Bortezomib in combination with the PLK1 inhibitor BI 2536 induces a significant downregulation of the total levels and phosphorylation of Bcr-Abl, a decrease of downstream phosphorylated STAT5 and a caspase-dependent cell death in TKIs-resistant and –sensitive K562 cell lines. by Octavian Bucur (470431)

“…K562 and K562-R cells were treated with 9nM bortezomib and 8nM BI 2536 for 60h, followed by the detection of Bcr-Abl and phosphorylated STAT5. The combined treatment resulted in a marked decrease of the total levels of Bcr-Abl, which correlates with a decrease in the phosphorylation of the downstream STAT5 protein, in both K562 and K562-R cells. β-Actin was used as an internal loading control. …”

RETRACTED ARTICLE: MicroRNA-3194-3p inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by decreasing Wnt/β-catenin signaling through targeting BC... by Bowen Yao (1835059)

Subjects:

Cycloheximide (CHX) treatment decreases production of rRNA transcripts by POLR1 and POLR3. by Martin Selinger (3195987)

“…<p>(A) DAOY cells were treated with CHX (100 μg/ml) for either 6 or 14 hours; for metabolic RNA labelling, 5-EU was added 2 hours before the sample collection. …”

Herceptin down-regulates HER2 receptors and decreases HER3 phosphorylation, but it does not decrease HER2 phosphorylation. by Merel Gijsen (234741)

Herceptin down-regulates HER2 receptors and decreases HER3 phosphorylation, but it does not decrease HER2 phosphorylation. by Merel Gijsen (234741)

Treating obesity decreases TNF-α levels in the obesity-related asthma model. by Joo Young Kim (128707)

Spatial training decreases the association between Ndfip1 and Nedd4 and decreases endogenous Beclin 1 ubiquitination in the hippocampus. by Wei-Lun Hsu (1756123)

“…Endogenous Beclin 1 ubiquitination level is decreased in Nedd4 siRNA-transfected rats (t_1,6 = 5.78, <i>p</i> = 0.001). …”

Treatment of serine protease inhibitor (AEBSF) in the uterus decreases the number of sperm in the oviduct. by Shuai Li (65944)

Does Decreased SNX10 Serve as a Novel Risk Factor in Atrial Fibrillation of the Valvular Heart Disease? - A Case-Control Study by Jianping Yao (5153537)

Vδ2 γδ T cell counts were increased with decreased IFNγ production in peripheral blood of sickle cell disease (SCD) patients compared to controls. by Slimane Allali (341342)

Expression of WT Dyskerin can rescue dysfunctional telomerase in <i>ΔL37</i> cells but not in <i>A353V</i> cells. by Bai-Wei Gu (740949)

Subjects:

Simulated response to Ach at activated NALCN channels and decreased phosphodiesterase (PDE) activity in low glucose. by Leonid E. Fridlyand (2636968)

“…<p>(A) PM potentials (V_p); (B) [Ca²⁺]_c and [Ca²⁺]_ER; (C) Cytoplasmic cAMP and IP₃ concentrations. …”

GSPE decreases the expression of intestinal apical cholesterol transporters, but not in combination with cholestyramine. by Rebecca M. Heidker (812199)

Vanadium(V^IV)–Porphyrin-Based Metal–Organic Frameworks for Synergistic Bimetallic Activation of Inert C(sp³)–H Bonds by Yefei Wang (430888)

“…Herein, by decorating vanadium­(V^IV)–porphyrin into metal–organic frameworks (MOFs) to stabilize the active tertbutyl peroxide radical, we reported a new approach to accomplish inert C­(sp³)–H bond activation by a synergistic bimetallic strategy via a hydrogen atom transfer process under mild conditions. …”

Expression of RBM-26 is disrupted by P80L and L13V missense mutations. by Tamjid A. Chowdhury (14149846)

IL-35 decreased the prevalence of Th17 in CD4+ T cells. by Yin Zongyi (3111660)

“…<p>(A)The ratio of Th17 in CD4+ T cells. (B) Representative diagram showing Th17’s ratio in CD4+ T cells was significantly decreased in the IL-35 group compared to that in the control group (0.3% vs. 7.2% on day 5, P<0.01). …”

Kaplan Meier curves of survival of patients with severe sepsis/septic shock classified in function of a decrease of procalcitonin levels higher (continuous line) or lower (dashed line) than 50% from day 0 to 5 of ICU stay. by Juan-Jesús Ríos-Toro (3907732)

Biallelic mutations in human <i>HBS1L</i> lead to Hbs1L deficiency and decreased Pelota protein. by Amy E. O’Connell (6288401)

The decrease of <i>CLB1</i> expression in the <i>puf5</i>Δ mutant contributes to the growth defect of the <i>puf5</i>Δ <i>clb2</i>Δ double mutant. by Megumi Sato (4116994)

Effect of decreased endogenous betaglycan expression on metanephric development and glomerulogenesis. by Kenneth A. Walker (280683)