Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease by Xiaojuan Han (3278601)

“…</p> <p><b>Abbreviations:</b> 3-MA: 3-methyladenine; AAV: adeno-associated virus; ACTB: actin, beta; AIF1/IBA1: allograft inflammatory factor 1; ATG5: autophagy related 5; ATG7: autophagy related 7; BafA1: bafilomycin A_1; BECN1: beclin 1, autophagy related; CASP1: caspase 1; CNS: central nervous system; CQ: chloroquine; DA neurons: dopaminergic neurons; DAMPS: damage-associated molecular patterns; DAPI: 4’,6-diamidino-2-phenylindole; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; GFAP: glial fibrillary acidic protein; IP: immunoprecipitation; i.p.: intraperitoneally; Ka: kaempferol; KD: knockdown; KO: knockout; LPS: lipopolysaccharide; IL1B: interleukin 1 beta; IL6: interleukin 6; Ly: lysate; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MPTP: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NC: negative control; NDD: neurodegenerative diseases; NLRP3: NLR family, pyrin domain containing 3; OE: overexpression; PD: Parkinson disease; poly-Ub: poly-ubiquitin; PTM: post-translational modification; PYCARD/ASC: PYD and CARD domain containing; Rapa: rapamycin; RFP: red fluorescent protein; SN: supernatant; SNCA: synuclein alpha; SNpc: substantia nigra pars compacta; SQSTM1: sequestosome 1; TH: tyrosine hydroxylase; TNF/TNF-alpha: tumor necrosis factor; Ub: ubiquitin; WT: wild type</p>…”

cGKII phosphorylates FoxO1 <i>in vitro</i>. by Tomoko Kanao (180395)

“…The phosphorylation by cGKII or LRRK2 was decreased in the P3 S319A mutant. (<b>G</b>) Co-incubation of cGKII and LRRK2 enhanced GST-FoxO-C phosphorylation. …”

Image_8_Maternal prebiotic supplementation impacts colitis development in offspring mice.tif by Amélie Lê (14331069)

“…In addition, maternal prebiotic supplementation induced an overabundance of eight bacterial families and a decrease in the butyrate caecal concentration in DSS-treated offspring.…”

Physiological effects of drug administration. by Mani Erfanian Abdoust (14295610)

“…<p>Plots depict the change in each physiological parameter following drug administration. (<b>a</b>) Diastolic BP decreased at T1 (HDI_Mean = −3.75, HDI_95% = [−5.71; −1.85]) and T2 (HDI_Mean = −2.99, HDI_95% = [−4.96; −1.07]) compared to T0. …”

DataSheet_1_4-nitroquinoline 1-oxide induces immune cells death to onset early immunosuppression during oral squamous cell carcinoma development.pdf by Satya Ranjan Sahu (17267911)

“…Additionally, γδ T and CD5⁺ B lymphocyte populations decreased at both pre- and post-cancerous stages of OSCC. …”

Table1_Comprehensive transcriptome analysis of AP2/ERFs in Osmanthus fragrans reveals the role of OfERF017-mediated organic acid metabolism pathway in flower senescence.xlsx by Jing-Jing Zou (19743220)

“…<p>Osmanthus fragrans is an ethylene-sensitive flower, and flower senescence was mediated by ethylene-responsive transcription factors (OfERFs). A total of 227 OfERFs were identified from O. fragrans, which were classified into five subfamilies: AP2 (35), DREB (57), ERF (125), RAV (6), and Soloist (4). …”

Datasheet1_Age-related reference intervals for ambulatory electrocardiographic parameters in healthy individuals.docx by Kenichi Hashimoto (12904415)

“…</p>Conclusions<p>Age-specific reference intervals of VE and SVE in a large population of healthy participants over a wide age range were generated. …”

Patient Age and the Prognosis of Idiopathic Membranous Nephropathy by Makoto Yamaguchi (588823)

“…A <25% decrease in proteinuria at 1 month after immunosuppressive therapy initiation also predicted infection (adjusted HR = 6.72, 95% CI: 1.51–37.8; <i>P</i> = 0.012).…”

Supplementary Material for: Long -term multimodal exercise intervention for patients with frontotemporal lobar degeneration: Feasibility and preliminary outcomes by Nemoto M. (20397440)

“…While there were improvements in some domains, such as recovery self-efficacy and exercise efficacy, the MMSE-J scores showed an overall slight decline, especially in the SD case where a marked decrease was observed. Additionally, three physical function items showed no effect, except for a positive outcome in the TUG test. …”

Skeletal muscle abnormalities in <i>ddx27</i> mutant zebrafish. by Alexis H. Bennett (4922524)

“…<p>(A) Microscopic visualization of control and mutant larval zebrafish (<i>osoi</i>) at 5 days post fertilization (dpf). …”

Effects of message content condition on outcomes. by Rhyan N. Vereen (10765678)

“…Participants were randomly assigned to view a CI, general audience, or control campaign. Outcomes were intentions to decrease sugary drink consumption (primary outcome; range 1–7), knowledge of (range 0–4) and perceived susceptibility to health harms (range 1–5) and sharing intentions (range 0–3).…”

Migrants, healthy worker effect, and mortality trends in the Gulf Cooperation Council countries by Karima Chaabna (785895)

“…This association was statistically significant among the 5–14 and 15–49 age groups, which have the largest population size. …”

Table_1_Case report: Management and long-term ophthalmic sequelae of monogenean ocular infestation in cownose rays (Rhinoptera bonasus).XLSX by April Beatty (18849793)

“…The entire population underwent frequent therapeutic water changes with a scheduled decrease in salinity, increase in temperature, and a series of seven praziquantel tank treatments. …”

Image1.PDF by Nara Szostaczuk (4988210)

“…</p><p>Methods: Three groups of male rats were studied at a juvenile age (25 days old) and during adulthood (3 and 6 months old): the offspring of ad libitum fed dams (controls), the offspring of dams that were diet restricted (20%) from days 1 to 12 of gestation (CR), and CR rats supplemented with a daily oral dose of leptin (equivalent to 5 times the average amount they could receive each day from maternal milk) throughout lactation (CR-Leptin). …”

Image 2_Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 ameliorate barrier dysfunction in human induced pluripotent stem cell-derived crypt-vil... by Kyosuke Kobayashi (21526655)

“…Regarding cell differentiation, LAB suppressed the downregulation of LGR5, VIL1, LYZ and MUC2 by cytokines. Moreover, they ameliorated reduced mucin 2 protein production and decreased the number of mucin 2-positive cells. …”

Variation in Honey Bee Gut Microbial Diversity Affected by Ontogenetic Stage, Age and Geographic Location by Zuzana Hroncova (701561)

“…The results showed that the microbial tract of 6-day-old 5th instar larvae were nearly equally rich in total microbial counts per total digestive tract weight as foraging bees, showing a high percentage of various lactobacilli (Firmicutes) and <i>Gilliamella apicola</i> (Gammaproteobacteria 1). …”

Surfactant-Induced Ordering and Wetting Transitions of Droplets of Thermotropic Liquid Crystals “Caged” Inside Partially Filled Polymeric Capsules by Rebecca J. Carlton (1346949)

“…Specifically, upon addition of SDS to the aqueous phase, we observed the contact angles (θ) of caged LC on the interior surface of the capsule to decrease, resulting in a progression of complex droplet shapes, including lenses (θ ≈ 130 ± 10°), hemispheres (θ ≈ 89 ± 5°), and concave hemispheres (θ < 85°). …”

Multiplexed Detection of Epigenetic Markers Using Quantum Dot (QD)-Encoded Hydrogel Microparticles by Sang Yun Yeom (2573368)

Image_1_High Betaine and Dynamic Increase of Betaine Levels Are Both Associated With Poor Prognosis of Patients With Pulmonary Hypertension.pdf by Yicheng Yang (12319574)

“…</p>Results<p>Finally, a total of 216 patients with PH were included and the medians for betaine plasma levels in the total patients group, low betaine, and high betaine groups were 49.8 (39.0, 68.3) μM, 39.0 (33.5, 44.7) μM, and 68.1 (57.8, 88.7) μM, respectively. …”

Image_2_Galantamine ameliorates hyperoxia-induced brain injury in neonatal mice.TIF by Nahla Zaghloul (636747)

“…Treated hyperoxic group showed a significant increase of choline acetyl transferase (ChAT) expression and a decrease of acetyl choline esterase activity, thus increasing acetyl choline levels in hyperoxia environment. …”