DataSheet1_Adenosine Kinase Inhibition Prevents Severe Acute Pancreatitis via Suppressing Inflammation and Acinar Cell Necroptosis.docx by Shukun Sun (11510686)

“…</p><p>Methods: To establish an experimental SAP model, male C57BL/6 mice were intraperitoneally injected with cerulein (50 μg/kg, seven doses at hourly intervals) and LPS (10 mg/kg, at the last cerulein injection). For ADK inhibition, ABT702 (1.5 mg/kg) was intraperitoneally injected 1 h before cerulein treatment. …”

Data_Sheet_1_Measuring the effect of the anti-nerve growth factor antibodies bedinvetmab and frunevetmab on quality of life in dogs and cats with osteoarthritis using a validated h... by Jacqueline Reid (7400972)

“…</p>Methods<p>Animals received bedinvetmab (dogs) at 0.5–1 mg/kg or frunevetmab (cats) at 1–2.8 mg/kg by subcutaneous injection on days 0, 28 and 56 and owners completed QOL assessments within 48 hours of day 0 and on days 14, 28, 56, 63 and 70 using a study-specific app.…”

Data Sheet 1_Naringenin attenuates slow-transit constipation by regulating the AMPK/mTOR/ULK1 signalling pathway: in vivo and in vitro studies.zip by Yahui Wang (1305345)

“…In vivo, male C57BL/6 mice were administered loperamide (10 mg/kg) to establish a constipation model and then treated with NAR (75/150/300 mg/kg) for 2 weeks. …”

Data_Sheet_1_Measuring the effect of the anti-nerve growth factor antibodies bedinvetmab and frunevetmab on quality of life in dogs and cats with osteoarthritis using a validated h... by Jacqueline Reid (7400972)

“…</p>Methods<p>Animals received bedinvetmab (dogs) at 0.5–1 mg/kg or frunevetmab (cats) at 1–2.8 mg/kg by subcutaneous injection on days 0, 28 and 56 and owners completed QOL assessments within 48 hours of day 0 and on days 14, 28, 56, 63 and 70 using a study-specific app.…”

Image_1_Transcriptome Analysis of Effects of Folic Acid Supplement on Gene Expression in Liver of Broiler Chickens.jpg by Yujie Zhang (399434)

“…First, 405 differentially expressed genes (DEGs), including 157 significantly upregulated and 248 downregulated, were detected between the control group (C) and the 5 mg folic acid group (M). Second, 68 upregulated DEGs and 142 downregulated DEGs were determined between C group and 10 mg folic acid group (H). …”

Data Sheet 2_Silicon and potassium synergistically alleviate salt stress and enhance soil fertility, nutrition, and physiology of passion fruit seedlings.pdf by Alicia Camila Zeferino da Silva (22465285)

“…</p>Methods<p>The experiment was conducted in a greenhouse using a completely randomized 4 × 2 + 2 factorial design with five replicates. Four doses of silicic acid (1.26, 2.52, 3.78, and 5.04 g dm^-3) and two potassium doses (150 and 600 mg dm^-3) were tested, with two controls (saline and non-saline water). …”

DataSheet1_Defining Quantitative Targets for Topsoil Organic Carbon Stock Increase in European Croplands: Case Studies With Exogenous Organic Matter Inputs.docx by Elisa Bruni (12085235)

“…Among them, current soil organic carbon (SOC) concentration losses in croplands (0.5% yr⁻¹ on average at 20 cm depth) should be reversed to an increase of 0.1–0.4% yr⁻¹ by 2030. …”

Data_Sheet_3_Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway.docx by Burak I. Arioz (6904232)

“…We assessed the effects of melatonin on behavioral changes and inflammatory cytokine expression in hippocampus of mice in LPS-induced DLB, as well as its effects on NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome activation, oxidative stress and pyroptotic cell death in murine microglia in vitro. Intraperitoneal 5 mg/kg dose of LPS was used to mimic depressive-like behaviors and melatonin was given at a dose of 500 mg/kg for 4 times with 6 h intervals, starting at 2 h before LPS administration. …”

Data_Sheet_1_Interaction of energy and sulfur microbial diet and smoking status with polygenic variants associated with lipoprotein metabolism.PDF by Haeng Jeon Hur (6808157)

“…The High-PRS with four SNPs, namely ZPR1_rs3741297, CETP_rs708272, BUD13_rs180327, and ALDH1A2_rs588136, and that with the 11q23.3 haplotype were positively associated with hypo-HDL-C by about 3 times, which was a 2.4-fold higher association than the PRS of 24 SNP with p < 5×10⁻⁸. The risk alleles of CETP_rs708272 and ALDH1A2_rs588136 were linked to increased expression in the heart and decreased in the brain, respectively. …”

Table_1_Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway.docx by Burak I. Arioz (6904232)

“…We assessed the effects of melatonin on behavioral changes and inflammatory cytokine expression in hippocampus of mice in LPS-induced DLB, as well as its effects on NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome activation, oxidative stress and pyroptotic cell death in murine microglia in vitro. Intraperitoneal 5 mg/kg dose of LPS was used to mimic depressive-like behaviors and melatonin was given at a dose of 500 mg/kg for 4 times with 6 h intervals, starting at 2 h before LPS administration. …”

IFNγ and CXCL10 has a key role in CD20-TCB T cell recruitment. by Floriana Cremasco (5580266)

“…<p>a-b) Top: Representative histological staining of WSU DLCL2 tumors 24h post second treatment (0.5 mg/kg CD20-TCB or suitable vehicle i.v.). Bottom: Quantification of total signal intensity/mm² from histological images of vehicle <i>vs</i> CD20-TCB treatment. …”

Table 1_Case report: Clinical and immunohistochemical manifestations of suspected Sjogren's disease in a dog.xlsx by Brett D. Story (20344653)

“…Clinical signs including ocular discharge and mandibular salivary gland enlargement markedly improved following oral immunomodulatory therapy with prednisone (1 mg/kg/d, tapered over 2 months) and long-term leflunomide (2 mg/kg/d). …”

Data_Sheet_1_Duchenne Muscular Dystrophy With Low Acidic α-Glucosidase Activity: Two Case Reports and Literature Review.ZIP by Xiufang He (12704855)

“…</p>Case Presentation<p>Case 1 patient was a 2-month-old boy who presented with an extremely high serum CK level (5,480∼11,880 U/L) and low GAA activity (2.72 nmol/1 h/mg). …”

Data_Sheet_1_Efficacy and Safety of Colchicine in Post–acute Myocardial Infarction Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.doc by Carlos Diaz-Arocutipa (10938975)

“…Subgroup analyses by colchicine dose (0.5 vs. 1 mg/day), time of follow-up (<1 vs. ≥1 year), and treatment duration (≤30 vs. >30 days) showed no changes in the overall findings.…”

Ototopical drops containing a novel antibacterial synthetic peptide: Safety and efficacy in adults with chronic suppurative otitis media by Nanno F. A. W. Peek (8708166)

“…The optimal dose (0.5 mg of peptide/ml) was selected for the subsequent phase II^a study. …”

Data_Sheet_1_Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway.docx by Burak I. Arioz (6904232)

“…We assessed the effects of melatonin on behavioral changes and inflammatory cytokine expression in hippocampus of mice in LPS-induced DLB, as well as its effects on NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome activation, oxidative stress and pyroptotic cell death in murine microglia in vitro. Intraperitoneal 5 mg/kg dose of LPS was used to mimic depressive-like behaviors and melatonin was given at a dose of 500 mg/kg for 4 times with 6 h intervals, starting at 2 h before LPS administration. …”

DataSheet_1_Chitosan Protects Immunosuppressed Mice Against Cryptosporidium parvum Infection Through TLR4/STAT1 Signaling Pathways and Gut Microbiota Modulation.docx by Sajid Ur Rahman (9101445)

“…Immunosuppressed C57BL/6 mice were divided into five treatment groups. The unchallenged mice received a basal diet (control), and three groups of mice challenged with 1 × 10⁶ C. parvum received a basal diet, a diet supplemented with 50 mg/kg/day paromomycin, and 1 mg/kg/day chitosan, and unchallenged mice treated with 1 mg/kg/day chitosan. …”

ADE curve in U937 cells using 4G2 staining. by Adam D. Wegman (11750252)

“…Finally, we show that over the course of primary dengue infection, the expression of FcγRI (CD64) increases during the period of acute viremia, while FcγRIIa (CD32) and FcαR (CD89) expression decreases, thereby further limiting the ability of IgA to facilitate ADE in the presence of DENV. …”

Low levels of dehydroepiandrosterone sulfate are associated with the risk of developing cardiac autonomic dysfunction in elderly subjects by Marina de Paiva Lemos (4704679)

“…The parasympathetic modulation of HRV was lower in both the MA (244.2 ± 58.0 ms2) and OA (172.8 ± 37.9 ms2) groups in comparison with the YA group (996.0 ± 255.4 ms2; p < 0.05), while serum DHEA-S levels were significantly lower in both the MA (91.2 ± 19.6 mg/dL) and OA (54.2 ± 17.7 mg/dL) groups compared to the YA group (240.0 ± 50.8 mg/dL; p < 0.05). …”

Immediate Changes in Peripapillary Retinal Vasculature after Intraocular Pressure Elevation -an Optical Coherence Tomography Angiography Study by Xiaolei Wang (139592)

“…In group 2 with an increased IOP from 5 mmHg to 10 mmHg, the reduction of vessel density in the RPC was more significant than that of the entire retina (RPC vs. retina: 7.1 ± 10.0% vs. 3.0 ± 4.4%, <i>P</i> = .006).</p> <p><b>Conclusions</b>: LPI-induced IOP spikes resulted in a decrease in retina vessel density with PACS eyes by OCTA. …”