Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

B2 decreases glycolytic intermediates in cells. by Craig Eyster (392633)

“…<b>(C)</b> Heatmap of targeted metabolomic data. Each column is a separate biological replicate (n = 5). The box indicates the clustering of decreased downstream glycolytic intermediates in B2-treated cells. …”

Reduced expression of Tks5 leads to decreased growth of tumor cells <i>in vitro</i> and <i>in vivo</i>. by Barbara Blouw (715467)

Laquinimod prevents EAE and decreases encephalitogenicity of T cells. by Ulf Schulze-Topphoff (174453)

“…Representative FACS staining is shown including quantification (n = 4–5 mice per group). (E) Laquinimod decreases pathogenic potential of T cells. …”

Dopamine decreases the refractive power in the lens periphery. by J. Marcus Schartau (365288)

“…<p>(A) The mean ΔBCD curves describe the difference between the treated and untreated lenses from all animals (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010402#s4" target="_blank">Methods and Materials</a>). …”

Fucoidan decreased lung metastases of breast cancer. by Meilan Xue (310911)

Erlotinib decreases hypoxia <i>in vivo</i>. by George J. Cerniglia (261405)

Klotho decreased the expression of CHOP in mouse heart. by Shuang Song (457799)

Mice exposed to neonatal hyperoxia have persistent RVH and decreased vessel density at 21d. by Marta Perez (526067)

BRCA1 silencing decreases cell viability. by Pei Chen (252989)

Madrasin decreases transcription of protein-coding genes. by Michael Tellier (8284752)

TG6-44 treatment decreases A/X31-induced ROS in THP-1 cells. by Juan A. De La Cruz (11154187)

Decreased focus score in early treated mice. by Nienke Roescher (159484)

Decreased function of Nrf2 in the aging heart. by Sellamuthu S. Gounder (306106)

“…<p>(<b>A</b>) <b>Decreased nuclear translocation of Nrf2 is evident in the heart of aging mice.…”

Maximum IFN concentrations are decreased in severe patients. by Sonia T. Gazeau (21512764)

Vi expression decreases antibody and complement binding to <i>Salmonella</i> in the absence of specific antibodies. by Peter J. Hart (503558)

MBCD decreased stemness in MDA-MB-231. by Ankit Sharma (578833)

“…<p>(<b>A</b>) Colony formation assay was performed. MDA-MB-231 cells were plated at low density (1000 cells/well) in 6 well plates. …”

Concept-pair promiscuity decreases as score increases. by Susan Khor (524773)

PG treatment decreases HCC cell survival. by Po-Li Wei (292225)

Madrasin decreases transcription of protein-coding genes. by Michael Tellier (8284752)