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Dynorphin Neuropeptides Decrease Apparent Proton Affinity of ASIC1a by Occluding the Acidic Pocket
Published 2021“…We confirmed experimentally that the interaction is predominantly driven by electrostatic forces, and using noncanonical amino acids as photo-cross-linkers, we identified 16 residues in ASIC1a contributing to Big Dyn binding. …”
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Dynorphin Neuropeptides Decrease Apparent Proton Affinity of ASIC1a by Occluding the Acidic Pocket
Published 2021“…We confirmed experimentally that the interaction is predominantly driven by electrostatic forces, and using noncanonical amino acids as photo-cross-linkers, we identified 16 residues in ASIC1a contributing to Big Dyn binding. …”
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Decreased vagal activity and deviation in sympathetic activity precedes development of diabetes
Published 2020“…In Cox analysis, as SDNN, RMSSD, and normalized HF tertiles increased, the risk of diabetes decreased [hazard ratios (95% confidence intervals) of tertile 3: 0.81 (0.70-0.95), 0.76 (0.65-0.90) and 0.78 (0.67-0.91), respectively], whereas the risk of diabetes increased in the case of heart rate, normalized LF, and LF/HF ratio [hazard ratios (95% confidence intervals) of tertile 3: 1.41 (1.21-1.65), 1.32 (1.13-1.53), and 1.31 (1.13-1.53), respectively] after adjusting for age, sex, body mass index, smoking, drinking, systolic blood pressure, lipid level, c-reactive protein, and homeostasis model assessment of insulin resistance.…”
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MMP-2 production is decreased following ALK5 inhibition.
Published 2020“…<p>MMP-2 production was decreased in co-cultures treated with 1 μM A83-01 compared to DMSO-treated controls, as detected via ELISA. …”
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PI+ CD3+ T cells decrease at day 14 after IR while PI+ CD3- cells decrease at all time points.
Published 2024Subjects: -
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Table1_CLEC16A variants conferred a decreased risk to allergic rhinitis in the Chinese population.DOCX
Published 2022“…</p><p>Methods: We applied Agena MassARRAY technology platform to genotype five single nucleotide polymorphisms (SNPs) located in CLEC16A in 1004 controls and 995 cases. …”
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Table1_CLEC16A variants conferred a decreased risk to allergic rhinitis in the Chinese population.DOCX
Published 2022“…</p><p>Methods: We applied Agena MassARRAY technology platform to genotype five single nucleotide polymorphisms (SNPs) located in CLEC16A in 1004 controls and 995 cases. …”
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Osr1 heterozygous mice experienced decreased bile acid synthesis in the liver.
Published 2022“…<p>(A). Osr1 male mice had a decreased trend of hepatic bile acid compared to WT mice. …”
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