Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors حسب Stanislav Andreev (11067165)

"…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido­[4,5-<i>b</i>]­indol-4-yl)­(methyl)­amino)­piperidin-1-yl)­propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC₅₀ value of 6 nM). …"

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors حسب Stanislav Andreev (11067165)

"…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido­[4,5-<i>b</i>]­indol-4-yl)­(methyl)­amino)­piperidin-1-yl)­propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC₅₀ value of 6 nM). …"

FTY720 decreased viability, proliferation, and motility and induced apoptosis in human hepatoblastoma cells. حسب Laura L. Stafman (6577184)

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Number of patients whose HbA1c level decreased by at least 1% between baseline and 6 months. حسب Nour Ibrahim (10305490)

"…<p>Number of patients whose HbA1c level decreased by at least 1% between baseline and 6 months.…"

Excision of HIF1α decreases viral reactivation from latency in infected splenocytes in vivo. حسب Darlah M. López-Rodríguez (8098544)

ROC curve and P-R curve (attack traffic proportion = 50%). حسب Longyan Ran (18452261)

STAT6 siRNA sequences 1 and 4 significantly block STAT6 expression. حسب Carmen Salguero-Aranda (6690044)

A systematic review into the: effect of feeding food rich in cyp2a6 and glutathione enzymes on decreasing nicotine level in the body of smokers حسب Dani Nasirul Haqi (14159056)

Comparison of the decrease of CFU in CSF and blood between treatment groups within the first 6 h after treatment. حسب Luca G. Valente (12463057)

Image_3_A Shift in Myeloid Cell Phenotype via Down Regulation of Siglec-1 in Island Macrophages of Bone Marrow Is Associated With Decreased Late Erythroblasts Seen in Anemia of Cri... حسب Shirin Hasan (7894118)

"…There were more (2.5-fold) EEBs and less LEBs (2.4-fold) per million TBM cells in B; with a corresponding decrease in Siglec-1 and Ly6G expressions in EBIMØ associated with EEB. …"

Image_4_A Shift in Myeloid Cell Phenotype via Down Regulation of Siglec-1 in Island Macrophages of Bone Marrow Is Associated With Decreased Late Erythroblasts Seen in Anemia of Cri... حسب Shirin Hasan (7894118)

"…There were more (2.5-fold) EEBs and less LEBs (2.4-fold) per million TBM cells in B; with a corresponding decrease in Siglec-1 and Ly6G expressions in EBIMØ associated with EEB. …"

Digital Microfluidic Platform Based on Printed Circuit Board for Affinity Evaluation of Mertansine Aptamers حسب Dongliu Xiang (10688647)

الموضوعات:

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... حسب Shuai Wang (109515)

"…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... حسب Shuai Wang (109515)

"…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"

The relative abundance of individual cellular mRNAs in the cytoplasm and on polysomes decreases between 2 and 6 hpi. حسب William J. Neidermyer Jr. (6866672)

Repeated LSPC treatment prolongs survival of and decreases PrP^Res accumulation in a subset of prion-infected mice. حسب Heather Bender (363996)

Number of samples per site during the study period. حسب Winnie Okore (14139712)

الموضوعات:

Performance of selected antimalarials against field isolates during the study period. حسب Winnie Okore (14139712)

الموضوعات:

<i>Pfmrp1</i> gene SNPs data during the study period. حسب Winnie Okore (14139712)

الموضوعات:

Performance of selected drugs against field isolates during the study period. حسب Winnie Okore (14139712)

الموضوعات: