Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

HSP90 inhibition by RGRN-305 decreased the gene expression of proinflammatory cytokines induced by SARS-CoV-2 S protein. by Hakim Ben Abdallah (14578241)

Absorption spectra of 12.5 mM sodium chlorite solutions with different concentrations of sulfuric acid. by Ayuta Kishimoto (16814662)

S10 Fig - by Jordan K. Abbott (8934239)

Fibrin concentration of 10,000 simulations compared to experimental data of blood clotting over collagen/ TF under venous flow rate. by Jason Chen (15937)

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Reference mutations versus background noise across replicates. by Lizhi Yu (12476136)

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Quantification and accuracy of average VAF. by Lizhi Yu (12476136)

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Analytical sensitivity and reproducibility. by Lizhi Yu (12476136)

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Depth of coverage and heterogeneity of the mutation loci. x-axis, mutation loci in sample set one or two; y-axis, depth of coverage after UMI consolidation. by Lizhi Yu (12476136)

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Impact of mutation type on VAF quantification performance. by Lizhi Yu (12476136)

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Schematic overview of the cross-platform study. by Lizhi Yu (12476136)

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Impact of DNA extraction process on depth of coverage. by Lizhi Yu (12476136)

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CRISPR-Cas9 knockout of <i>CLU</i> results in decreased VWF protein expression VWF mRNA. by Allaura A. Cox (17980027)

Measurement of mitochondrial superoxide anion production in HL-1 cells exposed for 12 or 72h to LG, NG, HG or IHG. by Patrick Mordel (17020879)

Transient convection-diffusion of thrombin into and out of a fibrin domain exposed to venous flow. by Jason Chen (15937)

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Internalized oAβ puncta colocalize with lysosomes in NG and HG mixed glia cultures. by Yung-Cheng Huang (3443450)

Confocal images of oAβ internalization by astrocytes in NG and HG mixed glia cultures. by Yung-Cheng Huang (3443450)

Leg and wing <i>IR52a</i>^<i>+</i> neurons form functional connections with neurons in the SEZ. by Zhe He (508742)

Image_1_Decreased Serum Brain-Derived Neurotrophic Factor in Poststroke Depression: A Systematic Review and Meta-Analysis.pdf by Chunhui Zhang (337556)

Image_2_Decreased Serum Brain-Derived Neurotrophic Factor in Poststroke Depression: A Systematic Review and Meta-Analysis.pdf by Chunhui Zhang (337556)