Bortezomib in combination with the PLK1 inhibitor BI 2536 induces a significant downregulation of the total levels and phosphorylation of Bcr-Abl, a decrease of downstream phosphorylated STAT5 and a caspase-dependent cell death in TKIs-resistant and –sensitive K562 cell lines. by Octavian Bucur (470431)

“…The combined treatment resulted in a marked decrease of the total levels of Bcr-Abl, which correlates with a decrease in the phosphorylation of the downstream STAT5 protein, in both K562 and K562-R cells. β-Actin was used as an internal loading control. …”

C1INH significantly decreased renal C5a cleavage and limited C3b deposition in kidneys subjected to IRI. by Juan S. Danobeitia (4386205)

Aspirin-Triggered Resolvin D1 does not rescue barrier function in IL-1β-treated A549 cells. by Ruan Cox Jr. (789575)

CDK5 knockdown increases TP53 and p27^Kip1 protein half-lives, increases nuclear localization of the two proteins, decreases p27^Kip1 p-T187 phosphorylation and induces p21^Cip1 in a TP53-dependent manner. by Shu Zhang (22238)

“…<p>(<b>A</b>) Transfection with CDK5 siRNA increased the half-life of p53 and p27^Kip1 protein. …”

EtOH decreased ΔΨm in a subset of esophageal keratinocytes. by Prasanna M. Chandramouleeswaran (3176268)

Blocking of MC1R, MC2R or MC5R causes a decrease in the enucleation ratio of erythrocytes. by Eriko Simamura (720229)

“…The enucleation ratio was decreased in the erythroblasts treated with anti-MC1R nAb, anti-MC2R nAb or anti-MC5R nAb. *, <i>P <</i> 0.0001, each point versus control. n = 3; error bars, s.e.m. …”

rVλ6Wil fibrils cause a decrease in cardiomyocytes MTT reduction without inducing cell death. by Helen P. McWilliams-Koeppen (116503)

“…(C) Cell number, quantified using crystal violet (black) did not decrease over 72 h of incubation with 1 μM rVλ6Wil fibrils despite a decrease in MMT reduction (grey; n = 3 samples per time point). …”

TGF-β1 had little effect on MMP-2, MMP-3 and MMP-14 expression, but decreased expression of MMP-16. by Youssef M. Farhat (295089)

Manganase²⁺ stimulation decreases association of ADAM17 to β1 integrin and leads to increased ADAM17 activity. by Pal Gooz (330154)

(R+S) and (R)-albuterol decrease NF-κB activity by Marcela A Ferrada (41716)

“…After transfection, (R)-albuterol (R), (S)-albuterol (S), or racemic albuterol (R+ S) were added to cells pre-activated with (ConA, 5 μg/ml) and (PMA, 100 ng/ml) (CP) and then treated with (R)-, (S)-, or (R+S)-albuterol (Fig. 6). …”

Removal of the A-B linker did not decrease PIP₂ affinity. <i>A.-</i> by Paloma Aivar (124885)

Inhibition of the mitochondrial fission decreases mtROS production. by Dong Ma (584680)

Subjects:

Nicotine decreased Akt phosphorylation in SK-BR-3 cells. by Masanori A. Murayama (5774585)

Table_1_When and Why Did Human Brains Decrease in Size? A New Change-Point Analysis and Insights From Brain Evolution in Ants.XLSX by Jeremy M. DeSilva (7247009)

“…<p>Human brain size nearly quadrupled in the six million years since Homo last shared a common ancestor with chimpanzees, but human brains are thought to have decreased in volume since the end of the last Ice Age. …”

Estimates of the phenotypic mean, environmental variance (<i>V</i>_<i>E</i>), additive genetic variance (<i>V</i>_<i>A</i>), and heritability (<i>h</i><sup><i>2... by Ryan M. Imrie (15810854)

Subjects:

Fold change in humoral and cellular response magnitudes from RV305 week 2 to week 26. by LaTonya D. Williams (3140490)

VEGFR2/VEGF-A ligand binding decreased ranibizumab and aflibercept mediated CCL2, CCL5, and CX3CL1 mRNA and protein levels in HCAECs. by Clare Arnott (2557705)

Homozygous deletion of <i>ERG251</i> results in decreased fitness at low initial cell density and increased fitness in the presence of low concentrations of FLC (≤1μg/ml). by Xin Zhou (54275)

HVR1-swap compensatory E1/E2 substitutions typically decrease virus entry dependency on SR-BI. by Christina Holmboe Olesen (11154333)

Dexamethasone decreases PGC-1α protein expression and transcription. by Jill A. Rahnert (2872766)

“…<p>(A) Treatment of L6 myotubes with Dex (100nM, 48hrs) decreased PGC-1α protein expression (p = 0.01). n = 3/treatment from 3 experiments. …”