Molecular interactions of agonist and inverse agonist ligands at serotonin 5-HT_2C G protein-coupled receptors: computational ligand docking and molecular dynamics studie... by Tania C. Córdova-Sintjago (597380)

“…<div><p>To understand molecular determinants for ligand activation of the serotonin 5-HT_2C G protein-coupled receptor (GPCR), a drug target for obesity and neuropsychiatric disorders, a 5-HT_2C homology model was built according to an adrenergic β₂ GPCR (β₂AR) structure and validated using a 5-HT_2B GPCR crystal structure. …”

ASO treatment suppresses the palbociclib-mediated induction of MEG3 and decrease in cell proliferation in SK-MES-1 cells. by Traci L. Kruer (3342425)

Conditional Trhn OE in adult glia induces EB experience-dependent 5-HT up-regulation and pruning. by Vanessa Kay Miller (19775496)

“…VM7 colabeling for serotonin (5-HT, green) and Or42a innervation (Or42a::GFP, red) following mature adult exposure for 24 hours to either odorant vehicle (oil, left) or 25% odorant (EB, right). …”

TIMP3 overexpression decreases tibial bone mechanical properties from macroscale to nanoscale mechanics. by Blandine Poulet (2939877)

“…<p>A, Von Kossa staining of tibia epiphysis and metaphysis of WT and TIMP3 Tg/Tg mice showed decreased trabecular bone in TIMP3 Tg/Tg mice (Magnification x2). …”

Increased ROS level decreases RLS in respiratory-deficient cells. by Dae-Gwan Yi (5410298)

HO-1 overexpression decreases Nox4 activity in C-20/A4 chondrocytes. by Francis Rousset (424375)

Decreased GH storage and secretion in PICK1-deficient mice. by Birgitte Holst (250548)

“…<p>(A) The livers of PICK-1-deficient mice had a significantly lower weight than those of WT mice (**<i>p</i><0.01). …”

hMSC implantation decreased striatal atrophy in HD mice. by Brooke R. Snyder (253093)

Immobility time of NrbKO and SpKO mice in the forced swim test (FST) at 3–5 months of age (young adult). by Huiying Wu (1587136)

mTOR activity is decreased in KSR1-deficient T cells. by Marie Le Borgne (337225)

Loss of Cntnap2 decreases specifically stabilization of new spines. by Amos Gdalyahu (3213810)

“…<p><b>a.</b> From left to right: Chronic imaging through a cranial window of L5 pyramidal neuron. …”

Decreased area of remodeling during tendon healing in Mmp9 by Alayna E. Loiselle (151690)

Reduced I_A decreases the stimulus threshold for short-term synaptic plasticity. by Ángela Fontán-Lozano (193161)

Decreased proliferation, but not apoptosis, is responsible for reduction of growth plate height. by Marco Cardelli (494637)

Overexpression of Pax6 decreases Olig2 protein levels. by Eun Sook Jang (217069)

“…(<b>a</b>) Oli-Neu cells were transfected with flag-tagged WT Pax6 (WT), Pax6(5a)R128C (128), or eGFP control vector (-). …”

Decreased natTregs observed in the lungs in the absence of TLR2. by Amanda McBride (421742)

IL-18 induces death in HT-29 cells. by Ossama Allam (5043434)

mTOR inhibition with rapamycin decreases MEC survival and branching. by Meghan M. Morrison (683792)

NEMO knockout murine dermal fibroblasts show a decreased nuclear translocation of p65. by Patrick Meyer (3395285)

Normal TLR4 and MD2 expression and decreased IL10 secretion and A20 expression by <i>cpdm</i> BMDC. by Zhe Wang (41178)