production of interferon-α (IFN-α) and tumor necrosis factor α (TNF-α), and FMS-like tyrosine kinase 3 ligand (FLT3L)-dependent pDCs differentiation. …”

Image_7_C5a/C5aR1 Pathway Is Critical for the Pathogenesis of Psoriasis.JPEG by Quan-you Zheng (713217)

“…Moreover, C5aR1 deficiency significantly decreased IMQ-induced infiltration of plasmacytoid dendritic cells (pDCs), monocytes and neutrophils in psoriatic skin lesions and functions of pDCs, evidenced by the remarkable reduction in the IMQ-induced production of interferon-α (IFN-α) and tumor necrosis factor α (TNF-α), and FMS-like tyrosine kinase 3 ligand (FLT3L)-dependent pDCs differentiation. …”

Image_4_C5a/C5aR1 Pathway Is Critical for the Pathogenesis of Psoriasis.JPEG by Quan-you Zheng (713217)

“…Moreover, C5aR1 deficiency significantly decreased IMQ-induced infiltration of plasmacytoid dendritic cells (pDCs), monocytes and neutrophils in psoriatic skin lesions and functions of pDCs, evidenced by the remarkable reduction in the IMQ-induced production of interferon-α (IFN-α) and tumor necrosis factor α (TNF-α), and FMS-like tyrosine kinase 3 ligand (FLT3L)-dependent pDCs differentiation. …”

Image_6_C5a/C5aR1 Pathway Is Critical for the Pathogenesis of Psoriasis.JPEG by Quan-you Zheng (713217)

“…Moreover, C5aR1 deficiency significantly decreased IMQ-induced infiltration of plasmacytoid dendritic cells (pDCs), monocytes and neutrophils in psoriatic skin lesions and functions of pDCs, evidenced by the remarkable reduction in the IMQ-induced production of interferon-α (IFN-α) and tumor necrosis factor α (TNF-α), and FMS-like tyrosine kinase 3 ligand (FLT3L)-dependent pDCs differentiation. …”

Cardamonin decreased the content of free fatty acids and the activity of CPT-1. by Peiguang Niu (17044532)

Fig 5 - by Te-Hsing Hsu (16973374)

Cardamonin decreased the protein level of Raptor and suppressed lipogenesis and CPT-1. by Peiguang Niu (17044532)

Cdk5 siRNA knockdown decreased Cdk5 activity, diminished WT1 expression and viable cell numbers, and increased cleaved caspase 3 level. by Ya-Li Zheng (454837)

“…After 72h incubation, cells were harvested and submitted to the Western blotting and kinase assay analysis. A&B. Western blots show that Cdk5 siRNA-transfected podocytes successfully decrease Cdk5 expression (upper panel, lane 2) and activity (3rd panel, lane 2 and bar 2, compared to the control siRNA cells, p<0.05), while the expression of cyclin I remain unchanged (2^nd panel). …”

Decrease in the chaining behavior. by Jeonghyeon Yoon (462435)

Serum starvation increases the expression level and prolongs the decay rate of GAS5, and decreases the expression of glucocorticoid-responsive genes. by Hidenori Tani (169942)

Photostimulation of DRN 5-HT neurons <i>in vivo</i>. by Guillaume P. Dugué (620333)

LiCl administered via 0.5% LiCl food pellets for 4 wks decreases pY705-STAT3 (pSTAT3) levels in GFAP-R236H/+ mice. by Christine M. LaPash Daniels (796881)

Fig 5 - by Maryam Banar (3220221)

Mitochondrial dysfunction is driven by decreased mitochondrial dynamics. by Piero Dalle Pezze (622889)

“…(C) Representative live cell images of mitochondrial networks in young (control) and senescent (sen) MRC5 fibroblasts. …”

Cathepsin B and uPAR knockdown decreases Cdk2 activity and the expression of αVβ3 integrin. by Sreelatha Gopinath (238422)

Pharmacodynamic Profile of CCX168 in Healthy Human Volunteers. by Pirow Bekker (392139)

“…CD11b upregulation was diminished in both blood samples from CCX168 subjects with a 10-fold decrease in C5a potency exhibited in the 12-hour samples.…”

Decreased complex V abundance and activity in digitonin-solubilized mitochondria from the <i>icp55Δ</i> strain. by Erine M. Stames (468298)

PGP9.5 and TH immunofluorescense demonstrated colabeling and decreased expression in cardiac nerve bundles of 6-OHDA monkeys. by Valerie Joers (319079)