Systemic role of the peripheral 5HT. by Igor Erjavec (2265613)

“…Elevated 5HT bidirectionally influences the plasma insulin level (green-red arrow) and induces the hyperthrophy of pancreatic β-cells (dashed arrow), leading to type 2 diabetes with an increased plasma glucose, insulin resistance, glucose intolerance, visceral fat volume and decreased muscle strength. …”

Occupancy estimation. by Yukiko Hori (299784)

Subjects:

Prenatal treatment decreases proliferation and increases apoptosis in small intestine. by Fátima Ramalhosa (3095712)

“…(B) Proliferation rate is decreased within the crypts in <i>iuGC</i> rats, n = 3, 4, 5 CTR and n = 3, 6, 3 <i>iuGC</i>. …”

<i>Gng5^−/−</i> mutants have decreased cell proliferation and survival. by Anne M. Moon (134982)

Genotype frequencies of the polymorphisms <i>rs1799971</i> (OPRM1), <i>rs6296</i> (5-HT_1A) and the triallelic 5-HTT for the whole group, as well as fibromyalgia (FM) pat... by Jeanette Tour (10790855)

Respiratory network responses to systemic 5-HT_2AR and 5-HT_2BR activation. by Marcus Niebert (183419)

“…Statistical analysis (paired t-test) is denoted in the panels on the right side. (<b>A</b>–<b>C</b>) Action of 5-HT_2AR and 5-HT_2BR ligands in the perfused brainstem preparation. …”

Effect of 2%, 4%, and 6% HQ cream on hippocampal 5-HT level and 5-HT_{1A /1B} receptor expression. by Huali Wu (349567)

“…<p>(A) HQ decreases hippocampus 5-HT level in a dose-dependent manner. …”

Additional Analysis of visually induced calcium transients in Fig 5. by Maureen M. Sampson (9322886)

“…<p>Visually induced calcium transients were recorded in flies expressing L2-split-GAL4>GCaMP6f as in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1009003#pgen.1009003.g005" target="_blank">Fig 5</a>. …”

Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

GXM decreases the trans-endothelial electrical resistance (TEER) and transmigration of <i>C</i>. <i>neoformans</i> through HBECs in a blood brain barrier (BBB) model. by Hiu Ham Lee (15374677)

Normalized pressure pain thresholds (PPTs) (mean ± SEM) at start, middle, end and 5 minutes after a standardized tourniquet test. by Jeanette Tour (10790855)

Matrix crosslinking decreases cell migration persistence. by Michael Pamonag (12295175)

<i>iuGC</i> animals at 3 and 8 months old have a decreased GI transit. by Fátima Ramalhosa (3095712)

Comparison of the effects of several 5-HT receptor antagonists on the plasma concentrations of metabolites and insulin, following 5-HT injection in sheep and mice. by Hitoshi Watanabe (519631)

“…</p>b<p>5-HT: serotonin; Me: methysergide; Ke: ketanserin; SB-26: SB-269970; SB-20: SB-204070; Ro: Ro 04-6790; I: increase; D: decrease; N: no change; +: effective in blocking the effect of 5-HT; −: ineffective in blocking the effect of 5-HT.…”

CK1δ-specific kinase activity in HT1080 cells is decreased after activation of Chk1. by Joachim Bischof (189845)

KRAP−/− Mice Showed Decreased Weight-Gain and Decreased Adiposity. by Takahiro Fujimoto (268158)

Schematic representation of possible intracellular 5-HT signaling pathways in chondrocytes. by Ayaka Hori (4597795)

“…Then, the phosphorylated ERK1/2 level is increased through both activation of PKCε and PKCζ; as a result, CCN2 production is decreased. Furthermore, independent of PKC, 5-HT may transmit a certain unknown signal to JNK, which also inhibits the CCN2 production in chondrocytes.…”

Additional Analysis of visually induced calcium transients in Fig 6. by Maureen M. Sampson (9322886)

“…<p>Visually induced calcium transients were recorded in 5-HT2B +/- or 5-HT2B -/- flies as described in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1009003#pgen.1009003.g006" target="_blank">Fig 6</a>. …”

Serotonin modulates L2 neuron visually induced calcium transient kinetics. by Maureen M. Sampson (9322886)

“…Light or dark stimuli (A, middle panel, white and black vertical bars respectively) were flashed at random every 5 s for 6 min. …”