Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors حسب Stanislav Andreev (11067165)

"…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido­[4,5-<i>b</i>]­indol-4-yl)­(methyl)­amino)­piperidin-1-yl)­propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC₅₀ value of 6 nM). …"

Protective effects of DEX on TNF-α-induced cochlear hair cells loss in cochlear explants. حسب Byung Chul Kang (1905025)

الموضوعات:

Effects of TNF-α on the cochlear hair cells in middle-turn cochlear explants. حسب Byung Chul Kang (1905025)

الموضوعات:

Attenuation of TNF-α-induced apoptosis through pretreatment of DEX in cochlear explants. حسب Byung Chul Kang (1905025)

الموضوعات:

Shooting an Arrow against Convulsion: Novel Triazole-Grafted Benzenesulfonamide Derivatives as Carbonic Anhydrase II and VII Inhibitors حسب Mohamed A. Zeidan (21099628)

"…The <i>K</i>_I values of <b>5b</b> and <b>5c</b> were 6.3 and 10.1 nM, respectively, and 21.6 and 18.9 nM, respectively. …"

Shooting an Arrow against Convulsion: Novel Triazole-Grafted Benzenesulfonamide Derivatives as Carbonic Anhydrase II and VII Inhibitors حسب Mohamed A. Zeidan (21099628)

"…The <i>K</i>_I values of <b>5b</b> and <b>5c</b> were 6.3 and 10.1 nM, respectively, and 21.6 and 18.9 nM, respectively. …"

Shooting an Arrow against Convulsion: Novel Triazole-Grafted Benzenesulfonamide Derivatives as Carbonic Anhydrase II and VII Inhibitors حسب Mohamed A. Zeidan (21099628)

"…The <i>K</i>_I values of <b>5b</b> and <b>5c</b> were 6.3 and 10.1 nM, respectively, and 21.6 and 18.9 nM, respectively. …"

Shooting an Arrow against Convulsion: Novel Triazole-Grafted Benzenesulfonamide Derivatives as Carbonic Anhydrase II and VII Inhibitors حسب Mohamed A. Zeidan (21099628)

"…The <i>K</i>_I values of <b>5b</b> and <b>5c</b> were 6.3 and 10.1 nM, respectively, and 21.6 and 18.9 nM, respectively. …"

Shooting an Arrow against Convulsion: Novel Triazole-Grafted Benzenesulfonamide Derivatives as Carbonic Anhydrase II and VII Inhibitors حسب Mohamed A. Zeidan (21099628)

"…The <i>K</i>_I values of <b>5b</b> and <b>5c</b> were 6.3 and 10.1 nM, respectively, and 21.6 and 18.9 nM, respectively. …"

Effects of DEX and TNF-α on intracellular ROS accumulation and expression of apoptosis-related proteins. حسب Byung Chul Kang (1905025)

الموضوعات:

Protective effect of DEX on cell viability, ROS generation, and expression of apoptosis-related proteins in TNF-α-treated cells. حسب Byung Chul Kang (1905025)

الموضوعات:

Attenuation of TNF-α-induced apoptosis by DEX pretreatment. حسب Byung Chul Kang (1905025)

الموضوعات:

Fig 1 - حسب Byung Chul Kang (1905025)

الموضوعات:

Data_Sheet_2_Hepcidin Decreases Rotenone-Induced α-Synuclein Accumulation via Autophagy in SH-SY5Y Cells.ZIP حسب Meiqi Li (4169182)

"…We demonstrated that SH-SY5Y cell viability was impaired after rotenone treatment in a dose-dependent manner. α-syn expression and iron content increased under a low concentration rotenone (25 nM for 3 days) treatment in SH-SY5Y cells. …"

Data_Sheet_1_Hepcidin Decreases Rotenone-Induced α-Synuclein Accumulation via Autophagy in SH-SY5Y Cells.PDF حسب Meiqi Li (4169182)

"…We demonstrated that SH-SY5Y cell viability was impaired after rotenone treatment in a dose-dependent manner. α-syn expression and iron content increased under a low concentration rotenone (25 nM for 3 days) treatment in SH-SY5Y cells. …"

HoxA9-ER directly represses <i>Cebpa</i> gene expression in myeloid cells. حسب Lei Peng (260321)

Discovery of Novel Pyrimidine-Based Capsid Assembly Modulators as Potent Anti-HBV Agents حسب WooChan Kim (10690503)

"…Moreover, treatment with compound <b>23h</b> for 5 weeks significantly decreased serum levels of HBV DNA levels (3.35 log reduction) in a human liver-chimeric uPA/SCID mouse model, and these effects were significantly increased when <b>23h</b> was combined with tenofovir, a nucleotide analogue inhibitor of reverse transcriptase used for the treatment of HBV infection.…"

Decreased hemolysis inhibition by R-P4-immunized CD1d^-/- and Traj18^-/- mice. حسب Anna Furuta (16469969)

Relative Aggrecan mRNA expression levels, as measured by qPCR, in lentiviral-transduced control cells and 5 AggKD cell lines confirm decreased Aggrecan expression in the AggKD cell... حسب Juanita K. Hodax (6848540)

ST2-104 decreases the Aβ_25-35-mediated increase in intracellular Ca²⁺. حسب Yingshi Ji (9013004)