Showing 121 - 140 results of 7,354 for search '(( 5 nn decrease ) OR ((( 50 ms decrease ) OR ( 50 ((ng decrease) OR (we decrease)) ))))', query time: 0.42s Refine Results
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    Analysis of NIST Monoclonal Antibody Reference Material Glycosylation Using the LC–MS/MS-Based Glycoproteomic Approach by Jingfu Zhao (3113421)

    Published 2020
    “…Glycosylation is an essential critical quality attribute (CQA) due to the influence that glycoforms have on the safety, efficacy, and pharmacokinetics/pharmacodynamics (PK/PD) of biotherapeutics. Here, we applied an LC–MS/MS-based glycoproteomics approach to characterize Fc glycans of an NISTmAb reference material (RM) 8671 (sample B) and a β-1,4-galactosidase-treated NISTmAb (sample A). …”
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    First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

    Published 2022
    “…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC<sub>50</sub> value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC<sub>0‑inf</sub> (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”
  12. 132

    First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

    Published 2022
    “…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC<sub>50</sub> value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC<sub>0‑inf</sub> (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”
  13. 133

    Flow chart of the study procedures. by Kazuhiko Ikeuchi (9234268)

    Published 2023
    “…Pre-treatment spontaneous decrease of RPR titer was associated with a slower decrease in post-treatment RPR titer.…”
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    Interplay Between Applied Force and Radical Attack in the Mechanochemical Chain Scission of Poly(acrylic acid) by Michael T. Robo (1342344)

    Published 2022
    “…The force needed for bond rupture was estimated to decrease from 4.7 to 2.5 nN. This occurs because hydrogen atom abstraction drastically alters the potential energy surface of the scissile bond. …”
  17. 137

    Interplay Between Applied Force and Radical Attack in the Mechanochemical Chain Scission of Poly(acrylic acid) by Michael T. Robo (1342344)

    Published 2022
    “…The force needed for bond rupture was estimated to decrease from 4.7 to 2.5 nN. This occurs because hydrogen atom abstraction drastically alters the potential energy surface of the scissile bond. …”
  18. 138

    Interplay Between Applied Force and Radical Attack in the Mechanochemical Chain Scission of Poly(acrylic acid) by Michael T. Robo (1342344)

    Published 2022
    “…The force needed for bond rupture was estimated to decrease from 4.7 to 2.5 nN. This occurs because hydrogen atom abstraction drastically alters the potential energy surface of the scissile bond. …”
  19. 139

    Interplay Between Applied Force and Radical Attack in the Mechanochemical Chain Scission of Poly(acrylic acid) by Michael T. Robo (1342344)

    Published 2022
    “…The force needed for bond rupture was estimated to decrease from 4.7 to 2.5 nN. This occurs because hydrogen atom abstraction drastically alters the potential energy surface of the scissile bond. …”
  20. 140

    Interplay Between Applied Force and Radical Attack in the Mechanochemical Chain Scission of Poly(acrylic acid) by Michael T. Robo (1342344)

    Published 2022
    “…The force needed for bond rupture was estimated to decrease from 4.7 to 2.5 nN. This occurs because hydrogen atom abstraction drastically alters the potential energy surface of the scissile bond. …”