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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Mutation of the two residues in NLuc revealed a decreased but stable activity of the R162A, but not Q32A, mutant NLuc in live cell and in vitro assays performed using lysates prepared from cells expressing the proteins and with the furimazine substrate. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Here, we dissect the mechanism underlying the increased binding affinity of the N501Y mutant for ACE2 using molecular dynamics (MD) simulations of the available ACE2-S1-RBD complex structure (6M0J) and show a prolonged and stable interfacial interaction of the N501Y mutant S1-RBD with ACE2 compared to the wild type S1-RBD. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Chemical biology approaches using small molecule inhibitors targeting specific signaling pathways are useful tools to dissect the molecular mechanisms governing stem cell differentiation and for their possible use in therapeutic interventions. …”
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Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex
Published 2022“…This sentence previously stated:</p><p dir="ltr">“Representative trajectory movies of the 10 ns simulations were prepared from 5,000 trajectory snapshots (50 snapshots/ns) generated using VMD Movie Maker Tool (Humphrey et al., 1996) and compiled using Fiji distribution of ImageJ software (Schindelin et al., 2012) at a frame rate of 300 fps.”…”
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Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals ov...
Published 2023“…At the 7th month, there was a significant decline in antibody responses among VN individuals, but not NI individuals, with a minimum decrease of 3.7-fold (p < 0.001). Among VN individuals, anti-S1 IgA levels began to decrease significantly (1.4-fold; p = 0.007) after two months, and both NtAb and S-RBD IgG levels began to decline significantly (NtAb: 2.0-fold; p = 0.042, S-RBD IgG: 2.4-fold; p = 0.035) after three months. …”
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Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals ov...
Published 2023“…At the 7th month, there was a significant decline in antibody responses among VN individuals, but not NI individuals, with a minimum decrease of 3.7-fold (p < 0.001). Among VN individuals, anti-S1 IgA levels began to decrease significantly (1.4-fold; p = 0.007) after two months, and both NtAb and S-RBD IgG levels began to decline significantly (NtAb: 2.0-fold; p = 0.042, S-RBD IgG: 2.4-fold; p = 0.035) after three months. …”
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Internet Searches for Medical Symptoms Before Seeking Information on 12-Step Addiction Treatment Programs: A Web-Search Log Analysis
Published 2019“…<h3>Background</h3><p dir="ltr">Brief intervention is a critical method for identifying patients with problematic substance use in primary care settings and for motivating them to consider treatment options. …”
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An additive manufacturing approach based on electrohydrodynamic printing to fabricate P3HT:PCBM thin films
Published 2023“…We report here on the fabrication of poly(3-hexylthiophene): phenyl-C61-butyric acid methyl ester (P3HT:PCBM) thin films through the electrohydrodynamic atomization (EHDA) process and its integration as absorber layer for organic solar cells. …”
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The impact of COVID‐19 pandemic lockdown on smoking habits and lifestyle: A cross‐sectional study
Published 2023“…</p><h3>Methods</h3><p dir="ltr">A cross‐sectional online survey was designed using the Google Forms service and distributed by social media platforms. …”
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Land surface temperature responses to land use dynamics in urban areas of Doha, Qatar
Published 2024“…This study investigates the impact of land use and land cover changes on summer and winter LSTs in Doha and Al Dayeen municipalities of Qatar, spanning from the years 2000 to 2023, using remote sensing techniques and Geographic Information Systems (GIS). …”
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Evidence-based safety education and training for traffic injury prevention
Published 2015“…Bicycle skill training for children and youth may increase their safety knowledge, but not necessarily improve their behavior or decrease their injury rates. Non-legislative interventions were found effective for increasing observed helmet use among bicyclists. …”
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An Experimental Investigation of the Effects of Dressing and Grinding Parameters on Sustainable Grinding of Inconel 738 Used for Automated Manufacturing
Published 2023“…In other words, increasing the dressing feed rate during dressing of the grinding wheel using a multipoint dresser makes a finer wheel surface topography and as a result decreases the surface roughness of the ground workpiece compared to a single-edge dresser. …”
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Design and analysis of PV fed high-voltage gain DC-DC converter using PI and NN controllers
Published 2022“…The entire globe is now focused on generating power using solar photovoltaic (SPV) cells. The SPV is generating the DC power, by using power converters to satisfy the load requirement. …”
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The Triple “S” Impact of COVID-19: Nationwide Evidence of the Impact of the Stress Associated With Restrictive Measures on Substance Use, Sleep, and Social Connectedness in Qatar...
Published 2023“…Of tobacco users in our sample, 36% reported increased tobacco use since the start of home confinement, while 41.6% of alcohol users reported decreased alcohol use. …”
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Two-stage optimisation for malachite green removal using activated date pits
Published 2022“…The surface areas and maximum malachite green adsorption capacities of the natural date stone and the phosphoric acid–treated date stone were 86 and 909 m2/g, respectively, and maximum malachite green adsorption capacities were 31.5 and 64.7 mg/g, respectively. …”
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Use of Carbide Derived Carbon in Water Treatment and Thermal Fluids Applications
Published 2021“…More than 26% enhancement in thermal conductivity of thermal fluids was obtained by using 0.3 wt% CDC. These findings indicate a promising potential of using CDC for heat transfer applications such as heat exchangers and district cooling units.…”
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
Published 2023“…Decreased formation and increased clearance of MG-derived AGEs may be associated with healthy aging in the HSA-mUCP1 mouse.…”
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
Published 2023“…Decreased formation and increased clearance of MG-derived AGEs may be associated with healthy aging in the HSA-mUCP1 mouse.…”
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Land surface temperature responses to land use dynamics in urban areas of Doha, Qatar
Published 2024“…This study investigates the impact of land use and land cover changes on summer and winter LSTs in Doha and Al Dayeen municipalities of Qatar, spanning from the years 2000 to 2023, using remote sensing techniques and Geographic Information Systems (GIS). …”