Passive transfer of humanized anti-NS1 mAb 33D2 into DENV-inoculated mice decreases viral titer and NS1 level in mouse sera. حسب Sen-Mao Tien (12481273)

Overexpressions of the AB domain of RPA70 and the β-barrel domain of Ku70 significantly decrease HBoV1 replication in HAE-ALI. حسب Kang Ning (59789)

Impact of DNA extraction process on depth of coverage. حسب Lizhi Yu (12476136)

الموضوعات:

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... حسب Shuai Wang (109515)

"…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... حسب Shuai Wang (109515)

"…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"

Mechlorethamine gel causes epithelium thinning, epithelium-stroma separation, and decreased total stroma cell count. حسب Ana M. Sandoval-Castellanos (11611315)

"…C) The total number of cells in the stroma (yellow arrowheads in panel D) decreased after NM exposure. D) Representative images of the stroma in control and NM 5 min. …"

S5 Data - حسب Ayuta Kishimoto (16814662)

NgR1 KO mice exhibited an increase in excitatory synapses and a decrease in inhibitory synapses, indicating an imbalance of synaptic transmission. حسب Jinwei Zhang (462455)

"…The inhibitory synaptic density of NgR1 mice showed a significant decrease when compared to WT mice (***P <  0.001). …"

Cells expressing nsP2 inefficiently present antigen and have decreased levels of cell surface MHC-I. حسب Brian C. Ware (8544672)

Molecular dynamics simulations of the three systems (MMP9-MOL000098, MMP9-MOL000354, MMP9-MOL000422) after 50 ns. حسب Lefei Yu (12274846)

Molecular dynamics simulations of the three systems (IL-6-MOL000098, IL-6-MOL000354, IL-6-MOL000422) after 50 ns. حسب Lefei Yu (12274846)

Changes in cyanobacteria fluorescence with 75 μg/mL H₂O₂ for 5, 8, 17 and 24 days. حسب Emma T. Brentjens (17295999)

الموضوعات:

Machine Learning Accelerates Discovery of Optimal Colloidal Quantum Dot Synthesis حسب Oleksandr Voznyy (1376316)

الموضوعات:

Diabetic wounds show increased amounts of vessel leakage and decreased pericyte coverage. حسب Uzoagu A. Okonkwo (8754933)

Decrease in vRNA in brain during antiretroviral therapy. حسب Sonny R. Elizaldi (9684796)

oAβ enhances lysosomal acidification in NG and HG mixed glia cultures. حسب Yung-Cheng Huang (3443450)

6:2 Chlorinated Polyfluoroalkyl Ether Sulfonate (F-53B) Induces Aging and Parkinson’s Disease-like Disorders in <i>C. elegans</i> at Low Concentrations حسب Hui Li (32376)

"…After exposure to F-53B at 2, 10, and 50 ng/L, C. elegans showed an aging phenomenon as lipofuscin was significantly increased by 48.7–57.5% and locomotion, such as center point speed, was significantly decreased in all exposure groups. …"

6:2 Chlorinated Polyfluoroalkyl Ether Sulfonate (F-53B) Induces Aging and Parkinson’s Disease-like Disorders in <i>C. elegans</i> at Low Concentrations حسب Hui Li (32376)

"…After exposure to F-53B at 2, 10, and 50 ng/L, C. elegans showed an aging phenomenon as lipofuscin was significantly increased by 48.7–57.5% and locomotion, such as center point speed, was significantly decreased in all exposure groups. …"

6:2 Chlorinated Polyfluoroalkyl Ether Sulfonate (F-53B) Induces Aging and Parkinson’s Disease-like Disorders in <i>C. elegans</i> at Low Concentrations حسب Hui Li (32376)

"…After exposure to F-53B at 2, 10, and 50 ng/L, C. elegans showed an aging phenomenon as lipofuscin was significantly increased by 48.7–57.5% and locomotion, such as center point speed, was significantly decreased in all exposure groups. …"

6:2 Chlorinated Polyfluoroalkyl Ether Sulfonate (F-53B) Induces Aging and Parkinson’s Disease-like Disorders in <i>C. elegans</i> at Low Concentrations حسب Hui Li (32376)

"…After exposure to F-53B at 2, 10, and 50 ng/L, C. elegans showed an aging phenomenon as lipofuscin was significantly increased by 48.7–57.5% and locomotion, such as center point speed, was significantly decreased in all exposure groups. …"