GC-MS chromatogram of garlic essential oil. by Huda H. Elbehery (22492996)

“…The inclusion of GO-GA NPs at LC₄₀ had a significant post-effect on progeny production of <i><i>C. maculatus</i></i>, resulting in a significant reduction in the number of deposited eggs and adult emergence, which led to a significant decrease in the percentage of adult emergence to 15.23 ± 5.46 compared to 61.33 ± 2.94, as observed in the GO treatment. …”

Genes whose expression was decreased by 100 nM ouabain by more than 1.3-fold. by Larisa V. Smolyaninova (3600053)

Results isoprenaline (30nM) experiment. by L. Cao (3526226)

Firing rates of PNs (as maximum activity) in response to a single synchronous triangular pulse of 50 ms duration applied to both ORN groups. by Mario Pannunzi (553941)

Firing rates of ORNs (as maximum activity) in response to a single synchronous triangular pulse of 50 ms duration applied to both ORN groups. by Mario Pannunzi (553941)

Concentrations of particles that caused significant decreases in the viability of SNU-1 cells compared to untreated cells during 1, 2, 4, 6 or 24 h treatment periods. by Amrita Banerjee (382658)

Propagation of an action potential through ephaptic coupling is achieved for a decreased extracellular conductivity. by Karoline Horgmo Jæger (6785450)

Transcriptional and translational markers of syncytialization and biochemical differentiation are significantly decreased by rotenone. by O’Llenecia S. Walker (8486163)

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

Subjects:

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

Subjects:

Fig 5 - by Zhi Zhang (55283)

Global Land Use Change Impacts on Soil Nitrogen Availability and Environmental Losses by Jing Wang (6206297)

“…By compiling a global data set of 1,782 paired observations from 185 publications, we show that land use conversion from natural to managed ecosystems significantly reduced NNM by 7.5% (−11.5, −2.8%) and increased NN by 150% (86, 194%), indicating decreasing N availability while increasing potential N loss through denitrification and nitrate leaching. …”

SLE decreases risk for hormonal cancers. by Deborah K. Johnson (10001156)

“…(b) Prostate cancer incidence in male SLE cohort is significantly decreased by SLE status (OR 0.23, 95% CI 0.089, 0.50, p = 0.0053).…”

Idarubicin-loaded chitosan nanobubbles to improve survival and decrease drug side effects in hepatocellular carcinoma by Monica Mossenta (4276213)

Overexpressions of the AB domain of RPA70 and the β-barrel domain of Ku70 significantly decrease HBoV1 replication in HAE-ALI. by Kang Ning (59789)

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

Molecular Simulations Probing the Adsorption and Diffusion of Ammonia, Nitrogen, Hydrogen, and Their Mixtures in Bulk MFI Zeolite and MFI Nanosheets at High Temperature and Pressur... by Roshan Patel (10727011)

Subjects: