Showing 121 - 140 results of 17,556 for search '(( 5 nm decrease ) OR ( 50 ((((nn decrease) OR (teer decrease))) OR (a decrease)) ))', query time: 0.49s Refine Results
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    Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

    Published 2021
    “…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido­[4,5-<i>b</i>]­indol-4-yl)­(methyl)­amino)­piperidin-1-yl)­propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC<sub>50</sub> value of 6 nM). …”
  3. 123

    Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

    Published 2021
    “…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido­[4,5-<i>b</i>]­indol-4-yl)­(methyl)­amino)­piperidin-1-yl)­propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC<sub>50</sub> value of 6 nM). …”
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    FTY720 decreased viability, proliferation, and motility and induced apoptosis in human hepatoblastoma cells. by Laura L. Stafman (6577184)

    Published 2019
    “…<p>(A) Following 24 hours of treatment with FTY720, the viability of HuH6 cells measured using the alamarBlue cell viability assay was significantly decreased (LD<sub>50</sub> = 8.4 μM, p ≤ 0.05). …”
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    Shooting an Arrow against Convulsion: Novel Triazole-Grafted Benzenesulfonamide Derivatives as Carbonic Anhydrase II and VII Inhibitors by Mohamed A. Zeidan (21099628)

    Published 2025
    “…The <i>K</i><sub>I</sub> values of <b>5b</b> and <b>5c</b> were 6.3 and 10.1 nM, respectively, and 21.6 and 18.9 nM, respectively. …”
  19. 139

    Shooting an Arrow against Convulsion: Novel Triazole-Grafted Benzenesulfonamide Derivatives as Carbonic Anhydrase II and VII Inhibitors by Mohamed A. Zeidan (21099628)

    Published 2025
    “…The <i>K</i><sub>I</sub> values of <b>5b</b> and <b>5c</b> were 6.3 and 10.1 nM, respectively, and 21.6 and 18.9 nM, respectively. …”
  20. 140

    Shooting an Arrow against Convulsion: Novel Triazole-Grafted Benzenesulfonamide Derivatives as Carbonic Anhydrase II and VII Inhibitors by Mohamed A. Zeidan (21099628)

    Published 2025
    “…The <i>K</i><sub>I</sub> values of <b>5b</b> and <b>5c</b> were 6.3 and 10.1 nM, respectively, and 21.6 and 18.9 nM, respectively. …”