Secondary metabolites from <i>Gentiana cruciata</i> L. and their anti-inflammatory and analgesic activities by Rima Konya (14075753)

“…<p>A previously unreported secoiridoid glycoside, cruciatoside (<b>1</b>) was isolated from the aerial parts of <i>Gentiana cruciata</i> L. along with ten known compounds eustomoside (<b>2</b>), eustomorusside (<b>3</b>), gentiopicroside (<b>4</b>), 6'-<i>O</i>-β-D-glucopyranosyl gentiopicroside (<b>5</b>), loganic acid (<b>6</b>), isoorientin (<b>7</b>), isovitexin (<b>8</b>), isovitexin 2''<i>-(E)-</i>ferulate (<b>9</b>), mangiferin (<b>10</b>), and 2-methyl-inositol (<b>11</b>). …”

MPs^PPARα+/+-induced EPC differentiation and <i>in vitro</i> angiogenesis of mature ECs involve NF-κB pathway activation. by Tarek Benameur (196206)

“…<p>(<b>A</b>) Western blot showing that MPs^PPARα+/+ induced I-κB phosphorylation on activator sites (Ser32/36) in EPCs, indicating that NF-κB pathway is activated. …”

DNMT1-mediated demethylation of lncRNA MEG3 promoter suppressed breast cancer progression by repressing Notch1 signaling pathway by Tingting Pan (4735617)

“…Functionally, treatment of breast cancer cells with the DNA methylation inhibitor 5-AzadC as well as silencing of DNA methyltransferase-1 (DNMT1) could decrease the abnormal hypermethylation of the MEG3 promoter, reverse MEG3 expression, inhibit cell proliferation and promote cell apoptosis. …”

Identification of Differentially-Expressed Genes Associated with Pistil Abortion in Japanese Apricot by Genome-Wide Transcriptional Analysis by Ting Shi (3955)

“…<div><p>The phenomenon of pistil abortion widely occurs in Japanese apricot, and imperfect flowers with pistil abortion seriously decrease the yield in production. Although transcriptome analyses have been extensively studied in the past, a systematic study of differential gene expression has not been performed in Japanese apricot. …”

Evolutionary dynamics of iPD-population consisting of two types of players: With WSLS and AllD strategies. by Anton M. Unakafov (5706560)

“…<p>(A) Initially, both types have the same frequency, but after 40 generations the fraction of WSLS-players <i>x</i>₁(<i>t</i>) converges to 0 for probabilities to see partner’s choice <i>p</i>_see = 0.0, 0.2 and to 1 for <i>p</i>_see = 0.4, 0.5. …”

Effect of Vitrification on the MicroRNA Transcriptome in Mouse Blastocysts by Xueming Zhao (400630)

“…Of these, the expression levels of five miRNAs differed significantly: in the vitrified blastocysts, four miRNAs (mmu-miR-199a-5p, mmu-miR-329-3p, mmu-miR-136-5p and mmu-miR-16-1-3p) were upregulated, and one (mmu-miR-212-3p) was downregulated. …”

FDG PET parameters and survival curves. by Julien Ganem (7490378)

“…<p>Survival curves using the Kaplan-Meier method. <b>(a)</b> PFS was longer for patients with low TLG₂ (HR = 2.8, 95%CI 1.3–5.9, p< 0.01). …”

Loss of FHL2 reduces intestinal polyp multiplicity. by Charlotte Labalette (365229)

“…<p>(A) Representative images of intestines from 11-month-old <i>Apc^Δ14/+FHL2^+/+</i> and <i>Apc^Δ14/+FHL2^−/−</i> mouse. …”

Comparison of two physiotherapy treatments in reducing pain and increasing functional autonomy of elderly patients with gonarthrosis by Stela Freitas Raymundo (12817830)

“…Similarly, there was significant decrease (p<0.001) in the level of pain in both EG1 (Δ=5.09) and EG2 (Δ=7.1). …”

Methylation profiling in control and Tet tcKO retinas. Related to Fig 6. by Ismael Hernández-Núñez (10128242)

“…<p><b>(A)</b> Graphic displaying results of WGBS and bACE-seq to distinguish 5mC and 5hmC marks. …”

Advanced assessment of ductile fracture in steel by X-ray computed tomography by Fabien Léonard (463224)

Manager's Discretionary Power and Comparability of Financial Reports: An Analysis of the Regulatory Transition Process in Brazilian Accounting by Alex Mussoi Ribeiro (12830273)

Annual distribution of IG-ralated AE reports. by Shaozhi Liu (13720340)

“…In pregnant women, hypoglycaemia (IC025 = 4.25) was detected as a strong signal, hypoglycaemia neonatal (IC025 = 2.96) as a medium signal, while ketoacidosis (IC025 = 0.76), decreased insulin requirement (IC025 = 0.24), and underweight (IC025 = 0.09) were identified as weak signals. …”

Proportion of AEs by SOCs in pregnant women. by Shaozhi Liu (13720340)

“…In pregnant women, hypoglycaemia (IC025 = 4.25) was detected as a strong signal, hypoglycaemia neonatal (IC025 = 2.96) as a medium signal, while ketoacidosis (IC025 = 0.76), decreased insulin requirement (IC025 = 0.24), and underweight (IC025 = 0.09) were identified as weak signals. …”

Experimental strategy and global gene expression dynamics. by Romuald Parmentier (4280983)

“…Note the rapid increase in the number of genes expressed per cell between 5 h and 24 h and the slow decrease after a plateau between 24 h and 72 h. …”

MAB21L2 wild-type and mutant protein studies. by Brett Deml (696234)

“…</b> Protein stability assays with cycloheximide showed a more rapid decrease in the amount of Arg51Gly and Arg51_Phe52del mutant proteins in comparison to wild-type protein. …”

Data_Sheet_6_Topic Application of the Probiotic Streptococcus dentisani Improves Clinical and Microbiological Parameters Associated With Oral Health.PDF by María D. Ferrer (8722935)

“…Fifty nine volunteers were enrolled in the study and randomly assigned to a treatment or placebo group. The treatment consisted of a bucco-adhesive gel application (2.5 10⁹ cfu/dose) with a dental splint for 5 min every 48 h, for a period of 1 month (i.e., 14 doses). …”

Data_Sheet_4_Topic Application of the Probiotic Streptococcus dentisani Improves Clinical and Microbiological Parameters Associated With Oral Health.PDF by María D. Ferrer (8722935)

“…Fifty nine volunteers were enrolled in the study and randomly assigned to a treatment or placebo group. The treatment consisted of a bucco-adhesive gel application (2.5 10⁹ cfu/dose) with a dental splint for 5 min every 48 h, for a period of 1 month (i.e., 14 doses). …”

Data_Sheet_2_Topic Application of the Probiotic Streptococcus dentisani Improves Clinical and Microbiological Parameters Associated With Oral Health.PDF by María D. Ferrer (8722935)

“…Fifty nine volunteers were enrolled in the study and randomly assigned to a treatment or placebo group. The treatment consisted of a bucco-adhesive gel application (2.5 10⁹ cfu/dose) with a dental splint for 5 min every 48 h, for a period of 1 month (i.e., 14 doses). …”

NIR fluorescence lifetime FRET of TfnR-Tfn complexes in normal vs. cancer cells using time-domain, wide-field macroscopic imaging <i>in vitro.</i> by Ken Abe (488464)

“…(D) Sensitivity of FD% is consistent across 1×10⁵ to 1×10⁴ cells (Table S6 in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0080269#pone.0080269.s001" target="_blank">File S1</a>). …”