Sildenafil decreases intestinal transit time in a DSS-recovery model of IBS. by Sarah K. Sharman (3966476)

Brain 5-HT. by Caroline Sarah Biskup (163085)

“…<p>Brain 5-HT content in ng/mg tissue in (a) prefrontal cortex (b) frontal cortex and (c) hippocampus. …”

HRMECs treated with SUZ12 siRNA demonstrate increased miR-200b expression, decreased VEGF expression and decreased endothelial branching. by Michael Anthony Ruiz (726055)

“…However, transfection of SUZ12 siRNA significantly reduced endothelial branching compared to HG+control siRNA. [NG+control siRNA = 5mM D-glucose + 100nM control siRNA, HG+control siRNA = 25mM D-glucose + 100nM control siRNA, HG+EZH2 siRNA = 25mM D-glucose + 100nM EZH2 siRNA, HG+SUZ12 siRNA = 25mM + 100nM SUZ12 siRNA; identical letters represent groups that are not significantly different; p < 0.05; n = 6; data expressed as mean ± SEM, normalized to U6 or β-actin and expressed as a fold change of NG+control siRNA].…”

Aspirin decreases expressions of Sp1, Sp3, Sp4 and Sp-regulated gene products in colon cancer cells. by Satya Pathi (301408)

“…Results are typical of duplicate experiments. (E) Aspirin decreases reporter gene activity. Cells were transfected with pSp1For4, pSp3For5, pVEGF and pSurvivin and treated with DMSO or aspirin (5 or 10 mM). …”

PB + PER exposure decreased SYP staining in the hippocampi and cerebral cortices of exposed mice. by Zuchra Zakirova (431614)

Production of intracellular reactive oxygen species (ROS) in hESCs was decreased after NaF treatment. by Xin Fu (448766)

“…<p>(A) Assessment of ROS levels by 2,7-dichlorodihydrofluorescein-diacetate (DCFH-DA) staining revealed that the percentage of fluorescent dichlorofluorescein (DCF)-positive hESCs was significantly decreased in the 2 and 4 mM NaF-treated groups, and the mean fluorescence intensities of hESCs were significantly lower in the 1, 2 and 4 mM NaF-treated groups. …”

Mutation of Ser-473 in GC-A to alanine but not glutamate decreases ANP-stimulated guanylyl cyclase activity. by Andrea R. Yoder (165684)

Expression of 5-HT_4(b), 5-HT_2A, 5-HT_2B and 5-HTT mRNA in left ventricular myocardium. by Trond Brattelid (290970)

“…(A) 5-HT_4(b) mRNA levels decreased with foetal and neonatal development and the level in adult myocardium was one tenth of that at day -3 but reappeared in HF; (B) 5-HT_2A mRNA expression increased at birth (day 1), decreased during neonatal development and was unaltered in HF; (C) 5-HT_2B mRNA expression was transiently increased at birth (day 1) compared to adult (day 113) and not changed in HF; (D) 5-HTT mRNA expression was lower in foetal hearts compared to neonatal, adult, Sham and HF which all showed a similar expression level. …”

Non-hydrolysable ATP analogues prevent decrease of I_Ca,L by metabolic inhibition. by Giedrius Kanaporis (4405525)

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

The effects of NAC on the decreased number of myotube formations caused by arecoline. by Yi-Xuan Li (6633845)

DHA decreased cell viability in HepG3 cells. by Arlet Hernandez (12289155)

AICAR-activated AMPK decreased SREBP-2 protein levels. by Shudong Liu (733425)

The utility of Hmp for NO• consumption and tolerance decreases with increased NO• delivery rate. by Jonathan L. Robinson (409406)

Berberine decreases IBMX- and FSK-induced CRE luciferase activity. by Juan Zhang (48597)

Decreasing bioavailable copper in vivo modulates tumor vessel dimensions. by Andrew Crowe (450839)

Processive receptor methylation compromises adaptation and decreases signaling noise. by William Pontius (460803)

“…(C) Increasing processivity also decreases the magnitude of fluctuations in <i>a</i>(<i>t</i>) in the adapted state around the mean value <i>a</i>₀. …”

Stable knockdown of JTB in HCC cells decreases cell apoptosis. by Yun-Peng Liu (108506)

Mean Decrease in Margin (MDM) variable importance. by Yuliya V. Karpievitch (259460)