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apoA2 correlates to gestational age with decreased apolipoproteins A2, C1, C3 and E in gestational diabetes
منشور في 2021"…</p><h3>Conclusions</h3><p dir="ltr">Apoproteins apoA2, apoC1, apoC3 and apoE are decreased in women with GDM and may have a role in inflammation, as apoA2 and C3 correlated with CRP. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
منشور في 2023"…In aged HSA-mUCP1 mice, urinary MG-derived AGEs/FL ratio was decreased ca. 60% whereas there was no change in CML/FL ratio – a marker of oxidative damage. …"
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
منشور في 2023"…In aged HSA-mUCP1 mice, urinary MG-derived AGEs/FL ratio was decreased ca. 60% whereas there was no change in CML/FL ratio – a marker of oxidative damage. …"
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eIF4A inhibition prevents the onset of cytokine-induced muscle wasting by blocking the STAT3 and iNOS pathways
منشور في 2018"…Here we show that hippuristanol, a compound that impedes eIF4A in a manner distinct from PatA, similarly inhibits the iNOS/NO pathway and cytokine-induced muscle wasting. …"
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Genome-Wide Association Study of Vitamin D Deficiency in the Middle East With a Relevant Characterization of the Novel <i>SDR42E1 </i>Gene
منشور في 2023"…Cellular viability also decreased significantly after the knockout of SDR42E1 in the HCT116 cells.…"
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Addressing Challenges of Distance Learning in the Pandemic with Edge Intelligence Enabled Multicast and Caching Solution
منشور في 2022"…Due to the closure of educational institutes, work and learn from home methods have burdened the network resources and considerably decreased a viewer’s Quality of Experience (QoE). The situation calls for innovative techniques to handle the surging load of video traffic on cellular networks. …"
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Application of Fe<sub>3</sub>O<sub>4</sub> magnetite nanoparticles grafted in silica (SiO<sub>2</sub>) for oil recovery from oil in water emulsions
منشور في 2021"…An excellent %<sub>hdem</sub> 90% was achieved C<sub>oil</sub> in the range 50 e2000 mg/L. Using an MD<sub>dose</sub> as low as 10 mg/L attained a %<sub>hdem</sub> in the range of 93% - 4.3% for O/W mixtures with C<sub>oil</sub> < 2000 mg/L, which slightly decreased to ~90% for higher concentrations. …"
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A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate
منشور في 2025"…We envisage that the NB2E3 nanobody-2× Mpro biosensor engineered here will be useful in drug discovery and functional characterization of Mpro mutants in newly emerging SARS-CoV-2 variants as well as in detecting SARS-CoV-2 infection in a point-of-care testing (POCT) format.…"
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Myeloid Cells in Circulation and Tumor Microenvironment of Colorectal Cancer Patients with Early and Advanced Disease Stages
منشور في 2020"…Lastly, we found that levels of GMCs decreased, while IMCs increased in the TME with tumor budding. …"
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Changes in Blood microRNA Expression and Early Metabolic Responsiveness 21 Days Following Bariatric Surgery
منشور في 2019"…<h3>Background: </h3><p dir="ltr">Early metabolic responses following bariatric surgery appear greater than expected given the initial weight loss and coincide with improvement in diabetes. …"
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Urinary Metabolomic Markers of Protein Glycation, Oxidation, and Nitration in Early-Stage Decline in Metabolic, Vascular, and Renal Health
منشور في 2019"…We recruited 200 human subjects with early-stage health decline and healthy controls. …"
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Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans
منشور في 2021"…We then used genetic and pharmacological methods to define the features of early motor dysfunction of α-synuclein-expressing C. elegans. …"
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Effect of hexagonal on the in-plane crushing behaviour of plain weave composite hexagonal quadruple ring system
منشور في 2019"…Increasing the cell angle showed a decrease in energy absorption capability and load carrying capacity. …"
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Global pattern, trend, and cross-country inequality of early musculoskeletal disorders from 1990 to 2019, with projection from 2020 to 2050
منشور في 2024"…BackgroundThis study aims to estimate the burden, trends, forecasts, and disparities of early musculoskeletal (MSK) disorders among individuals ages 15 to 39 years. …"
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PGAP3 Associated with Hyperphosphatasia with Mental Retardation Plays a Novel Role in Brain Morphogenesis and Neuronal Wiring at Early Development
منشور في 2020"…Remarkably, morphants displayed defective neural tube formation during the early stages of nervous system development, affecting brain morphogenesis. …"
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Mechanisms behind the immediate effects of Roux-en-Y gastric bypass surgery on type 2 diabetes
منشور في 2013"…Our method involves (1) setting up a set of time-dependent equations for the concentrations of the most relevant species, (2) considering an “adiabatic” (or quasi-equilibrium) state in which the concentrations are slowly varying compared to reaction rates (and which in the present case is a postprandial state), and (3) solving for the dependent concentrations (of e.g. insulin and glucose) as an independent concentration (of e.g. …"