Image_2_Orthopedic Surgery Triggers Attention Deficits in a Delirium-Like Mouse Model.TIFF by Ravikanth Velagapudi (7880072)

“…Inattention is often reported in the clinical diagnosis of delirium, however limited attempts have been made to study this cognitive domain in preclinical models. Here we implemented the 5-choice serial reaction time task (5-CSRTT) to evaluate attention in a clinically relevant mouse model following orthopedic surgery. …”

Video_2_Orthopedic Surgery Triggers Attention Deficits in a Delirium-Like Mouse Model.MOV by Ravikanth Velagapudi (7880072)

“…Inattention is often reported in the clinical diagnosis of delirium, however limited attempts have been made to study this cognitive domain in preclinical models. Here we implemented the 5-choice serial reaction time task (5-CSRTT) to evaluate attention in a clinically relevant mouse model following orthopedic surgery. …”

Image_2_Orthopedic Surgery Triggers Attention Deficits in a Delirium-Like Mouse Model.TIFF by Ravikanth Velagapudi (7880072)

“…Inattention is often reported in the clinical diagnosis of delirium, however limited attempts have been made to study this cognitive domain in preclinical models. Here we implemented the 5-choice serial reaction time task (5-CSRTT) to evaluate attention in a clinically relevant mouse model following orthopedic surgery. …”

Arrested Catalysis: Controlling Kumada Coupling Activity via a Redox-Active N-Heterocyclic Carbene by Andrew G. Tennyson (1419994)

“…Addition of 2 equiv of cobaltocene (with respect to <b>3a</b>) to the coupling reaction with bromotoluene caused a decrease in catalytic activity (from 4.7 × 10⁻⁵ to 2.7 × 10⁻⁶ s⁻¹), which was attributed to the conversion of <b>3a</b> to an arrested state. …”

Arrested Catalysis: Controlling Kumada Coupling Activity via a Redox-Active N-Heterocyclic Carbene by Andrew G. Tennyson (1419994)

“…Addition of 2 equiv of cobaltocene (with respect to <b>3a</b>) to the coupling reaction with bromotoluene caused a decrease in catalytic activity (from 4.7 × 10⁻⁵ to 2.7 × 10⁻⁶ s⁻¹), which was attributed to the conversion of <b>3a</b> to an arrested state. …”

Arrested Catalysis: Controlling Kumada Coupling Activity via a Redox-Active N-Heterocyclic Carbene by Andrew G. Tennyson (1419994)

“…Addition of 2 equiv of cobaltocene (with respect to <b>3a</b>) to the coupling reaction with bromotoluene caused a decrease in catalytic activity (from 4.7 × 10⁻⁵ to 2.7 × 10⁻⁶ s⁻¹), which was attributed to the conversion of <b>3a</b> to an arrested state. …”

Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects by Xiaopeng Peng (9136955)

“…Importantly, the combination of <b>NT-6</b> with a small-molecule PD-L1 inhibitor NP-19 decreased tumor burden significantly (TGI% = 77.6%). …”

Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects by Xiaopeng Peng (9136955)

“…Importantly, the combination of <b>NT-6</b> with a small-molecule PD-L1 inhibitor NP-19 decreased tumor burden significantly (TGI% = 77.6%). …”

Effect of the W501R substitution on the ability of HCV helicase to unwind DNA. by Paola J. S. Provazzi (835454)

“…The reactions were prepared containing 25 mM MOPS, 1.25 mM MgCl₂, 5 nM Cy5-substrate; 1mM ATP, 0.05 mM DTT, 0.005 mg/mL BSA, 0.001% Tween20, and enzymes NS3h_1b (con1), NS3h_3a (wt) and NS3h_3a (W501R) at indicated concentrations.…”

CRISPRi knockdowns of candidate genes and phenotypic characterization of GBS lacking MrvR in amniotic fluid, rich media, and biofilm-promoting growth conditions. by Allison N. Dammann (10271174)

“…For each gene, the number indicates the targeted nucleotide; the protospacer sequence is shown in parentheses (<b>B</b>). A qPCR-based multiplex CRISPRi screen using knockdowns of all five candidate genes revealed decreased fitness in amniotic fluid compared to tryptic soy (TS) broth (<b>C</b>); black columns show the competition index of strains bearing individual targeting protospacer plasmids, while red columns show pooled results from both targeting plasmids for each gene. …”

Effect of ibuprofen (IBU) on carbonic anhydrase IX (CA IX) expression. by Katarina Grossmannova (7543517)

“…<p>HCT116, RKO, FaDu and UM-22A cells cultured in monolayers in hypoxic conditions (1% O2) were lyzed at 24h and 48h of treatment with 0.5 mM IBU, 1 mM IBU, or DMSO as control (0 mM). …”

Nanocrystal [Ti₁₄C₁₃] to Metallocarbohedrene [Ti₈C₁₃]:  Structural Principles and Mechanism by Ian Dance (2240116)

“…This sequence of six photodissociations of Ti atoms is significant because it involves the transformation of a fragment of a non-molecular lattice structure to a molecular cluster structure and the formation of six C−C bonds on the surface. …”

Temporal Trends of Great Lakes Legacy Contaminants: Ecological and Biological Considerations Applying the Age-Trend Model by James J. Pagano (2043490)

“…Our research revealed that select legacy contaminant groups (∑PCBs, ∑DDTs, ∑chlordanes, and ∑5PBDEs) have similar <i>t</i>_1/2 and <i>k</i>₂ values across the Great Lakes, with the exception of both Lake Erie sites and the Lake SuperiorKeweenaw Point site. …”

PCR targeting three regions within the prophage island found to be downregulated in Δ<i>mrvR</i>. by Allison N. Dammann (10271174)

Year and holiday effects. by Wael Ghada (11719000)

Fig 6 - by Patrik Galeta (16015459)

Fig 7 - by Patrik Galeta (16015459)

Effects of bortezomib/venetoclax on the growth suppression of sLCL 381 xenografts in SCID mice. by Kam Pui Tam (19746865)

GLAST-Cre⁺ cells from the GER mitotically regenerate IPhCs. by Tomokatsu Udagawa (11675636)

“…<p>Representative images of apical turns are shown. (A, C) Cryosections of P4 and P7 control cochleae with Fabp7⁺ Sox2⁺ IPhCs (arrowheads). …”

Enzymatic Mechanism of Human Apurinic/Apyrimidinic Endonuclease against a THF AP Site Model Substrate by Sophia T. Mundle (303078)

“…Therefore, it is essential to accurately and directly characterize the enzymatic mechanism of AP endo. Here we describe specifically designed double-stranded DNA oligomers containing tetrahydrofuran (THF) with a 5′-phosphorothioate linkage as the abasic site substrate. …”