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FLCN-deficiency leads to decreased Rho activity in sub-confluent cells and delays in wound closure.
Published 2013“…<b>B)</b> Rho activity was measured using a Rhotekin binding assay at 70% confluence. The FLCN-null UOK257 cells had a 2.5-fold decrease in active Rho levels (Rho GTP) compared to the FLCN re-expressing UOK257-2 cells (n = 3, p<0.05). …”
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Activation of GluR5 increased neuronal excitability in interneruons but decreased excitability in pyramidal neurons.
Published 2013“…Resting membrane potential for this neuron was −66.6 mV and the holding current was 66.9 pA. (H) Pooled data showed that ATPA (3 µM) increased firing rate of interneurons (n = 6) while decreased that of pyramidal neurons (n = 5). …”
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Combination metabolic therapy decreases VM-M3 cell proliferation <i>in vitro</i>.
Published 2015“…<b>(B)</b> Combining low glucose, ketone supplementation, and HBOT resulted in a marked decrease in cell proliferation which was significant from control at all time points tested. …”
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Blocking CD88 decreased ANCA antigen translocation, ANCA-induced respiratory burst and degranulation in C5a-primed neutrophils.
Published 2013“…C and D: blocking CD88 decreased C5a-primed neutrophils for ANCA-induced respiratory burst. …”
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Thrombin-induced decreased lamellipodia protrusion frequency and actin stress fiber formation.
Published 2015“…Later (27.5 min image), ventral stress fibers (SF) formed de novo in the cells, and cortical actin migrated to become transverse arc (TA) stress fibers. …”
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Decreased oscillatory flow decreases <i>klf2a</i> expression.
Published 2009“…<p>(A) RFF is decreased by alterations in heart rate. …”
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PIN1 silencing leads to decreases in the protein levels of HIF-1α.
Published 2016“…E) ATRA decreases the expression of HIF-1α and PIN1 in HCT116/5xHRE-ODD-luc cells in dose-dependent manner. …”
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Delphinidin alters VEGF-A splicing to increase VEGF-A<sub>165</sub>b and decrease total VEGF-A expression.
Published 2019“…<p><b>A)</b> Treatment of podocytes with delphinidin chloride (10 μg/ml) under normal glucose (NG; 5 mM glucose + 25 mM mannitol) and high glucose (HG; 30 mM glucose, 1 ng/ml TNFα, 1 ng/ml IL-6, and 100 nM insulin) for 48 hrs increased the protein expression of VEGF-A<sub>165</sub>b relative to total VEGF-A<sub>165</sub> (quantified in <b>B</b>; *p<0.05 vs NG, †p<0.05 vs HG; n = 3 biological repeats; One-way ANOVA with Bonferroni post-hoc test for comparison between pairs; <b>A</b>—the same blot was first probed with VEGF-A<sub>165</sub>b before stripping and reprobing with panVEGF-A). …”
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