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Belinostat decreases both male and female bladder weights in transgenic superficial bladder cancer mice
Published 2011“…Normal non-transgenic mouse bladders weigh approximately 10.0 mg at the same age, and Ha-transgenic mice with superficial bladder cancer have a 3 fold and higher bladder weight. , Male belinostat-treated mice (n = 4, 327.5 mg average weight) showed a two-fold decrease (50%, p = 0.03) in bladder weight versus control (n = 4, 652.5 mg average weight). , Female belinostat-treated mice (n = 5, 34.0 mg average weight) showed a 36% decrease (p = 0.04) in bladder weight versus control (n = 6, 53.3 mg average weight).…”
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Gene ontology biological processes overrepresented among genes exhibiting decreased expression in human psoriasis.
Published 2011“…<p>A total of 3540 transcripts were identified as significantly decreased in psoriatic plaques obtained from human patients relative to normal skin obtained from control subjects (FDR-adjusted P<0.05 and log<sub>2</sub>-transformed fold-change less than -0.50). …”
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The proportion of Treg decreases and the proportion of Th17 cells increases, but the absolute numbers of both are increased.
Published 2015“…<p><b>(A and B)</b> At the time of bile ductal obstruction, flow cytometry analysis showed that the percentage of Tregs decreased but Th17 increased in the liver of the RRV group compared to the saline group. …”
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The <i>rcan-1</i> rearrangement allele decreases expression of <i>rcan-1</i>.
Published 2020“…Cyan: p<0.01, log<sub>2</sub>(Fold Change) < -1. (The list of differential expressed genes with significance are available in <b><a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008606#pgen.1008606.s018" target="_blank">S5 Table</a></b>). …”
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