Treatment with proteasome inhibitor bortezomib decreases organic anion transporting polypeptide (OATP) 1B3-mediated transport in a substrate-dependent manner by Khondoker Alam (1443499)

“…Pretreatment with bortezomib (50–250 nM, 2–7 h) significantly decreased transport of [³H]CCK-8, a specific OATP1B3 substrate, in HEK293-OATP1B3 and human sandwich-cultured hepatocytes (SCH). …”

Effect of melatonin (50 μM) on the TGF-β1 (10 ng/mL, 72 h)-mediated TGF-β1/Smad pathway and EMT in HBdSMCs. by Yang Zhang (30734)

Affinity analysis results (with a confidence level above 50%). by Marta R. Jabłońska (8491404)

<i>USP28</i> protein level was decreased by hypoxia signaling via both protein degradation and transcriptional repression in A549 cells. by Qin Li (36669)

“…(C) Hypoxia decreased <i>USP28</i> mRNA levels in A549 cells. A549 cells were cultured in 1% O₂ for 24 hr. …”

Schematic representation of possible intracellular 5-HT signaling pathways in chondrocytes. by Ayaka Hori (4597795)

“…Then, the phosphorylated ERK1/2 level is increased through both activation of PKCε and PKCζ; as a result, CCN2 production is decreased. Furthermore, independent of PKC, 5-HT may transmit a certain unknown signal to JNK, which also inhibits the CCN2 production in chondrocytes.…”

Effect of 2% HQ, 0.05% INN and 0.1% TAC on hippocampal 5-HT level and 5-HT_{1A /1B} receptor expression. by Huali Wu (349567)

“…Scale bar = 50μm. (C) IOD values of the expression of 5-HT_1A receptor in CA1 region. …”

Synthesis and Biological Evaluation of Peripheral 5HT_2B Antagonists for Liver Fibrosis by Jihyeon Yoon (8705706)

“…Recent studies have shown that antagonizing 5-hydroxytryptamine receptor 2B (5HT_2B) stimulates the apoptosis of activated hepatic stellate cells and inhibits their proliferation while concurrently regressing hepatocyte proliferation. …”

Synthesis and Biological Evaluation of Peripheral 5HT_2B Antagonists for Liver Fibrosis by Jihyeon Yoon (8705706)

“…Recent studies have shown that antagonizing 5-hydroxytryptamine receptor 2B (5HT_2B) stimulates the apoptosis of activated hepatic stellate cells and inhibits their proliferation while concurrently regressing hepatocyte proliferation. …”

Heterogeneous distribution of 5-HTR subtypes as measured by PET. by Yukiko Hori (299784)

Subjects:

Effect of 5-HTR blockade on cost-based motivation. by Yukiko Hori (299784)

Subjects:

Geniposide(Gen) significantly decreased the levels of TNF-α and MIP-1α in BALF of bleomycin-induced PF mice. by Jian-Bin Yin (19556105)

Cardiac sympathetic fiber density decreased post-6-OHDA and correlated with <i>in vivo</i> and post mortem markers. by Jeanette M. Metzger (8259900)

PRV and HSV-1 employ US3 to decrease Bclaf1 in a proteasome-dependent manner. by Chao Qin (119135)

The distributions of the end-simulation adolescence-limited proportion when (a) <i>k</i> is increased or decreased by 50%, (b) <i>c</i> is increased or decreased by 50%, (c) <i>γ</i> is increased or decreased by 50%, and (d) Δ<i>e</i> is increased or decreased by 50%, compared against the benchmark distribution <i>F</i>(<b>p</b>₀) for the parameters shown in Table 1. by Jia Ning Leaw (752775)

Effects of gravity changes on gene expression of BDNF and serotonin receptors in the mouse brain by Chihiro Ishikawa (4093267)

“…BDNF expression was decreased in the ventral hippocampus and hypothalamus, whereas increased in the cerebellum. 5-HT1BR expression was decreased in the cerebellum, whereas increased in the ventral hippocampus and caudate putamen. …”

SRC-3 treatment decreased tumor growth in a Jeko-1 ibrutinib resistant mouse model. by Imani Bijou (18275174)

Gal-3 is upregulated in hypoxia in NG97ht cells. by Rafael Yamashita Ikemori (698128)

“…Five main forms (1 to 5) were detected in the NG97ht cell line with their isoelectric point (IP) ranging from 8.00 to 9.33 and molecular sizes from 27.5 and 29.7 kDa. …”

Oral UOX decreased SUA (A), BUN (B) and Cr (C) (mean ± SD, n = 10). by Yu Yun (4710340)

No discernible effect of high-dose 5-HT_2AR blockade on error rates in the reward-size task. by Yukiko Hori (299784)

Subjects:

Decrease in extracellular Zn²⁺ in the hippocampus by zinc chelators. by Atsushi Takeda (18203)