Transcriptional regulation of MBII-52 and 5HT2CR by chronic cocaine in NAc. by Hongjie Chen (590575)

“…<p>Repeated cocaine administration, but not acute, significantly decreased MBII-52 (A) and not 5HT2CR (B) mRNA in NAc 24 h after the final drug injection compared with saline treatments (n = 6 mice per group; *p<0.05).…”

Discovery of β‑Arrestin Biased Ligands of 5‑HT₇R by Youngjae Kim (1463614)

“…In order to identify 5-HT₇R ligands with biased agonism, we designed and synthesized a series of tetrahydroazepine derivatives <b>1</b> and <b>2</b> with arylpyrazolo moiety or arylisoxazolo moiety. …”

Discovery of β‑Arrestin Biased Ligands of 5‑HT₇R by Youngjae Kim (1463614)

“…In order to identify 5-HT₇R ligands with biased agonism, we designed and synthesized a series of tetrahydroazepine derivatives <b>1</b> and <b>2</b> with arylpyrazolo moiety or arylisoxazolo moiety. …”

Expression of cerebral serotonin related to anxiety-like behaviors in C57BL/6 offspring induced by repeated subcutaneous prenatal exposure to low-dose lipopolysaccharide by Pei-Tan Hsueh (752475)

“…We concluded that maternal immune activation induced by exposure to a low dose of LPS decreased cerebral 5-HT levels in parallel to the down-regulation of the tph2 and slc6a4 genes and in conjunction with anxiety-like behaviors in offspring.…”

Gene expression analysis of oxidative stress-related genes in A375 melanoma cells over-expressing hMp84. by Daniele Moretti (379766)

5.HT_1A binding difference between known cause of death (KCOD) controls and SIDS. by Hannah C. Kinney (10280975)

“…When SIDS is compared to all KCOD controls, the HG, NTS, and MAO show a significant mean difference in 5-HT_1A receptor binding. …”

Daily patterns of FF in a typical harmonic syllable across seven days of baseline and three days post 5-HT lesion (after the bird began singing again). by William E. Wood (491639)

The Intracellular level of FLASH decreases during apoptosis. by Song Chen (69646)

Transient over-expression of hMp84 impairs cell proliferation and stimulates cell death in HT-144 melanoma cells. by Daniele Moretti (379766)

Image1_The serotonin receptor 5-HT2A modulates lifespan and protein feeding in Drosophila melanogaster.pdf by Allyson S. Munneke (14200148)

“…Loss of the 5-HT2A receptor extends lifespan and induces a resistance to changes in dietary protein that are normally detrimental to lifespan. 5-HT2A^−/− null mutant flies also display decreased protein feeding and protein content in the body. …”

Image2_The serotonin receptor 5-HT2A modulates lifespan and protein feeding in Drosophila melanogaster.pdf by Allyson S. Munneke (14200148)

“…Loss of the 5-HT2A receptor extends lifespan and induces a resistance to changes in dietary protein that are normally detrimental to lifespan. 5-HT2A^−/− null mutant flies also display decreased protein feeding and protein content in the body. …”

Image3_The serotonin receptor 5-HT2A modulates lifespan and protein feeding in Drosophila melanogaster.pdf by Allyson S. Munneke (14200148)

“…Loss of the 5-HT2A receptor extends lifespan and induces a resistance to changes in dietary protein that are normally detrimental to lifespan. 5-HT2A^−/− null mutant flies also display decreased protein feeding and protein content in the body. …”

Anatomical confirmation of drug injection sites. by Diana Amorim (662998)

“…<p>Schematic representation of the injection sites in the dorsomedial nucleus of the hypothalamus (DMH) (<b>A-D</b>: -3.00 mm, -3.12 mm, -3.24 mm and -3.36 mm from bregma) and medullary dorsal reticular nucleus (DRt) (<b>E-H</b>: -13.92 mm, -14.04 mm, -14.16 and -14.28 mm from bregma) of SHAM (light dots; n = 7) and ARTH (dark dots; n = 5). …”

Data_Sheet_1_Determining 5HT7R’s Involvement in Modifying the Antihyperalgesic Effects of Electroacupuncture on Rats With Recurrent Migraine.pdf by Lu Liu (171341)

“…<p>Electroacupuncture (EA) is widely used in clinical practice to relieve migraine pain. 5-HT₇ receptor (5-HT₇R) has been reported to play an excitatory role in neuronal systems and regulate hyperalgesic pain and neurogenic inflammation. 5-HT₇R could influence phosphorylation of protein kinase A (PKA)- or extracellular signal-regulated kinase₁_/₂ (ERK₁_/₂)-mediated signaling pathways, which mediate sensitization of nociceptive neurons via interacting with cyclic adenosine monophosphate (cAMP). …”

Knockdown of OAMB or 5-HT_1A in IPCs resulted in opposite phenotypes in a capillary feeding assay (CAFE). by Jiangnan Luo (218899)

“…<p><b>A</b> Diminishing 5-HT_1A in IPCs (<i>Dilp2</i>-Gal4><i>5-HT_1A</i>-RNAi) significantly decreases food intake only during day 2. …”

Table_5_Tramadol’s Inhibitory Effects on Sexual Behavior: Pharmacological Studies in Serotonin Transporter Knockout Rats.PDF by Diana C. Esquivel-Franco (5455082)

“…To investigate whether other mechanisms contribute to the inhibitory effects, WAY100,635, a 5-HT_1A receptor antagonist and naloxone, a μ-opioid receptor antagonist, were tested on sexual behavior together with tramadol. …”

Sildenafil decreases intestinal transit time in a DSS-recovery model of IBS. by Sarah K. Sharman (3966476)

hMp84 stimulates the formation of Reactive Oxygen Species (ROS) and induces oxidative alterations of phospholipids in HT-144 melanoma cells. by Daniele Moretti (379766)

Adenylate cyclase activation does not cause translocation of PKC Apl II in response to 5HT in Sf9 cells. by Carole A. Farah (336422)

“…<p><b>A)</b> Sf9 cells were cotransfected with mRFP-PKC Apl II along with either eGFP-5HT_4Apl (n = 17), eGFP-5HT_7Apl (n = 15) or eGFP-5HT_2Apl (n = 9). …”

Treatment with the antioxidant <i>N</i>-Acetyl-L-Cysteine (NAC) or with the p53 inhibitor, Pifithrin-α (PFT), prevents ROS formation in hMp84-overexpressing A375 cells. by Daniele Moretti (379766)