Showing 221 - 240 results of 64,738 for search '(( 5 nm decrease ) OR ( 5 ((((point decrease) OR (fold decrease))) OR (a decrease)) ))', query time: 0.95s Refine Results
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    Structure-Based Design of a Chemical Probe Set for the 5‑HT<sub>5A</sub> Serotonin Receptor by Anat Levit Kaplan (12126567)

    Published 2022
    “…Docking over 6 million molecules against a 5-HT<sub>5A</sub>R homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT<sub>5A</sub>R with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”
  7. 227

    Structure-Based Design of a Chemical Probe Set for the 5‑HT<sub>5A</sub> Serotonin Receptor by Anat Levit Kaplan (12126567)

    Published 2022
    “…Docking over 6 million molecules against a 5-HT<sub>5A</sub>R homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT<sub>5A</sub>R with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”
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    Mean decrease in accuracy (MDA) of top 15 urine metabolites. by Liam E. Broughton-Neiswanger (8447220)

    Published 2020
    “…Urine metabolites with a mean decrease in accuracy ≥ 0.004 in at least one post-treatment time point (2–5) were considered for inclusion in the predictive model.…”
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