Gene expression of 5-HT transporter (5-HTT), 5-HT_1A receptor (5-HT_1AR) and tryptophan hydroxylase-2 (TPH2) in the raphe. by Thibault Renoir (348572)

“…<p>Measuring mRNA levels of several genes encoding proteins that regulate 5-HT homeostasis, we found significant genotype-sex interactions for both mRNA levels of (A) 5-HTT and (B) TPH2 but not for (C) 5-HT_1AR gene expression. …”

Sildenafil decreases intestinal transit time in a DSS-recovery model of IBS. by Sarah K. Sharman (3966476)

Brain 5-HT. by Caroline Sarah Biskup (163085)

“…<p>Brain 5-HT content in ng/mg tissue in (a) prefrontal cortex (b) frontal cortex and (c) hippocampus. …”

Expression of 5-HT_4(b), 5-HT_2A, 5-HT_2B and 5-HTT mRNA in left ventricular myocardium. by Trond Brattelid (290970)

“…(A) 5-HT_4(b) mRNA levels decreased with foetal and neonatal development and the level in adult myocardium was one tenth of that at day -3 but reappeared in HF; (B) 5-HT_2A mRNA expression increased at birth (day 1), decreased during neonatal development and was unaltered in HF; (C) 5-HT_2B mRNA expression was transiently increased at birth (day 1) compared to adult (day 113) and not changed in HF; (D) 5-HTT mRNA expression was lower in foetal hearts compared to neonatal, adult, Sham and HF which all showed a similar expression level. …”

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Mean Decrease in Margin (MDM) variable importance. by Yuliya V. Karpievitch (259460)

HC-070 decreases anxiety in a standard EPM. by Stefan Just (4811358)

Concentrations of 5-HT and 5-HIAA in brain tissue. by Thibault Renoir (348572)

“…Both 5-HT and 5-HIAA concentrations were decreased in the hippocampus (A/B), the cortex (C/D) and the striatum (E/F) in female HD mice when compared to WT animals. …”

Inducing proteotoxic stress in 5-HT neurons does not recapitulate a <i>Minute</i> phenotype. by Lisa Patricia Deliu (13570709)

Effect of 5-HTR blockade on the relationship between error rate and reaction time in the reward-size task. by Yukiko Hori (299784)

Subjects:

Optogenetic Recruitment of Dorsal Raphe Serotonergic Neurons Acutely Decreases Mechanosensory Responsivity in Behaving Mice by Guillaume P. Dugué (620333)

“…<i>In vivo</i>, the photoactivation of dorsal raphe serotonergic neurons gave rise to a prominent light-evoked field response that displayed some sensitivity to a 5-HT1A agonist, consistent with autoreceptor inhibition of raphe neurons. …”

Oral UOX decreased SUA (A), BUN (B) and Cr (C) (mean ± SD, n = 10). by Yu Yun (4710340)

Wnt5a expressing tumors demonstrate a decrease in markers of the basal tumor subtype. by Stephanie L. Easter (662168)

“…MMTV-Wnt1;MMTV-Wnt5a tumors demonstrated a significant decrease in K6-expressing cells as measured by T-test (* = p<0.05).…”

SinV infection causes a decrease in Neuro 2a cells number and viability. by Leandro Silva da Costa (327641)

Modifying pregnenolone to decrease its lipophilicity results in decreased cellular uptake. by Jeffrey M. McManus (7512926)

Decreasing Fires in Mediterranean Europe - Fig 5 by Marco Turco (3178641)

Claudin V is decreased following infection with Mtb. by Amanda S. Latham (12093638)

“…Exposure to Mtb H37Rv and HN878 decreased claudin V expression compared to uninfected controls in the frontal cortex (E), cerebral nuclei (J), brain stem (O), thalamus (T), and hippocampus (Y). …”

Gene expression analysis of oxidative stress-related genes in A375 melanoma cells over-expressing hMp84. by Daniele Moretti (379766)

Pharmacologically induced torpor by 5′-AMP does not decrease platelet count despite decreased body temperature. by Edwin L. de Vrij (550179)

“…<p>A) Pharmacologically induced torpor by 5′-AMP in mice does not decrease platelet count during torpor and shows an increase upon arousal. …”