Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Heterogeneous distribution of 5-HTR subtypes as measured by PET. by Yukiko Hori (299784)

Subjects:

Cardamonin decreased the protein expression of lipogenic proteins. by Peiguang Niu (17044532)

miR-450a decreases TMEM182 by directly targeting 3'-UTR. by En-Wei Hsing (154990)

Machine Learning Model Performance Sorted by Decreasing MAE. by Renan N. D. Almeida (9265283)

Represents the levels of biomarkers as baseline and follow up in placebo and cholecalciferol group. by Jaskiran Kaur (160829)

Crosslinking decreases the alignment of fibers associated with individual cells migrating out of spheroids. by Michael Pamonag (12295175)

VPA decreases cell proliferation. by Muriel Rhinn (406515)

Introgression decreases allelic shuffling. by Enrique J. Schwarzkopf (6579275)

The number of gauging cross-sections where a statistically significant decreasing trend was identified. by Krzysztof Kochanek (835532)

FTY720 treatment decreased tumor growth in a xenograft model of hepatoblastoma. by Laura L. Stafman (6577184)

“…<p>(A) HuH6 cells (2.5 x 10⁶ cells in 25% Matrigel) were injected subcutaneously into the right flank of 6-week-old female athymic nude mice. …”

Rac1 depletion decreases DMV escape. by Erin A. Weddle (12133567)

Nicorandil inhibits the decrease of SYP. by Yuanzheng Zhao (10035836)

Mean and standard deviation of Race and Race Evo surface roughness in different autoclaving cycles. by Rahaf A. Almohareb (12261840)

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Reversion to susceptibility was consistent with decreasing relative <i>vanA</i> copy number. by Samuel E. Blechman (19506884)

Fx treatment abrogates the Ser/5-HT-promoted <i>Trypanosoma cruzi</i> infection of human U-87 MG astroglioma cells. by Glaucia Vilar-Pereira (686134)

Distribution of mean ∑PAHs (ng‧L⁻¹) in water samples from various watersheds: areas surrounding TP (a), areas surrounding China (b), and areas around the worl... by Xinyu Wen (3693)