Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

Performance of selected antimalarials against field isolates during the study period. by Winnie Okore (14139712)

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Association of polymorphic IC_50s versus wild<i>-</i>type at codon 876 in selected drugs tested. by Winnie Okore (14139712)

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Primers used for analysis of four SNPs in one gene. by Winnie Okore (14139712)

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Number of samples per site during the study period. by Winnie Okore (14139712)

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Performance of selected drugs against field isolates during the study period. by Winnie Okore (14139712)

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<i>In vitro</i> susceptibility responses of field isolates to antimalarials during the study period. by Winnie Okore (14139712)

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<i>Pfmrp1</i> gene SNPs data during the study period. by Winnie Okore (14139712)

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Frequency of SNPs in <i>Pfmrp1</i> gene in field isolates during the study period. by Winnie Okore (14139712)

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<i>In vitro</i> 95% CI lower and upper mean susceptibility responses of field isolates to antimalarials. by Winnie Okore (14139712)

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IC₅₀s data of antimalarials against controls. by Winnie Okore (14139712)

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Drugs IC₅₀s data during the study period. by Winnie Okore (14139712)

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SNPs IC₅₀s data at codon 876 during the study period. by Winnie Okore (14139712)

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Data Sheet 1_Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats.pdf by Evan Fuini (21224939)

Table 4_Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats.xlsx by Evan Fuini (21224939)

Data Sheet 2_Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats.docx by Evan Fuini (21224939)

Table 1_Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats.docx by Evan Fuini (21224939)

Table 5_Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats.xlsx by Evan Fuini (21224939)

Table 2_Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats.xlsx by Evan Fuini (21224939)