Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress by Béatrice Chambraud (3371201)

“…</p> <p><b>Abbreviations:</b> AD: Alzheimer disease; AKT/protein kinase B: AKT serine/threonine kinase; ALP: Autophagy-lysosomal pathway; ATG: autophagy-related; BafA₁: bafilomycin A₁; CQ: chloroquine; CTSD: cathepsin D; DIV: days in vitro; DRG: dorsal root ganglion neurons; Dox: doxycycline; DNAJC5: DnaJ heat shock protein family (Hsp40) member C5; EL: empty lentiviral vectors; ENO2/NSE: enolase 2, gamma neuronal; FKBP4/FKBP52: FKBP prolyl isomerase 4; FTLD-Tau: frontotemporal lobar degeneration with Tau pathology; GFP: green fluorescent protein; LAMP1: lysosomal associated membrane protein 1; LDH: lactate dehydrogenase; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAPT/Tau: microtubule associated protein tau; MTT: tetrazolium salt; NFTs: neurofibrillary tangles; RPE-1: retinal pigment epithelial cells; shRNA: small-hairpin ribonucleic acid; SQSTM1/p62: sequestosome 1; SD: standard deviation; SEM: standard error of the mean; SH-SY5Y: human neuroblastoma cells; Sh1 or Sh2: Lentiviral shRNA vectors inducing FKBP4 decrease; SH-52GFP: MAPT/Tau-inducible SH-SY5Y cell line constitutively expressing FKBP4-GFP; TUBB3/βIII tubulin: tubulin beta 3 class III; UPS: ubiquitin-proteasome system</p>…”

Effect of MA-5 on sIBM myoblasts. by Yoshitsugu Oikawa (9721356)

TLR4 receptor inhibition decreased ranibizumab and aflibercept mediated CCL2, CCL5, and CX3CL1 mRNA and protein levels in HCAECs. by Clare Arnott (2557705)

Dilution coefficient (τ) at 25°C and 37°C for 5 suspending media compared to that of a physiological value of τ = 1. by Chadapust J. Sudsiri (14670602)

cAMP concentration, adenylyl cyclase 6 expression, and V2 receptor expression in renal medulla. by Lucas H. Oronel (8525697)

<i>Bahd1</i>-knockout mice display decreased weight and fat mass and lower cholesterol, glucose and leptin levels. by Goran Lakisic (2551717)

The expression of 5-hmC was decreased in ESCC tissues and cell lines. by Xuejiao Shi (1684186)

Decreased expression levels of the MYO6 protein in <i>ksv</i> mice. by Yuta Seki (4385833)

“…Green and red signals are co-localized in the perinuclear region. Scale bar = 5 μm. B and C. Expression analysis of MYO6 protein in <i>Myo6</i>^+/+ (B) and <i>Myo6</i>^-/—null mutant (C) mice using the anti-MYO6 (N-ter) antibody. …”

Fig 5 - by Changhyun Lim (8693979)

fAd and gAd decrease TER value in an AMPK-dependent manner in SMG-C6 cells. by Chong Ding (410804)

Fig 5 - by Kun Qian (62517)

Osr1 heterozygous mice experienced decreased bile acid synthesis in the liver. by Ernest C. Lynch (12769954)

“…(C). Combined results of Osr1 male and female mice show a decreased trend of hepatic bile acid compared to WT mice. …”

Photostimulation of DRN 5-HT neurons <i>in vivo</i>. by Guillaume P. Dugué (620333)

Pharmacological inhibition of Hsp90 with GdA decreased apoptosis and caspase activity of <i>C. albicans.</i> by BaoDi Dai (307154)

Acid wash decrease, but do not attenuate sCT mediated prolonged cAMP and β-arrestin signaling. by Kim Vietz Andreassen (317792)

Decreased tumor size <i>in vivo</i> is achieved by depletion of miR-21 <i>in vitro</i>. by Sara E. Martin del Campo (683602)

The <i>AtTIFY10a/b</i> knockout mutant <i>Arabidopsis</i> showed decreased alkaline tolerance at the seed germination stage. by Dan Zhu (139675)

HDL modification by acrolein leads to decreased selective uptake efficiency of HDL-COE. by Alexandra C. Chadwick (306282)

Fig 5 - by Kenichi Kiyomoto (12709675)

Fig 5 - by Jiahang Zhang (6420110)