Proposed metabolic framework for taxane biosynthesis in the <i>Taxus</i> root. by Da Cheng Hao (216777)

“…<p>The committed step of Taxol (paclitaxel) biosynthesis is catalyzed by taxa-4(5),11(12)-diene synthase (TS), a diterpene cyclase responsible for transforming the ubiquitous isoprenoid intermediate geranylgeranyl diphosphate (GGPP) to the parent olefin with a taxane skeleton. …”

Levelt’s laws. by Pantelis Leptourgos (9767840)

“…<p>The circular inference model qualitatively reproduces the 4 Levelt’s propositions (here: <i>w</i>_<i>S</i> = 0.9; <i>a</i>_<i>P</i> = 1; <i>r</i>_<i>on</i> = <i>r</i>_<i>off</i> = 0.5). …”

Tau exon 10 alternative splicing and tauopathies-1 by Fei Liu (21082)

“…The first half of exon 10 has three exonic splicing enhancers (SC35-like, PPE and ACE). A central exon splicing silencer (ESS) separates the 5' ESE elements from a less characterized ESE at the 3'-end of exon 10. …”

The distribution of migratory microglial cells and the association between mRNA levels and the number of migrated microglial cells during retinal degeneration in RCS rats. by Yong Liu (6908)

“…(B) mRNA levels of MFG-E8 and integrin αυ showed more significant linear regression with the migration of microglial cells than the integrin β5. (C) mRNA level of CD11b was significantly associated with the migration of microglial cells and IL-1β and TNF-α showed a modestly linear regression, but the association between mRNA levels of MCP-1 and microglial cells was slightly negative, which might be owed to a dramatic reduction of apoptotic cells and a possible decrease in the phagocytic activity (or requirement) of microglial cells in the ONL.…”

Tau exon 10 alternative splicing and tauopathies-0 by Fei Liu (21082)

“…The first half of exon 10 has three exonic splicing enhancers (SC35-like, PPE and ACE). A central exon splicing silencer (ESS) separates the 5' ESE elements from a less characterized ESE at the 3'-end of exon 10. …”

Organization and structure of adult neurogenic niches in ENU-exposed animals. by Vivian Capilla-Gonzalez (336046)

“…<p>(A) Protocol of ENU administration. We administered 5 injections of ENU separated by 3 days intervals, and mice were sacrificed 45 days after the last dose. …”

Prostaglandin E(PGE) does not affect total proteoglycan release by Elena V Tchetina (38723)

“…<p><b>Copyright information:</b></p><p>Taken from "Prostaglandin PGEat very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and , a gene linked to chondrocyte hypertrophy"</p><p>http://arthritis-research.com/content/9/4/R75</p><p>Arthritis Research & Therapy 2007;9(4):R75-R75.…”

Effect of the NTSR1 agonist and antagonist in AMY on CFS. by Hiroyuki Toda (564669)

“…<b><i>E</i></b>, Bilateral infusions of a NTSR1 agonist (PD149613) dissolved in 0.5 µl of saline into AMY produced a significant decrease in the freezing rate at a concentration of 100 µM at the second exposure (n = 7 – 8 rats per all groups; *<i>p</i><0.05 vs. saline or DMSO control). …”

Accuracy and error function vs noise intensity for threshold spoiling and learning resonance. by Russell Bates (737753)

“…Here we see 3 curves for various values of threshold spoiling, <i>T</i> = 0, 0.5, 1.1. The blue line 1 shows the case for zero threshold spoiling, here we see perfect accuracy for no noise, as would be expected but a sharp decrease with the addition of noise. …”

(CASE 1) quantitative development of model properties with time. by Xiao Fu (74654)

“…<p>(A) Average oxygen tension decreased with increasing occlusion events despite occasional small increases, and had an overwhelming drop near the end of simulation. …”

Table 2_Impact of chemoradiotherapy for first primary lung cancer on the prognosis and re-chemoradiotherapy sensitivity of second primary lung cancer.docx by Zhe Chen (196097)

“…</p>Methods<p>This cohort study analyzed data from 23,827 patients who underwent FPLC surgery during 1973–2021, drawn from the Surveillance, Epidemiology, and End Results database. Among these, 5,302 FPLC patients developed SPLC within 5 years of their initial diagnosis. …”

Personal protective equipment simulation training is associated with lower COVID-19 infection among healthcare workers by Thomaz Bittencourt Couto (15216931)

“…A total of 5,502 (77.0%) professionals were trained: 3,012 (54.7%) through online training, 691 (12.6%) through face-to-face training, and 1,799 (32.7%) through both strategies. …”

Data Sheet 1_Impact of chemoradiotherapy for first primary lung cancer on the prognosis and re-chemoradiotherapy sensitivity of second primary lung cancer.xlsx by Zhe Chen (196097)

“…</p>Methods<p>This cohort study analyzed data from 23,827 patients who underwent FPLC surgery during 1973–2021, drawn from the Surveillance, Epidemiology, and End Results database. Among these, 5,302 FPLC patients developed SPLC within 5 years of their initial diagnosis. …”

Table 3_Impact of chemoradiotherapy for first primary lung cancer on the prognosis and re-chemoradiotherapy sensitivity of second primary lung cancer.docx by Zhe Chen (196097)

“…</p>Methods<p>This cohort study analyzed data from 23,827 patients who underwent FPLC surgery during 1973–2021, drawn from the Surveillance, Epidemiology, and End Results database. Among these, 5,302 FPLC patients developed SPLC within 5 years of their initial diagnosis. …”

Table_1_Relevance of PUFA-derived metabolites in seminal plasma to male infertility.xlsx by Xiangfeng Chen (1548517)

“…In men with normozoospermia, higher levels of 7(R)-MaR1 (HR: 0.4 (95% CI [0.24, 0.64]) and 11,12-DHET (0.36 (95% CI [0.21, 0.58]) were significantly associated with a decreased risk of infertility, while higher levels of 17(S)-HDHA (HR: 2.32 (95% CI [1.44, 3.79]), LXA5 (HR: 8.38 (95% CI [4.81, 15.24]), 15d-PGJ2 (HR: 1.71 (95% CI [1.06, 2.76]), and PGJ2 (HR: 2.28 (95% CI [1.42, 3.7]) correlated with an increased risk of infertility. …”

Image_1_Relevance of PUFA-derived metabolites in seminal plasma to male infertility.jpeg by Xiangfeng Chen (1548517)

“…In men with normozoospermia, higher levels of 7(R)-MaR1 (HR: 0.4 (95% CI [0.24, 0.64]) and 11,12-DHET (0.36 (95% CI [0.21, 0.58]) were significantly associated with a decreased risk of infertility, while higher levels of 17(S)-HDHA (HR: 2.32 (95% CI [1.44, 3.79]), LXA5 (HR: 8.38 (95% CI [4.81, 15.24]), 15d-PGJ2 (HR: 1.71 (95% CI [1.06, 2.76]), and PGJ2 (HR: 2.28 (95% CI [1.42, 3.7]) correlated with an increased risk of infertility. …”

Table_2_Relevance of PUFA-derived metabolites in seminal plasma to male infertility.docx by Xiangfeng Chen (1548517)

“…In men with normozoospermia, higher levels of 7(R)-MaR1 (HR: 0.4 (95% CI [0.24, 0.64]) and 11,12-DHET (0.36 (95% CI [0.21, 0.58]) were significantly associated with a decreased risk of infertility, while higher levels of 17(S)-HDHA (HR: 2.32 (95% CI [1.44, 3.79]), LXA5 (HR: 8.38 (95% CI [4.81, 15.24]), 15d-PGJ2 (HR: 1.71 (95% CI [1.06, 2.76]), and PGJ2 (HR: 2.28 (95% CI [1.42, 3.7]) correlated with an increased risk of infertility. …”

Clinical Features and Management of Patients Assessed by Cardiology Teleconsultation in the Brazilian Region with the Highest Number of Isolated Cities by Tarso Augusto Duenhas Accorsi (5379113)

“…The attendance rate was 85.7% (53.1% female, mean age: 54.2±6.5 years). The main reasons for referral were cardiovascular symptoms (58.1%) and risk factors among asymptomatic patients (13.3%). …”

Table_3_Relevance of PUFA-derived metabolites in seminal plasma to male infertility.docx by Xiangfeng Chen (1548517)

“…In men with normozoospermia, higher levels of 7(R)-MaR1 (HR: 0.4 (95% CI [0.24, 0.64]) and 11,12-DHET (0.36 (95% CI [0.21, 0.58]) were significantly associated with a decreased risk of infertility, while higher levels of 17(S)-HDHA (HR: 2.32 (95% CI [1.44, 3.79]), LXA5 (HR: 8.38 (95% CI [4.81, 15.24]), 15d-PGJ2 (HR: 1.71 (95% CI [1.06, 2.76]), and PGJ2 (HR: 2.28 (95% CI [1.42, 3.7]) correlated with an increased risk of infertility. …”

Table 1_Impact of chemoradiotherapy for first primary lung cancer on the prognosis and re-chemoradiotherapy sensitivity of second primary lung cancer.docx by Zhe Chen (196097)

“…</p>Methods<p>This cohort study analyzed data from 23,827 patients who underwent FPLC surgery during 1973–2021, drawn from the Surveillance, Epidemiology, and End Results database. Among these, 5,302 FPLC patients developed SPLC within 5 years of their initial diagnosis. …”