Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

NgR1 KO mice exhibited an increase in excitatory synapses and a decrease in inhibitory synapses, indicating an imbalance of synaptic transmission. by Jinwei Zhang (462455)

“…The inhibitory synaptic density of NgR1 mice showed a significant decrease when compared to WT mice (***P <  0.001). …”

GXM decreases the trans-endothelial electrical resistance (TEER) and transmigration of <i>C</i>. <i>neoformans</i> through HBECs in a blood brain barrier (BBB) model. by Hiu Ham Lee (15374677)

Normalized pressure pain thresholds (PPTs) (mean ± SEM) at start, middle, end and 5 minutes after a standardized tourniquet test. by Jeanette Tour (10790855)

NG2 knockdown in GBM xenografts increased vascular reabsorption, decreased plasma volume and normalized tumour vasculature. by Jian Wang (5901)

Matrix crosslinking decreases cell migration persistence. by Michael Pamonag (12295175)

<i>iuGC</i> animals at 3 and 8 months old have a decreased GI transit. by Fátima Ramalhosa (3095712)

Decrease in circulating iNKT cell activation during regadenoson (RA) infusion into patients with COVID-19. by Joseph Rabin (7399436)

Subjects:

Comparison of the effects of several 5-HT receptor antagonists on the plasma concentrations of metabolites and insulin, following 5-HT injection in sheep and mice. by Hitoshi Watanabe (519631)

“…</p>b<p>5-HT: serotonin; Me: methysergide; Ke: ketanserin; SB-26: SB-269970; SB-20: SB-204070; Ro: Ro 04-6790; I: increase; D: decrease; N: no change; +: effective in blocking the effect of 5-HT; −: ineffective in blocking the effect of 5-HT.…”

CK1δ-specific kinase activity in HT1080 cells is decreased after activation of Chk1. by Joachim Bischof (189845)

KRAP−/− Mice Showed Decreased Weight-Gain and Decreased Adiposity. by Takahiro Fujimoto (268158)

Decreased proliferation in <i>AnxA2</i>kd and <i>AnxA5</i>kd cells. by Damian C. Genetos (325684)

Schematic representation of possible intracellular 5-HT signaling pathways in chondrocytes. by Ayaka Hori (4597795)

“…Then, the phosphorylated ERK1/2 level is increased through both activation of PKCε and PKCζ; as a result, CCN2 production is decreased. Furthermore, independent of PKC, 5-HT may transmit a certain unknown signal to JNK, which also inhibits the CCN2 production in chondrocytes.…”

Additional Analysis of visually induced calcium transients in Fig 6. by Maureen M. Sampson (9322886)

“…<p>Visually induced calcium transients were recorded in 5-HT2B +/- or 5-HT2B -/- flies as described in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1009003#pgen.1009003.g006" target="_blank">Fig 6</a>. …”

Serotonin modulates L2 neuron visually induced calcium transient kinetics. by Maureen M. Sampson (9322886)

“…Light or dark stimuli (A, middle panel, white and black vertical bars respectively) were flashed at random every 5 s for 6 min. …”

TGF-β-mediated EMT decreases Dlg5 expression. by Takuhito Sezaki (169150)

“…<p><b>A:</b> LLc-PK1 cells were incubated with 4 ng/ml of TGF-β for three days. …”

c-Yes knock-down increases apoptosis and decreases growth in soft-agar and in mouse xenografts. by Florence Sancier (229473)

Gal-3 is upregulated in hypoxia in NG97ht cells. by Rafael Yamashita Ikemori (698128)

“…Five main forms (1 to 5) were detected in the NG97ht cell line with their isoelectric point (IP) ranging from 8.00 to 9.33 and molecular sizes from 27.5 and 29.7 kDa. …”

Ethanol intoxication combined with burn injury decreases miRNA155 expression in T cells. by Xiaoling Li (129705)

IFNγ enhances the Ser/5-HT-promoted <i>Trypanosoma cruzi</i> uptake by the human U-87 MG astroglioma cells. by Glaucia Vilar-Pereira (686134)