Inhibiting translation in 5-HT neurons does not recapitulate a <i>Minute</i> phenotype. by Lisa Patricia Deliu (13570709)

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Rapid degeneration of 5-HT neurons in SERT-Cre^cre/wt Munc18-1^lox/lox mice. by Jacobus J. Dudok (338648)

“…(O) Analysis of the number of 5-HT cell bodies in the sections showed that there is no difference at E16, but at E18 and P2 there is a decrease of 80% to 90% in the number of 5-HT cell bodies in SERT-Cre^cre/wt Munc18-1^lox/lox sections. …”

Quercetin decreases proliferation (A) and induces apoptosis (B) in cultured PASMC from control rats. by Daniel Morales-Cano (668199)

The sialidase inhibitor Neu5Ac2en decreases growth of wt <i>C. canimorsus 5</i> in presence of macrophages. by Manuela Mally (348810)

Subjects:

Concentrations of 5-HT and 5-HIAA in brain tissue. by Thibault Renoir (348572)

“…Both 5-HT and 5-HIAA concentrations were decreased in the hippocampus (A/B), the cortex (C/D) and the striatum (E/F) in female HD mice when compared to WT animals. …”

Decreased FOXP3 Treg induction in LAG-3 KO cells <i>in vitro</i>. by Nicholas M. Durham (174371)

Inducing proteotoxic stress in 5-HT neurons does not recapitulate a <i>Minute</i> phenotype. by Lisa Patricia Deliu (13570709)

The M650K mutation decreases the firing rate of DRG neurons. by Andreas M. Kist (3106548)

Decreasing RhoB expression by siRNA transfection does not change Ad5wt attachment or internalization. by Dragomira Majhen (462312)

5-HT- induced mitochondrial ROS inhibits <i>P</i>. <i>berghei</i> infection. by Li Gao (131516)

Effect of 5-HTR blockade on the relationship between error rate and reaction time in the reward-size task. by Yukiko Hori (299784)

Subjects:

WT1 mRNA and protein levels are decreased by GnRH. by Debalina Bagchi (686046)

Optogenetic Recruitment of Dorsal Raphe Serotonergic Neurons Acutely Decreases Mechanosensory Responsivity in Behaving Mice by Guillaume P. Dugué (620333)

“…<i>In vivo</i>, the photoactivation of dorsal raphe serotonergic neurons gave rise to a prominent light-evoked field response that displayed some sensitivity to a 5-HT1A agonist, consistent with autoreceptor inhibition of raphe neurons. …”

(A and B) Relative increases (/wt, when wt) or decreases (wt/, when wt) of gene expression were plotted versus their distance to the closest telomere (A) or centromere (B) by Stefanie E. Grund (54022)

(A) MKP-1 siRNA decreases MKP-1 expression in RAW cell lines by Wangsen Cao (49354)

Decreased neuronal cells with increased astrocytes in HIV-1 Tg rats. by Young-Eun Cho (325567)

Decreased FOXP3 Treg induction in LAG-3 KO T-cells in an <i>in vivo</i> self-tolerance. by Nicholas M. Durham (174371)

Systemic role of the peripheral 5HT. by Igor Erjavec (2265613)

“…Elevated 5HT bidirectionally influences the plasma insulin level (green-red arrow) and induces the hyperthrophy of pancreatic β-cells (dashed arrow), leading to type 2 diabetes with an increased plasma glucose, insulin resistance, glucose intolerance, visceral fat volume and decreased muscle strength. …”