Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

Temporal profiles of the key BO-NN features. by Julia Berezutskaya (9080269)

“…Right plot show the gradual decrease in the TM tuning for the features highlighted in <b>c</b> as well as the gradual increase in the temporal response profile (i.e. optimal shifts for the prediction of the key BO-NN features using Praat features shown in <b>a</b>). …”

OPG147 has no effect on TBK1 or IRF3-mediated ISRE activation and HT-DNA-induced signaling. by Xue-Mei Yi (18851202)

Anatomical confirmation of drug injection sites. by Diana Amorim (662998)

The mean <i>z</i>-coordinate error decreasing percentages (%) of SSI-RIK compared to EM-SFM, CSF and RIK, when the sequence sizes vary from 15 to 50 with an equal interval 5. by Ya-Ping Wang (44525)

“…<p>The mean <i>z</i>-coordinate error decreasing percentages (%) of SSI-RIK compared to EM-SFM, CSF and RIK, when the sequence sizes vary from 15 to 50 with an equal interval 5.…”

Least squares mean (LSM) + standard error (SE) of C3 concentration, ACH50 and CH50 values in different haplotypic combinations among 354 Chinese Holstein cows. by Yonghui Wang (287491)

No effects of trehalose treatment in mitochondria length in HT fibroblasts. by Collin M. MacLeod (17512385)

Optogenetic Recruitment of Dorsal Raphe Serotonergic Neurons Acutely Decreases Mechanosensory Responsivity in Behaving Mice by Guillaume P. Dugué (620333)

“…<i>In vivo</i>, the photoactivation of dorsal raphe serotonergic neurons gave rise to a prominent light-evoked field response that displayed some sensitivity to a 5-HT1A agonist, consistent with autoreceptor inhibition of raphe neurons. …”

Image_1_Decrease in Serum Urate Level Is Associated With Loss of Visceral Fat in Male Gout Patients.tif by Zijing Ran (11429935)

“…</p>Results<p>ULT resulted in a mean (standard deviation) decrease in SU level (464.22 ± 110.21 μmol/L at baseline, 360.93 ± 91.66 μmol/L at the final visit, p <0.001) accompanied by a decrease in median (interquartile range) VFA [97.30 (81.15–118.55) at baseline, 90.90 (75.85–110.05) at the final visit, p < 0.001]. …”

Serotonin deficiency decreases calcium transporters expression in the mammary gland on d 10 of lactation. by Jimena Laporta (383836)

Factors associated with abnormal left ventricular ejection fraction (decreased or increased) in patients with sepsis in the intensive care unit by Dong Geum Shin (6019568)

“…<div><p>Background</p><p>Sepsis-induced cardiomyopathy (SIC) is known to show cardiac dysfunction in patients with sepsis. Both a decrease or an increase in ejection fraction (EF), an indicator of cardiac function, can occur. …”

Phytoplankton community mean cell size decreases with temperature and increases with dilution rate. by Kalista Higini Peter (296566)

Absorbed lifetime and 50-y projected doses to selected organs. by Martin Šefl (11607984)

Serotonin levels, in small intestine, are decreased in <i>iuGC</i> animals at 3 months old. by Fátima Ramalhosa (3095712)

Rate-limiting enzymes tyrosine hydroxylase (catecholamines) and tryptophan hydroxylase (5-HT) post-stress. by C. Brad Wilson (468614)

“…<p>Tyrosine hydroxylase elevation in the PFC (A) and hippocampus (B) substantiated the findings of elevated levels of NE and DA, while down-regulated tryptophan hydroxylase in the PFC (C) and hippocampus (D) confirmed decreased levels of 5-HT. All data are presented as mean ± SEM. …”

5-HT-induced cardiomyocyte injury required the presence GC or NE <i>in vitro</i>. by Wang Xinxing (523139)

“…</b> The cell viability of cardiomyocytes treated with 10⁻⁸ M 5-HT and 10⁻⁶ M GC decreased significantly compared with the control. …”

Production of O₂^ꜙ, NO and cyclic GMP by 5-HT. by Marie Billaud (261506)

“…C, as measured by Elisa kit, basal cyclic GMP content (black column) was decreased by 5-HT (white column) whereas it was increased when PEG-SOD and PEG-catalase were added to 5-HT (light grey column). …”

5-HT₇Dro knock-down results are consistent with pharmacological studies. by Jaime Becnel (218896)

“…C) The activity of male flies carrying either the 5-HT₇Dro-GAL4 element (GAL4, white bar), the UAS-sym-p5-HT₇RNAi element (UAS-RNAi, black bar), or both (F1, gray bar) was measured using the DAMS system for five days. …”

Genetic deletion of P2rx7 leads to the alteration of NA and 5-HT levels (A, B), elevation of³H-Citalopram binding sites and 5-HT uptake (C) in the mouse hippocampus. by Cecilia Csölle (425362)

“…<p>A, B/NA and 5-HT levels were analyzed using HPLC in the hippocampus of naive and LPS (1 mg/kg)-treated P2rx7+/+ and P2rx7−/− mice. …”