Flavaglines Alleviate Doxorubicin Cardiotoxicity: Implication of Hsp27 by Yohann Bernard (198579)

“…Administration of our lead compound (FL3) to mice attenuated cardiomyocyte apoptosis and cardiac fibrosis, as reflected by a 50% decrease of mortality.</p> <h3>Conclusions/Significance</h3><p>These results suggest a prophylactic potential of flavaglines to prevent doxorubicin-induced cardiac toxicity.…”

Averaged traces of laser Doppler flowmetry in C57BL/6J and IP₃R2-KO mice. by Norio Takata (49477)

“…Each experimental condition has N>5 animals. Upon 200 µA stNBM, the cerebral blood flow (CBF) showed an immediate increase, followed by a transient decrease that overshot the baseline both in WT (<b>A</b>) and KO (<b>E</b>). …”

Involvement of serine/threonine kinase type I receptors. by Lauriane Sèdes (490693)

“…Only GCs transfected with siRNA against <i>Bmpr1a</i> present a significant decrease of AMH response.…”

Following treatment with BMP-7 polarization of monocytes into M2 macrophages increases as well as expression of anti-inflammatory markers. by Crystal Rocher (500661)

“…Scale bar  = 50 µm. Histogram B shows quantitative analysis of the percentage of cells expressing CD206 with a significant increase in the ACM+BMP7 group and a significant decrease in the ACM and ACM+BMP7+Foll groups; n = 5–6. …”

Assembly of Drosophila Centromeric Chromatin Proteins during Mitosis by Barbara G. Mellone (134260)

“…Pulse-chase experiments show that CID and CENP-C levels decrease by 50% at each cell division, as predicted for semi-conservative segregation and inheritance, whereas CAL1 displays higher turnover. …”

Cas4 family proteins are 5′-3′ exonucleases. by Jing Zhang (23775)

“…A marked decrease in cleavage of the labelled oligonucleotide was observed, suggesting that Sso0001 is not highly processive, but can dissociate from substrates following each round of catalysis.…”

Lin28 increased the mammosphere formation rate and ALDH1 activity in breast cancer cells. by Yujie Liu (188278)

The Effect of Propofol on Mitochondrial Fission during Oxygen-Glucose Deprivation and Reperfusion Injury in Rat Hippocampal Neurons - Fig 3 by Haibin Wang (219428)

“…<b>Ca</b>^<b>2+</b> was dyed by the explorer Fluo-3, AM and Pluronic F-127, then its concentration was determined using a Laser Scanning Confocal Microscope. Values are represented as the mean ± SD. …”

Morphological changes of yeast (<i>Saccharomyces cerevisiae</i>) cells after treatment with vanillin. by Aya Iwaki (406491)

“…For dose-dependency, wild-type cells were grown in YPD medium containing 0.00, 0.25, 0.50, 0.75 and 1.00 mM vanillin. For time dependency, time-course data were acquired as described in (A). …”

Table_2_The Impact of Particulate Matter (PM2.5) on Human Retinal Development in hESC-Derived Retinal Organoids.XLSX by Yuxiao Zeng (770249)

“…It demonstrated that the formation rate of the hERO-derived neural retina (NR) was affected by PM2.5 in a concentration dosage-dependent manner. The areas of hEROs and the thickness of hERO-NRs were significantly reduced after PM2.5 exposure at the concentration of 25, 50, and 100 μg/ml, which was due to the decrease of proliferation and the increase of apoptosis. …”

Data_Sheet_1_The Impact of Particulate Matter (PM2.5) on Human Retinal Development in hESC-Derived Retinal Organoids.DOC by Yuxiao Zeng (770249)

“…It demonstrated that the formation rate of the hERO-derived neural retina (NR) was affected by PM2.5 in a concentration dosage-dependent manner. The areas of hEROs and the thickness of hERO-NRs were significantly reduced after PM2.5 exposure at the concentration of 25, 50, and 100 μg/ml, which was due to the decrease of proliferation and the increase of apoptosis. …”

Table_1_The Impact of Particulate Matter (PM2.5) on Human Retinal Development in hESC-Derived Retinal Organoids.XLSX by Yuxiao Zeng (770249)

“…It demonstrated that the formation rate of the hERO-derived neural retina (NR) was affected by PM2.5 in a concentration dosage-dependent manner. The areas of hEROs and the thickness of hERO-NRs were significantly reduced after PM2.5 exposure at the concentration of 25, 50, and 100 μg/ml, which was due to the decrease of proliferation and the increase of apoptosis. …”

Knockdown of NT-3 in <i>Fmr1</i> KO astrocytes rescued aberrant neuronal morphology. by Qi Yang (108283)

“…<p>A, GFP-positive astrocytes indicated the successful infection of NT-3 shRNAs. …”

Table_3_The Impact of Particulate Matter (PM2.5) on Human Retinal Development in hESC-Derived Retinal Organoids.XLSX by Yuxiao Zeng (770249)

“…It demonstrated that the formation rate of the hERO-derived neural retina (NR) was affected by PM2.5 in a concentration dosage-dependent manner. The areas of hEROs and the thickness of hERO-NRs were significantly reduced after PM2.5 exposure at the concentration of 25, 50, and 100 μg/ml, which was due to the decrease of proliferation and the increase of apoptosis. …”

Temperature gradient ddPCR for both DMD ex51-52.2 and DMD ex47-52 assays. by Ruurd C. Verheul (3111144)

Development of cisplatin-loaded hydrogels for trans-portal vein chemoembolization in an orthotopic liver cancer mouse model by Xinxiang Yang (3570470)

table1_Combining the Fecal Immunochemical Test with a Logistic Regression Model for Screening Colorectal Neoplasia.xlsx by Feiyuan Liu (10314578)

“…</p><p>Methods: A total of 4,477 participants were examined with FIT and those who tested positive (over 100 ng/ml) were followed up by a colonoscopy examination. …”

table1_Combining the Fecal Immunochemical Test with a Logistic Regression Model for Screening Colorectal Neoplasia.xlsx by Feiyuan Liu (10314578)

“…</p><p>Methods: A total of 4,477 participants were examined with FIT and those who tested positive (over 100 ng/ml) were followed up by a colonoscopy examination. …”

Long noncoding RNA <i>CA7-4</i> promotes autophagy and apoptosis via sponging <i>MIR877-3P</i> and <i>MIR5680</i> in high glucose-induced vascular endothelial cells by Xuan Zhao (356028)

“…</p> <p><b>Abbreviations</b>: 3BDO: 3-benzyl-5-([2-nitrophenoxy] methyl)-dihydrofuran-2(3H)-one; 3ʹ UTR: 3ʹ untranslated region; AGO2: argonaute RISC catalytic component 2; AMPK: AMP-activated protein kinase/protein kinase AMP-activated; BAX/BCL2L4: BCL2 associated X, apoptosis regulator; BCL2: BCL2 apoptosis regulator; CASP3: caspase 3; ceRNA: competing endogenous RNA; CTNNB1: catenin beta 1; CTNNBIP1/ICAT: catenin beta interacting protein 1; DPP4: dipeptidyl peptidase 4; FGF2/FGF-2: fibroblast growth factor 2; HG: high concentration glucose (30 mM glucose); lncRNA: long noncoding RNA; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; miRNA: microRNA; <i>MIR4778-3P</i>: microRNA 4778-3p; <i>MIR561-3P</i>: microRNA 561-3p; <i>MIR5680</i>: microRNA 5680; <i>MIR877-3P</i>: microRNA 877-3p; MTOR: mechanistic target of rapamycin kinase; Mut: mutant; NC: negative control; NG: normal concentration glucose (5.5 mM glucose); PARP1: poly(ADP-ribose) polymerase 1; qPCR: quantitative real-time PCR; RNA-FISH: RNA-fluorescence in situ hybridization; ROS: reactive oxygen species; RT-PCR: reverse transcription polymerase chain reaction; siRNA: small interfering RNA; SQSTM1: sequestosome 1; <i>TGFB2-OT1</i>: TGFB2 overlapping transcript 1; TUNEL: terminal deoxynucleotidyl transferase dUTP nick end labeling; VECs: vascular endothelial cells; WT: wild type</p>…”

Mossy fiber synaptic LTP - induced by place field specific spiking activity of dentate gyrus granule cells - is presynaptically expressed. by Anja Gundlfinger (366062)

“…(<b>D</b>) The mean rate of failures of synaptic transmission is decreased after expression of LTP. …”