Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Tranilast decreases RANKL-induced ROS level. by Tien Van Phan (583324)

<i>neurod1</i>^<i>ΔUCE</i> homozygous mutants display a decrease in the expression of several EE hormones. by Anne Sophie Reuter (12239993)

LP I_h metamodulation is rapid and reversible. by Wulf-Dieter C. Krenz (693267)

“…<p><b>(A) The time course for metamodulation in 5nM DA</b>. …”

A low dose of BTZ decreases proteasome activity with no effect on cell viability. by A. L. Furfaro (2587792)

NSAIDs decrease the viability of ovarian cancer cells in a dose-dependent manner. by Blanca L. Valle (406582)

Deletion of SWI/SNF results in decreased recruitment of Cdc28 (PRP2) and retention of Cwf24 (CWC24). by Kristin L. Patrick (715340)

(A) FACS analysis of cell surface markers on untreated or 5 nM Bortezomib treated mature dendritic cells. by Daniela Grabher (383863)

“…<p>Maturation marker expression (CD80, CD83 and CD86, MHC class I and MHC class II) on mature dendritic cells and mature dendritic cells treated with 5 nM Bortezomib were measured. Maturation markers show no difference when treated with 5 nM Bortezomib. …”

PTH decreased cell apoptosis in a Flt-3L expanded population. by Flavia Q. Pirih (360515)

(A) Shape of the osteotomies during the 3-step MIPS drilling procedure. by Marsel Ganeyev (21453399)

5-HT supplementation induces mitochondrial damage. by Li Gao (131516)

Algorithm operation steps. by Junyan Wang (4738518)

“…Experimental results demonstrate that SCI-YOLO11 achieves a 3.2% improvement over baseline models in terms of MAP@0.5 metric; precision and recall rates increase by 2.6% and 3.7%, respectively. …”

Biologic activity of LY5 in sarcoma cell lines. by Peter Y. Yu (4281448)

Supplementary Videos (File S3) show a step-by-step protocol for preparing and connecting <i>Apis mellifera</i> workers to the electrical measurement system. by Juan P. Hernández (22216133)

AEA decreases mPGES-1 mRNA and protein levels. by Claudia A. Vercelli (284964)

Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

Increased reactive oxygen species (ROS) production and decreased mitochondrial membrane potential in <i>Tet-mev-1</i> hepatocytes. by Tadashi Moro (844328)

<i>neurod1</i>^<i>ΔUCE</i> homozygous mutants display an increase of the goblet cells concomitant with a decrease of EECs. by Anne Sophie Reuter (12239993)

The image illustrates the five steps of the experiment. by Deborah Ribeiro Frazão (9188152)