Substitution of F595 to Ala has an inhibitory effect on the constitutive activity of other JAK2 oncogenic mutants. by Alexandra Dusa (247246)

“…<p>(A) JAK2 K539L, T875N and R683G all induce constitutive activation of JAK2, however all three mutants display a marked decrease in STAT5 transcriptional activity in γ-2A cells when the F595A mutation is also introduced. …”

YC-1 Reverses Retinal Reactive Gliosis and Retinal Neovascularization, <i>in vivo</i> and <i>in vitro</i>. by Michael DeNiro (297385)

“…Whereas YC-1 exhibited a significant and a dose-dependent decrease in neovascular sprouts number [B]. …”

DataSheet1_Silencing of crustacean hyperglycemic hormone gene expression reveals the characteristic energy and metabolic changes in the gills and epidermis of crayfish Procambarus... by Wen-Feng Li (550661)

“…The decline in TCA cycle intermediates pointed to a potential downregulation of the cycle, whereas a decrease in ketone bodies indicated a shift towards lipid metabolism for energy production. …”

The balance of ON vs. OFF input is critical to observe feature invariance whereas compensation was observed for other parameters. by Tristan Aumentado-Armstrong (815039)

“…For A,B,C, note the negatively sloped red band indicating that a decrease/increase in the former can be compensated by an increase/decrease in the latter. …”

RO5464466 blocked the production of progeny virus and inhibited an established influenza virus infection. by Lei Zhu (16642)

“…<p>(A) Decrease of progeny virus production in cells treated with RO5464466 and other reference compounds. 12-well plates were seeded with MDCK cells at a density of 1.5×10⁵ cells per well. …”

Image_2_Reduction of Nitrate Content in Baby-Leaf Lettuce and Cichorium endivia Through the Soilless Cultivation System, Electrical Conductivity and Management of Nutrient Solution... by Giulia Conversa (5426438)

“…In both seasons, the EF/EC3.5 treatment resulted in a decline in productivity, despite a further reduction in nitrate content and a rise in product quality occurring. …”

Table_2_Reduction of Nitrate Content in Baby-Leaf Lettuce and Cichorium endivia Through the Soilless Cultivation System, Electrical Conductivity and Management of Nutrient Solution... by Giulia Conversa (5426438)

“…In both seasons, the EF/EC3.5 treatment resulted in a decline in productivity, despite a further reduction in nitrate content and a rise in product quality occurring. …”

Image_1_Reduction of Nitrate Content in Baby-Leaf Lettuce and Cichorium endivia Through the Soilless Cultivation System, Electrical Conductivity and Management of Nutrient Solution... by Giulia Conversa (5426438)

“…In both seasons, the EF/EC3.5 treatment resulted in a decline in productivity, despite a further reduction in nitrate content and a rise in product quality occurring. …”

Table_1_Reduction of Nitrate Content in Baby-Leaf Lettuce and Cichorium endivia Through the Soilless Cultivation System, Electrical Conductivity and Management of Nutrient Solution... by Giulia Conversa (5426438)

“…In both seasons, the EF/EC3.5 treatment resulted in a decline in productivity, despite a further reduction in nitrate content and a rise in product quality occurring. …”

HuR regulates expression of Eph/ephrins. by Jennifer Winter (87429)

“…Quantification of bands (Against GAPDH) was performed using the Image Quant software 5.2 (lower panel). Fold increase or decrease of expression are depicted.…”

Blood clearance and subsequent in vivo degradation of BK- and JC-virus like particles (VLPs). by Jaione Simon-Santamaria (3598871)

“…<p>Mice were injected intravenously with approximately 0.5 µg of ¹²⁵I-BK-VLPs (n = 3; A, B), or ¹²⁵I-JC-VLPs (n = 5; C, D), and blood samples taken at the indicated time points and analyzed for ¹²⁵I-labeled degradation products and intact ligand <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0111762#pone.0111762-Malovic1" target="_blank">[15]</a>. …”

Pressure Dependence of the Carbon Dioxide/Cyclohexene Oxide Coupling Reaction Catalyzed by Chromium Salen Complexes. Optimization of the Comonomer-Alternating Enchainment Pathway by Donald J. Darensbourg (1317624)

“…The most active (salen)CrN₃ catalyst (H₂salen = <i>N</i>,<i>N</i>‘-bis(3-<i>tert</i>-butyl-5-methoxysalicylidene)-(1<i>R</i>,2<i>R</i>)-cyclohexenediimine), along with a [PPN][N₃] cocatalyst, exhibited a TOF of 1153 mol epoxide consumed/mol chromium·h at 80 °C and a CO₂ pressure of 34.5 bar.…”

Synaptic facilitation between tail SNs and MNs following sensitizing tail shocks declined during aging. by Andrew T. Kempsell (738294)

“…<p>A) Representative responses during depolarizing current injection in tail SNs before and 5 min after sensitizing tail shocks in mature and aged II animals. …”

Overall influence of the levels of stimulation on behavioral thresholds and latencies. by Jean-Michel Benoist (270919)

“…On average, the behavioral threshold Tβ was 44.9 (44.5–45.3)°C with a significant tendency to decrease from the proximal to the distal parts of the tail, best described by the equation Tβ = 47.4−0.014 D (F_44,1 = 12.2; p<0.01). …”

Intracellular chloride measurements by Wallace B Thoreson (5462)

“…An example of the reduction in MEQ fluorescence, indicating an increase in intracellular [Cl], produced by application of 12.1 mM Kto a cone. C. A greater decrease in MEQ fluorescence was produced by application of 69.9 mM K. …”

Heat map of the miRNAs that are regulated at different times following MCAo. by Fu Jia Liu (422650)

“…Green: downregulation; Red: upregulation. (<b>A</b>) The expression of 334 miRNAs that are statistically significant are represented in the heat map; (<b>B</b>) Cluster of miRNAs that show a decrease in expression during the progression of cerebral ischemia (rno-miR-196a, -196b, -196c, -224, -324-3p); (<b>C</b>) Cluster of miRNAs that show an increase in expression during the progression of cerebral ischemia (rno-miR-21, -142-3p/5p, -146a); (<b>D</b>) Cluster of miRNAs that show an expression which positively correlated with infarct volume during the progression of cerebral ischemia (rno-miR-206, -290, -291a-5p and -30c-1*).…”

Heat map of the miRNAs that are regulated at different times following MCAo. by Fu Jia Liu (422650)

“…Green: downregulation; Red: upregulation. (<b>A</b>) The expression of 334 miRNAs that are statistically significant are represented in the heat map; (<b>B</b>) Cluster of miRNAs that show a decrease in expression during the progression of cerebral ischemia (rno-miR-196a, -196b, -196c, -224, -324-3p); (<b>C</b>) Cluster of miRNAs that show an increase in expression during the progression of cerebral ischemia (rno-miR-21, -142-3p/5p, -146a); (<b>D</b>) Cluster of miRNAs that show an expression which positively correlated with infarct volume during the progression of cerebral ischemia (rno-miR-206, -290, -291a-5p and -30c-1*).…”

Substrate binding specificity of purified OpuAC. by Justina C. Wolters (207763)

“…<p>Binding was measured using intrinsic protein fluorescence at an OpuAC concentration of ∼0.5 µM. The following substrates were tested: proline (panel A), carnitine (panel B), proline betaine (panel C) and glycine betaine (Panel D–F). …”

Label-free real-time multi-parametric monitoring enables high content analysis. by Heinz-Georg Jahnke (122745)

“…The effect on the APD was determined for one hour after doxorubicin application and revealed a concentration dependent response with an EC₅₀ value of 17 µM (n  = 3 hCMC), (B) The impedance analysis revealed a concentration- and time-dependent decrease where IC₅₀ values could be determined for each time point (n  = 5 hCMC). …”

Inhibition of NF-κB signaling impedes TNF-α-induced increase in proliferation and angiogenic signaling. by Michael Boyle (433024)

“…(<b>B</b>) MTT assay showing a decrease in TNF-α-induced increase in proliferation, in DPSC challenged with varying concentrations of NBD domain peptide (5 and 10 µM). …”