An in vivo murine calvarial model of particle-induced osteolysis demonstrates Cobalt-alloy debris co-challenge with TLR4 induces osteolysis but not more than Cobalt alloy alone. by Lauryn Samelko (424639)

“…<p>C57BL/6 12 wk old male mice either received (n = 5 per group): (1) sham-surgery (sterile PBS), (2) 2 mg/mouse calvaria of endotoxin-free Cobalt-alloy particles, (3) 5 μg/mL LPS or (4) Cobalt-alloy/LPS+. 10 days later, calvaria were retrieved and analyzed by microCT. …”

Pituitary genomic expression profiles of steers are altered by grazing of high vs. low endophyte-infected tall fescue forages by Qing Li (84975)

“…To identify candidate regulatory mechanisms, we compared the global and selected targeted mRNA expression patterns of pituitaries collected from beef steers that had been randomly assigned to undergo summer-long grazing (89 to 105 d) of a high-toxic endophyte-infected tall fescue pasture (HE; 0.746 μg/g ergot alkaloids; 5.7 ha; <i>n</i> = 10; BW = 267 ± 14.5 kg) or a low-toxic endophyte tall fescue–mixed pasture (LE; 0.023 μg/g ergot alkaloids; 5.7 ha; <i>n</i> = 9; BW = 266 ± 10.9 kg). …”

Water quality and survival rate of Rhamdia quelen fry subjected to simulated transportation at different stock densities and temperatures by Fábio Bittencourt (4651879)

“…Temperature and time had a significant influence on ammonia, pH, electrical conductivity, and dissolved oxygen levels, and fish died after 12 hours of transportation simulation when kept at 20 and 25ºC. The density directly affected the water quality parameters, such as the increase in electrical conductivity and turbidity, and decrease in dissolved oxygen and pH at the density of 60 fish 5 L-1. …”

Anisomycin infusion in the olfactory bulb during the spaced learning blocked improvements in performance and increase in neurogenesis. by Florence Kermen (362513)

“…Conditioned saline-infused (saline C) animals learned the task as shown by the decrease in latency and remembered it after 5 days. …”

Silencing of <i>SREB</i> using RNA interference. by Amber J. Marty (761758)

“…<p>(<b>A-C</b>) Quantitative real-time PCR analysis demonstrated a 1.8–2.5-fold decrease in <i>SREB</i> transcript and derepression of <i>SID1</i> (2.9 6.2-fold increase) and <i>HAPX</i> (1.7 3.2-fold increase) in <i>SREB</i> RNAi strains #6 and #7 compared to controls (GFP reporter, empty vector, GFP-RNAi). …”

<i>Smed-not1</i> is expressed in CNS and throughout the parenchyma in an irradiation-sensitive manner. by Jordi Solana (499882)

“…<i>Smed-not1</i> signals are detected as a broad staining pattern in non-irradiated animals (A, top panel, non irrad), and decrease 3 days (A, middle panel, irrad 3d) and 5 days (A, bottom panel, irrad 5d) after lethal irradiation. …”

DNA Methylation as a Biomarker for Cardiovascular Disease Risk by Myungjin Kim (60778)

“…This may reflect a reduced systemic remethylation capacity, which would be expected to cause decreased genomic DNA methylation in peripheral blood leukocytes (PBL).…”

Phenological shifts in lake ice cover across the Northern Hemisphere: A glimpse into the past, present, and the future of lake ice phenology by AMAN BASU (17008314)

Data_Sheet_1_A Global Survey on Changes in the Supply, Price, and Use of Illicit Drugs and Alcohol, and Related Complications During the 2020 COVID-19 Pandemic.docx by Ali Farhoudian (11239533)

“…With respect to changes in use patterns, an increase in alcohol (71.7%), cannabis (63.0%), prescription opioids (70.9%), and sedative/hypnotics (84.6%) use was reported, while the use of amphetamines (59.7%), cocaine (67.5%), and opiates (58.2%) was reported to decrease overall.…”

Supplementary Material for: Combined Pancreatic Islet-Lung-Liver Transplantation in a Pediatric Patient with Cystic Fibrosis-Related Diabetes by Klee P. (5115737)

“…HbA1c decreased from 7.3% (57.4 mmol/mol) to 5.9% (41.0 mmol/mol). …”

Supplementary Material for: Effectiveness and Cost-Effectiveness of Dialectical Behaviour Therapy for Self-Harming Patients with Personality Disorder: A Pragmatic Randomised Contro... by Priebe S. (4133113)

“…The economic analysis revealed a total cost of a mean of 5,685 GBP (6,786 EUR) in DBT compared to a mean of 3,754 GBP (4,481 EUR) in TAU, but the difference was not significant (95% CI –603 to 4,599 GBP). …”

Enhanced megakaryopoiesis and thrombopoieisis after DT-mediated MK ablation. by Catherine Angénieux (145933)

“…<p>F1 iDTR x PF4-Cre mice received 100 ng/day DT or saline for 4 days (first injection on day 1). PLT counts decreased during the following days and PLT rebound occurred between days 7 and 8. …”

IGF-II promotes an intracellular and an extracellular fibrotic environment. by Sara M. Garrett (8038460)

“…N = 5–10. *p<0.05, **p<0.01, ***p<0.001 by 1-way ANOVA with Dunnett’s multiple comparison test. …”

Table_1_Association of Variability and Pharmacogenomics With Bioequivalence of Gefitinib in Healthy Male Subjects.docx by Hong Zhang (25820)

“…The median maximum plasma concentration (T_max) was 4–5 h, and the mean elimination half-life (t_1/2) was 18–26 h. …”

Recombinant PLTP induced FLS proliferation and cytokine production independently of its lipid transfer ability. by Rachel Audo (96127)

“…(<b>B</b>) Blockade of PLTP decreased the effect of rhPLTP on FLS proliferation. …”

Neurons are uncorrelated during PABA and exhibit Poisson-like irregularity. by Nigel Stepp (683934)

“…<p>A) Neuronal firing is weakly correlated during ongoing activity in awake monkeys that display neuronal avalanches in the local field potential (LFP) Distributions of pair-wise correlation coefficients of firing in the pre-motor cortex of two awake monkeys, S1 (1.2 Hz mean rate) and S2 (5.2 Hz mean rate). For details see the <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004043#sec004" target="_blank">Materials and Methods</a> section and [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004043#pcbi.1004043.ref001" target="_blank">1</a>, <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004043#pcbi.1004043.ref027" target="_blank">27</a>]. …”

Effect of RASFib on B cell survival. by Marta Benito-Miguel (316481)

“…Representative flow cytometry dot-plots of B cells stained with JC-1 or with 7AAD/Annexin V. When compared with freshly isolated B cells, viability of B cells cultured in plain medium for 6 days is dramatically decreased. …”

Poly(lactic-co-glycolic) acid nanoparticles localize in vesicles after diffusing into cells and are retained by intracellular traffic modulators supplementary figures by Neha Singh (129019)

Image2_Ghrelin is essential for lowering blood pressure during torpor.jpg by Kazuma Matsui (1368618)

“…We have previously reported that ghrelin, an orexigenic hormone, has a hypothermic effect and is essential for the induction and maintenance of torpor. …”

Image1_Ghrelin is essential for lowering blood pressure during torpor.jpeg by Kazuma Matsui (1368618)

“…We have previously reported that ghrelin, an orexigenic hormone, has a hypothermic effect and is essential for the induction and maintenance of torpor. …”