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Losartan increased ACE-2 expression, while SARS-CoV-2 spike protein decreased ACE-2 expression in hACE2 brains.
Published 2024“…<p>hACE2 KI mice were treated only with Losartan or intravenously injected with SARS-CoV-2 spike protein (SP, 4 μg/ animal) with or without Losartan (10 mg/kg body weight) for 2 weeks. …”
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Brain uptake of [<sup>3</sup>H]mannitol in 2-, 8-, 12-, and 24-month-old mice.
Published 2023Subjects: -
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