Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

Development of a CRISPR/Cas-Based Detection Platform for Tracking Decreased Susceptibility to Cephalosporins in Neisseria gonorrheae by Ziyuan Zhao (2889005)

Subjects:

Decreases in locomotor responses to a single METH injection in <i>Ptprz</i>-KO mice. by Akihiro Fujikawa (122649)

Excessive LF4A kinase activity shortens cilia and decreases IFT. by Yu-Yang Jiang (7036916)

Hedgehog and steroidogenic pathway genes are decreased in <i>Gli3</i>^<i>XtJ</i> testes. by Anbarasi Kothandapani (8934590)

Results on the trimmed datasets with a decreasing number of papers per author available for training and testing. by Leonard Bauersfeld (16475015)

Table_1_A point mutation in MC06g1112 encoding FLOWERING LOCUS T decreases the first flower node in bitter gourd (Momordica charantia L.).xlsx by Jian Zhong (329110)

“…A point mutation (C277T) in MC06g1112, which results in a P93S amino acid mutation between parental lines, may be responsible for decreasing FFN in bitter gourd. …”

Risk assessment for hospital admission in patients with COPD; a multi-centre UK prospective observational study by Jilles M. Fermont (3746068)

“…Poorer performance of SPPB was associated with both higher rate (IRR 1.08 per 1 point decrease, 95% CI 1.01 to 1.14) and increased length of stay (IRR 1.18 per 1 point decrease, 95% CI 1.10 to 1.27) for hospitalised AECOPD. …”

Significantly decreased adhesion to host cells by the Δ<i>tad123</i> mutant (A) and time-dependent recovery (B). by Tra-My Duong-Nu (7300970)

Both oral arginine and citrulline protect against eCM. by Irene Gramaglia (6439613)

Decreased protection of NMT in <i>ACBD6</i>-deficient cells. by Eric Soupene (64584)

Decline for a Delicacy: are decreasing numbers of Yellow-eyed penguins on Stewart Island a result of commercial oyster dredging? by Thomas Mattern (7910438)

A possible explanation for a nonlinear decline in populations could be a decrease in active AMP concentration over time due to degradation. by Alexandro Rodríguez-Rojas (326213)

RhoA gene expression and activity are impacted with increased intracellular 5HT. by Celeste M. Sheftel (9557588)

“…<p><b>A.</b><i>RhoA</i> mRNA expression is significantly upregulated with FLX and 5HTP compared to controls and is significantly decreased in FLX + MDC. …”

General procedure for the synthesis of A and A-c1. by Xueqin lu (22250795)

Divergence from transmitted/founder (TF) virus increases during ART-naïve infection and decreases on treatment. by Kelsie Brooks (8928044)

Increasing and decreasing temperature trends in <i>M</i>. <i>peregrina</i> habitats at 95% confidence level. by Hossein Piri Sahragard (19226096)

Population dynamics modeling of split^50cM <i>ClvR</i> V1 drive introduced at different release percentages, and an example illustrating the role that LOF alleles play in... by Georg Oberhofer (3401438)

“…In all panels in which fitness costs are present <b>(D-F)</b> there is a 50% release of WT in generation 150. Allele and genotype frequencies after this point are indicated with dotted lines. …”

Predicted distribution of boat sizes, given a 10 percentage point increase in the probability of interception. by Katherine Hoffmann Pham (11619125)