The Interference of Notch1 target Hes1 affects cell growth, differentiation and invasiveness of glioblastoma stem cells through modulation of multiple oncogenic targets by Cenciarelli, Carlo

“…In the last decade Stat3 has gained attention as therapeutic target in cancer but there is not yet any approved Stat3-based glioma therapy. Herein, we report that exposure to a Stat3/5 inhibitor, induced apoptosis either in shHes1-CSC or control cells. …”
Get full text

Electrical characteristics and density of states of thin-film transistors based on sol-gel derived ZnO channel layers with different annealing temperatures by Wang S.

Get full text
Get full text

Computational approach to unravel the impact of missense mutations of proteins (D2HGDH and IDH2) causing D-2-hydroxyglutaric aciduria 2. by Thirumal Kumar, D

“…The D-2-HGA includes two subtypes: type I and type II caused by the mutations in D2HGDH and IDH2 proteins, respectively. In this study, we studied six mutations, four in the D2HGDH (I147S, D375Y, N439D, and V444A) and two in the IDH2 proteins (R140G, R140Q). …”
Get full text
Get full text

Effect of hyperglycemia on EPCs function and regenerative ability by Hendawi, Hadeel Khalil

“…This research aims to test the EPC subtype blood outgrowth endothelial cells (BOECs) and their ability to survive and function under chronic hyperglycemic conditions. For that, we studied BOECs viability, response to shear stress, angiogenesis ability, and barrier function under normoglycemic (5.5mM) and hyperglycemic (25mM) conditions. …”
Get full text
Get full text

Specific Bioactive Compounds from Ginger, Tea, and Apple Prevent Diabetes-Related Cataract Via Inhibition of Aldose Reducatse by Ahmedna, Mohamed

“…The activity of aldose reductase was found to increase 5 folds at 10 mM from day 1 to day 4, whereas at 25, 50 and 100 mM concentrations of glucose the AR activity was increased to almost 2 folds. …”
Get full text
Get full text

Increased cellular protein modification by methylglyoxal activates endoplasmic reticulum-based sensors of the unfolded protein response by Xue, Mingzhan

Get full text
Get full text
Get full text

Superior photocatalytic activity of Cu doped NiWO4 for efficient degradation of benzene in air even under visible radiation by Tri N.L.M.

“…This was because Cu effectively acted as novel dopant, which not only affected valence band (VB) top and conduction band (CB) bottom of NiWO4 but also formed a medium energy level between CB and VB of the NiWO4 to decrease its energy band gap and electron-hole recombination rate. …”
Get full text
Get full text

Trends in prevalence of depression and anxiety symptoms and effects of sociodemographic variables before and after the first wave of COVID-19 in Qatar by Khaled, Salma M.

“…The data for 2020/21 showed a 35.1% and 29.2% decrease in depression and anxiety symptoms scores compared to pre-pandemic years (2017/2018) after adjusting for sociodemographic factors. …”
Get full text
Get full text

Roadmap toward energy-positive upfront nitrogen removal process in baseload LNG plant by Mkacher, Hajer

“…The results show that UNrem of 87.5% from the NG feed can reduce the total power requirements by 0.24%, increase the production flow rate by 4.4%, and decrease the exergy losses by 0.23% compared with the base case. …”
Get full text
Get full text

Modeling of dual-metal Schottky contacts based silicon micro and nano wire solar cells by Rabbani, M. Golam

Get full text
Get full text

25-Hydroxyvitamin D serum levels inversely correlate to disease severity and serum C-reactive protein levels in patients with hidradenitis suppurativa by Moltrasio, Chiara

“…Subsequently, Guillet et al.5 described an association between vitamin D deficiency and HS severity, also reporting a significant decrease of the inflammatory nodules in patients supplemented with vitamin D. …”
Get full text
Get full text
Get full text

Antibiotic Prescription Patterns for Upper Respiratory Tract Infections in Outpatient Qatari Population in the Private Sector by Butt, Adeel Ajwad

“…During the study period, health insurance was limited to Qatari nationals. We excluded topical antibiotics. We also retrieved data on prescriber’s specialty as listed with the licensing authority. …”
Get full text
Get full text

Corporate governance and cost of debt financing: Empirical evidence from Canada by Ghouma, Hatem

Get full text
Get full text

Effect of mobile text messages on antiretroviral medication adherence and patient retention in early HIV care: An open-label, randomized, single center study in south Florida by Sherman, Elizabeth M.

“…Background People with HIV (PHIV) with limited access to health services often experience suboptimal antiretroviral therapy (ART) adherence. We investigated whether a daily text messaging intervention improves ART adherence and retention in early HIV care in PHIV in a south Florida hospital-based clinic. …”
Get full text
Get full text

Integrated planning of spare parts and service engineers with partial backlogging by Rahimi-Ghahroodi, S.

“…In a numerical study, we show that for problems with more than five types of spare parts it is preferable to use approximate evaluations as they become significantly faster than exact evaluation. …”
Get full text
Get full text

Evacuated tube heat pipe solar collector for Encontech engine-driven reverse osmosis solar desalination by Takalkar, Gorakshnath

“…Both energetic and exergetic efficiencies exhibit upper values at A co/A abs ratio up to 1. Further increment in this ratio up to 3 resulted in a decrease in the efficiency of the ETHPSC.…”
Get full text
Get full text

Pharmacologic inhibition of hypoxia-inducible factor (HIF)-hydroxylases ameliorates allergic contact dermatitis by Manresa M.C.

“…Background When an immune cell migrates from the bloodstream to a site of chronic inflammation, it experiences a profound decrease in microenvironmental oxygen levels leading to a state of cellular hypoxia. …”
Get full text
Get full text

Higher egg consumption associated with increased risk of diabetes in Chinese adults - China Health and Nutrition Survey. by Wang, Yue

“…The association between egg consumption and diabetes is inconclusive. We aimed to examine the association between long-term egg consumption and its trajectory with diabetes in Chinese adults. …”
Get full text
Get full text

Epidemiology of herpes simplex virus type 2 in Europe: systematic review, meta-analyses, and meta-regressions by Alareeki, Asalah

“…HSV-2 detection in genital herpes cases was 1.21-fold (95% CI: 1.10–1.32) higher in men compared to women and decreased by 1% per calendar year. …”
Get full text
Get full text
Get full text

Nanoclay compatibilization of phase separated polysulfone/polyimide films for oxygen barrier by Ammar, Ali

“…Herein, we quantify the effect of a nanoclay, Cloisite 30B on the phase separated blend film morphology compatibilization of PSF/PI and associated changes in its mechanical properties and film surface energy. …”
Get full text
Get full text