Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

LOH resulting in 189R/R produces a strong decrease in drug susceptibility. by Pétra Vande Zande (17628246)

Response of small airway tissues infected with EV-D94 and decreasing doses of EV-D68. by Ines Cordeiro Filipe (5849144)

“…<p>Tissues were infected with 1E7 RNA copies of EV-D94 (equivalent to 2,46E4 TCID50) and 1E7 RNA copies of EV-D68 (3,3E5 TCID50) as well as decreasing doses of the latter. …”

DataSheet1_A Non-Synonymous Point Mutation in a WD-40 Domain Repeat of EML5 Leads to Decreased Bovine Sperm Quality and Fertility.docx by Eriklis Nogueira (7475576)

Data_Sheet_1_The Risky Decrease of Fishing Reference Points Under Climate Change.docx by Morgane Travers-Trolet (548023)

“…The model was first parameterized and run to fit the historical situation (2000–2009) and then used to assess the ecosystem state for the 2050–2059 period, using two contrasting climate change scenarios (RCP 4.5 and RCP 8.5). For each condition, a monospecific MSY estimation routine was performed by varying species fishing mortality independently and allowed estimation of reference points for each species. …”

Naringenin decreases total cell viability. by Lauren A. Eanes (20995499)

Fold change of TIL subsets in paired TNBCs (N = 12 pts including 10 prim-met, and 2 met-met specimens) using log2 ratio of metastatic versus primary TNBC (n = 10, ●) or second recu... by Ting-Fang He (5210948)

RhoA gene expression and activity are impacted with increased intracellular 5HT. by Celeste M. Sheftel (9557588)

“…<p><b>A.</b><i>RhoA</i> mRNA expression is significantly upregulated with FLX and 5HTP compared to controls and is significantly decreased in FLX + MDC. …”

Design, Synthesis, and Biological Evaluation of New Peripheral 5HT_2A Antagonists for Nonalcoholic Fatty Liver Disease by Minhee Kim (1592440)

“…Here, structural modifications of pimavanserin (CNS drug), a 5HT_2A antagonist approved for Parkinson’s disease, led us to synthesize new peripherally acting 5HT_2A antagonists. …”

Data Sheet 1_Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats.pdf by Evan Fuini (21224939)

Table 4_Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats.xlsx by Evan Fuini (21224939)

Data Sheet 2_Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats.docx by Evan Fuini (21224939)

Table 1_Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats.docx by Evan Fuini (21224939)

Table 5_Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats.xlsx by Evan Fuini (21224939)

Table 2_Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats.xlsx by Evan Fuini (21224939)

Table 3_Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats.xlsx by Evan Fuini (21224939)

S5 Fig - by Meihui Chen (1670020)

28 days of testosterone depletion decreases fiber CSA only in the TA muscle and only at 1.5-month-old mice. by Arik Davidyan (10450896)

Homozygous deletion of <i>ERG251</i> leads to the decreased ergosterol accumulation in the absence of FLC and decreased production of toxic dienol in the presence of FLC. by Xin Zhou (54275)