A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity by Wesam S. Ahmed (10170053)

“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”

apoA2 correlates to gestational age with decreased apolipoproteins A2, C1, C3 and E in gestational diabetes by Manjunath Ramanjaneya (14603468)

“…</p><h3>Conclusions</h3><p dir="ltr">Apoproteins apoA2, apoC1, apoC3 and apoE are decreased in women with GDM and may have a role in inflammation, as apoA2 and C3 correlated with CRP. …”

The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neurons by Wesal Habbab (17346961)

“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”

Decreased Analgesic Requirements in Super Morbidly Versus Morbidly Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy by Hamed Elgendy (14148846)

Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle by Jinit Masania (7164239)

“…In aged HSA-mUCP1 mice, urinary MG-derived AGEs/FL ratio was decreased ca. 60% whereas there was no change in CML/FL ratio – a marker of oxidative damage. …”

Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle by Jinit, Masania

“…In aged HSA-mUCP1 mice, urinary MG-derived AGEs/FL ratio was decreased ca. 60% whereas there was no change in CML/FL ratio – a marker of oxidative damage. …”
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Investigating the Properties of Electrodeposited of Ni-P-ZrC Nanocomposite Coatings by Osama Fayyaz (17017686)

“…<p dir="ltr">Superior corrosion resistance along with higher mechanical performance is becoming a primary requirement to decrease operational costs in the industries. …”

Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex by Wesam S. Ahmed (10170053)

“…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…”

Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex by Wesam S. Ahmed (10170053)

“…<p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences <a href="https://dx.doi.org/10.3389/fmolb.2022.846996" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.846996</a>, published online 22 July 2022.…”

Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells by Nihal AlMuraikhi (6002234)

“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”

Meta-Heuristic Algorithm-Tuned Neural Network for Breast Cancer Diagnosis Using Ultrasound Images by Ahila A (18394806)

“…However, it is a challenging task to differentiate abnormal breast tissues from normal tissues because of their structure and unclear boundaries. …”

Effect of AlN nanoparticle concentration in the electrolyte on corrosion resistance and mechanical properties of the electrodeposited composite coatings by Khan, M.S.

“…The impact of corrosion is widespread, affecting structures, equipment, and infrastructure across various industries increasing the maintenance cost and thereby decreasing profit and efficiency. Nickel-based coatings are one of the most tempting options owing to their enhanced mechanical and corrosion-resistant properties. …”
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Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitn... by Vijay Ganji (8710491)

CD146, a novel target of CD44-signaling, suppresses breast tumor cell invasion by Allal Ouhtit (14153256)

“…While the exact function of CD146 in breast cancer (BC) is not completely understood, substantial evidence from our work and others support the hypothesis that CD146 is a suppressor of breast tumor progression. …”

Effect of AlN nanoparticle concentration in the electrolyte on corrosion resistance and mechanical properties of the electrodeposited composite coatings by M.S. Khan (22047413)

“…<p>The impact of corrosion is widespread, affecting structures, equipment, and infrastructure across various industries increasing the maintenance cost and thereby decreasing profit and efficiency. Nickel-based coatings are one of the most tempting options owing to their enhanced mechanical and corrosion-resistant properties. …”

A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate by Geethakumari, Anupriya M

“…Here, we report the engineering of a Bioluminescence Resonance Energy Transfer (BRET)-based SARS-CoV-2 main protease (Mpro) biosensor containing the Mpro N-terminal autocleavage sequence in tandem and a nanobody that shows an enhanced rate of Mpro-mediated proteolytic cleavage. …”
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The influence of different preparation methods on the erosion behavior of NiP-ZrO₂ nanocomposite coating by Mostafa H. Sliem (6316958)

“…The pulse-electrodeposition was the most suitable technique with a hardness value of 653HV₂₅. The erosion behavior for the different NiP-ZrO₂ coatings was investigated based on erosion duration, particles velocity, and impact angle. …”

Immunomodulatory effects of tumor Lactate Dehydrogenase C (LDHC) in breast cancer by Adviti Naik (673163)

“…Following <i>LDHC</i> knockdown, we observed an increase in the secretion of tumor-derived pro-inflammatory cytokines (IFN-γ, GM-CSF, MCP-1, CXCL1), a decrease in the soluble levels of tumor-derived immunosuppressive factors (IL-6, Gal-9) and reduced tumor cell surface PD-L1 expression. …”

miRNA-dependent regulation of STIM1 expression in breast cancer by Rashmi P. Kulkarni (18618634)

“…Our findings show that STIM1 expression is differentially regulated by the miRNA machinery in different cell types and argue for a role for this regulation in breast cancer.</p><h2>Other Information</h2><p dir="ltr">Published in: Scientific Reports<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41598-019-49629-5" target="_blank">https://dx.doi.org/10.1038/s41598-019-49629-5</a></p>…”

Modulation of SLFN11 induces changes in DNA Damage response in breast cancer by Christophe Michel Raynaud (17449906)

“…</p><h3>Conclusion</h3><p dir="ltr">To our knowledge this is the first report of the stable non-lethal increase of SLFN11 expression in a cancer cell line. Our results show that induction of SLFN11 expression can enhance DDA and DDR sensitivity in breast cancer cells and dCas9 systems may represent a novel approach to increase SLFN11 and achieve higher sensitivity to chemotherapeutic agents, improving outcome or decreasing required drug concentrations. …”