Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... حسب Shuai Wang (109515)

"…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"

HAstV-8 (D471S, N512D) spike has decreased or no binding to FcRn compared to wild-type HAstV-8 spike. حسب Catalina Aguilera-Flores (21743843)

HEWL interacts with dissipated oleic acid micelles, and decreases oleic acid cytotoxicity - Fig 1 حسب Qin Huang (49441)

Silencing <i>cullin-1/5</i> decreased mRNA and protein expression of NF-κB dependent cytokines. حسب Attinder Chadha (11414273)

Molecular Simulations Probing the Adsorption and Diffusion of Ammonia, Nitrogen, Hydrogen, and Their Mixtures in Bulk MFI Zeolite and MFI Nanosheets at High Temperature and Pressur... حسب Roshan Patel (10727011)

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Dysregulated alternative splicing in DM1 hiNeurons at 10 DPI. حسب Mougina K. Eltahir (12988153)

Thermodynamic parameters of CR adsorbed onto magnetic Co_0.5Mn_0.5Fe₂O₄ nanoparticles. حسب Xiajun Zhang (3161865)

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Structure–Activity Relationship of 3‑Methylcytidine-5′-α,β-methylenediphosphates as CD73 Inhibitors حسب Mirko Scortichini (4007366)

"…We now expand the structure–activity relationship of pyrimidine nucleotides as human CD73 inhibitors. 4-Chloro (MRS4598 <b>16</b>; <i>K</i>_i = 0.673 nM) and 4-iodo (MRS4620 <b>18</b>; <i>K</i>_i = 0.436 nM) substitution of the <i>N</i>⁴-benzyloxy group decreased <i>K</i>_i by ∼20-fold. …"

Structure–Activity Relationship of 3‑Methylcytidine-5′-α,β-methylenediphosphates as CD73 Inhibitors حسب Mirko Scortichini (4007366)

"…We now expand the structure–activity relationship of pyrimidine nucleotides as human CD73 inhibitors. 4-Chloro (MRS4598 <b>16</b>; <i>K</i>_i = 0.673 nM) and 4-iodo (MRS4620 <b>18</b>; <i>K</i>_i = 0.436 nM) substitution of the <i>N</i>⁴-benzyloxy group decreased <i>K</i>_i by ∼20-fold. …"

Structure–Activity Relationship of 3‑Methylcytidine-5′-α,β-methylenediphosphates as CD73 Inhibitors حسب Mirko Scortichini (4007366)

"…We now expand the structure–activity relationship of pyrimidine nucleotides as human CD73 inhibitors. 4-Chloro (MRS4598 <b>16</b>; <i>K</i>_i = 0.673 nM) and 4-iodo (MRS4620 <b>18</b>; <i>K</i>_i = 0.436 nM) substitution of the <i>N</i>⁴-benzyloxy group decreased <i>K</i>_i by ∼20-fold. …"

Data_Sheet_1_Secondhand Smoke Decreased Excitability and Altered Action Potential Characteristics of Cardiac Vagal Neurons in Mice.PDF حسب Junqing Sun (4688998)

"…Perfusion with apamin (20 nM) magnified these SHS-induced effects, suggesting reduced SK channel activity may serve to minimize the SHS-induced decreases in CVNs excitability. …"

Time series of macrofaunal crustacean abundance at stations in DBO regions 2–5 over the 2010–2019 period. حسب Sue E. Moore (2932644)

Compared the maximum adsorption capacity of CR onto magnetic Co_0.5Mn_0.5Fe₂O₄ nanoparticles with other adsorbents. حسب Xiajun Zhang (3161865)

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ABT199 inhibits ALK ^mutant kinase activity and decreases it phosphorylation. حسب Richard Junior Zapata Dongo (17912565)

Disjoining Pressure of Water in Nanochannels حسب An Zou (781227)

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Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet حسب Soonho Kwon (1402972)

الموضوعات:

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet حسب Soonho Kwon (1402972)

الموضوعات:

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet حسب Soonho Kwon (1402972)

الموضوعات:

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet حسب Soonho Kwon (1402972)

الموضوعات:

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet حسب Soonho Kwon (1402972)

الموضوعات: