Development of Prolinol Containing Inhibitors of Hypoxanthine–Guanine–Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design by Dianne T. Keough (4660351)

“…Against <i>TBr</i> in cell culture, a prodrug exhibited an EC₅₀ of 10 μM. …”

The KOR antagonist BTRX-335140 blocks U-69,593 responses in mPFC-projecting VTA dopamine neurons. by Elyssa B. Margolis (7933838)

3‑Hydroxypyridin-4(1<i>H</i>)‑one Derivatives as <i>pqs</i> Quorum Sensing Inhibitors Attenuate Virulence and Reduce Antibiotic Resistance in <i>Pseudomonas aeruginosa</i> by Zhi-Ying Miao (9388615)

“…The most potent derivative <b>16e</b> was identified as a selective inhibitor of the <i>pqs</i> system (IC₅₀ = 3.7 μM) and its related virulence factor pyocyanin (IC₅₀ = 2.7 μM). …”

Image_3_Hyperglycemia Promotes Chemoresistance Through the Reduction of the Mitochondrial DNA Damage, the Bax/Bcl-2 and Bax/Bcl-XL Ratio, and the Cells in Sub-G1 Phase Due to Antit... by Loredana Bergandi (4170769)

“…Finally, hyperglycemia reduced cell death by decreasing the cell percentage in sub-G1 peak induced by DOX (via a cell cycle arrest in the G2/M phase) and 5-FU (via a cell cycle arrest in the S phase) in HT29 and LOVO cells. …”

Image_1_Hyperglycemia Promotes Chemoresistance Through the Reduction of the Mitochondrial DNA Damage, the Bax/Bcl-2 and Bax/Bcl-XL Ratio, and the Cells in Sub-G1 Phase Due to Antit... by Loredana Bergandi (4170769)

“…Finally, hyperglycemia reduced cell death by decreasing the cell percentage in sub-G1 peak induced by DOX (via a cell cycle arrest in the G2/M phase) and 5-FU (via a cell cycle arrest in the S phase) in HT29 and LOVO cells. …”

Image_4_Hyperglycemia Promotes Chemoresistance Through the Reduction of the Mitochondrial DNA Damage, the Bax/Bcl-2 and Bax/Bcl-XL Ratio, and the Cells in Sub-G1 Phase Due to Antit... by Loredana Bergandi (4170769)

“…Finally, hyperglycemia reduced cell death by decreasing the cell percentage in sub-G1 peak induced by DOX (via a cell cycle arrest in the G2/M phase) and 5-FU (via a cell cycle arrest in the S phase) in HT29 and LOVO cells. …”

Image_2_Hyperglycemia Promotes Chemoresistance Through the Reduction of the Mitochondrial DNA Damage, the Bax/Bcl-2 and Bax/Bcl-XL Ratio, and the Cells in Sub-G1 Phase Due to Antit... by Loredana Bergandi (4170769)

“…Finally, hyperglycemia reduced cell death by decreasing the cell percentage in sub-G1 peak induced by DOX (via a cell cycle arrest in the G2/M phase) and 5-FU (via a cell cycle arrest in the S phase) in HT29 and LOVO cells. …”

Data_Sheet_1_Hyperglycemia Promotes Chemoresistance Through the Reduction of the Mitochondrial DNA Damage, the Bax/Bcl-2 and Bax/Bcl-XL Ratio, and the Cells in Sub-G1 Phase Due to... by Loredana Bergandi (4170769)

“…Finally, hyperglycemia reduced cell death by decreasing the cell percentage in sub-G1 peak induced by DOX (via a cell cycle arrest in the G2/M phase) and 5-FU (via a cell cycle arrest in the S phase) in HT29 and LOVO cells. …”

Curcumin restores D-gal-induced SCs TJ damage <i>in vitro.</i> by Chen Xue (699418)

D-gal-induced aging led to tight junction damage in SCs <i>in vitro.</i> by Chen Xue (699418)

Curcumin restores aging-induced disruption of the BTB in mice by activating autophagy in mouse testes injected with D-gal. by Chen Xue (699418)

The synthetic lethality of the <i>erd1</i>Δ mutation with the Neo1p-depleted <i>cfs1</i>Δ mutation is not caused by reduced levels of cytoplasmic Pi. by Mamoru Miyasaka (9187916)

“…Cells were grown and spotted, as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0236520#pone.0236520.g001" target="_blank">Fig 1B</a>, in YPGA (galactose) or YPDA (glucose) medium with either 20 mM Pi or 50 mM Pi and then incubated at 30°C for 1.5 d. …”

Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation by Kai-li Liu (11378101)

“…Furthermore, by western blot analysis, compound <b>8m</b> effectively activated caspase 3 and decreased the expressions of GP-100, tyrosinase, eIF5A2, MMP2, and MMP9. …”

Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation by Kai-li Liu (11378101)

“…Furthermore, by western blot analysis, compound <b>8m</b> effectively activated caspase 3 and decreased the expressions of GP-100, tyrosinase, eIF5A2, MMP2, and MMP9. …”

Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation by Kai-li Liu (11378101)

“…Furthermore, by western blot analysis, compound <b>8m</b> effectively activated caspase 3 and decreased the expressions of GP-100, tyrosinase, eIF5A2, MMP2, and MMP9. …”

Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation by Kai-li Liu (11378101)

“…Furthermore, by western blot analysis, compound <b>8m</b> effectively activated caspase 3 and decreased the expressions of GP-100, tyrosinase, eIF5A2, MMP2, and MMP9. …”

Temporal and spatial variation of potassium balance in agricultural land at national and regional levels in China by Yingxia Liu (792213)

“…<div><p>Linking potassium (K) balance to soil fertility creates a valuable indicator for sustainability assessment in agricultural land-use systems. …”

Activation of the AMPK/mTOR signaling pathway correlates with curcumin-activated autophagy to restore D-gal-induced tight junction damage in SCs. by Chen Xue (699418)

Hemodynamic parameters. by Paulina Kania-Olejnik (19797617)

“…Anteroposterior diameter increased from 36.5±5.0mm to 38.4±5.5mm (<i>p</i> = 0.05). TA contraction decreased from 7±2% in SR to 2±1% in AF (p = 0.001). …”

Tricuspid annular dimensions. by Paulina Kania-Olejnik (19797617)

“…Anteroposterior diameter increased from 36.5±5.0mm to 38.4±5.5mm (<i>p</i> = 0.05). TA contraction decreased from 7±2% in SR to 2±1% in AF (p = 0.001). …”