Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Ariadne emerges as a prototype of a new drug class, non-hallucinogenic 5-HT_2A agonists, with considerable therapeutic potential across psychiatric and neurological indications.…”

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Ariadne emerges as a prototype of a new drug class, non-hallucinogenic 5-HT_2A agonists, with considerable therapeutic potential across psychiatric and neurological indications.…”

The coefficient of variation of the neural activity, unlike that of velocity, was decreased in animals pre-exposed to 5-HT and <i>mod-1</i> mutants. by Haruka Mori (8082215)

Downregulation of DOM decreases the abundance of PER and TIM. by Zhenxing Liu (399809)

“…Downregulation of DOM decreased PER levels at CT1-5 and CT17-21. (Scale bar: 50 um.) …”

Changes in neural activity were decreased in animals pre-exposed to 5-HT and <i>mod-1</i> mutants when the worms switched their locomotive direction. by Haruka Mori (8082215)

“…<p>(A–F) the neural activity of the RID changes during the transition periods from backward to forward locomotion (A–C) and from forward to backward locomotion (D–F) in the mock (A: p = 1.5 × 10⁻⁵; D: p = 5.5 × 10⁻¹³), 5-HT exposed (B: p = 0.092; E: p = 0.79), and <i>mod-1</i> mutant (C: p = 0.081; F: p = 0.93) groups. …”

Impaired Ubr5 function results in increased canonical and decreased non-canonical HH signalling. by David Mellis (2833469)

Crosslinking decreases the alignment of fibers associated with individual cells migrating out of spheroids. by Michael Pamonag (12295175)

The influence of 5-HT in mice serum on <i>Plasmodium</i> infection in mosquitoes. by Li Gao (131516)

5-HT inhibits <i>P</i>. <i>berghei</i> infection in mosquitoes. by Li Gao (131516)

“…The purple boxes represent the metabolites of the indole pathway, the blue boxes represent the metabolites of the 5-HT pathway, and the tan boxes represent the metabolites of the kynurenine pathway. …”

Table_1_FMT intervention decreases urine 5-HIAA levels: a randomized double-blind controlled study.DOCX by Lihong Wang (14991)

“…However, in the placebo group, GSRS, CARS, and SRS scores showed no significant changes, while ABC scores decreased from 72 to 58.75 (p = 0.034). The FMT group also showed a significant reduction in urinary 5-hydroxyindoleacetic acid (5-HIAA) levels from 8.6 to 7.32 mg/L (p = 0.022), while other metabolites showed no significant changes.…”

Example of K^trans decrease during therapy. by Jean-Philip Daniel Weber (12213395)

Effect of 5-HT depletion via pCPA on incentive. by Yukiko Hori (299784)

Subjects:

Decrease in ISV diameter exacerbates the decrease in WSS caused by hematocrit reduction. by Swe Soe Maung Ye (12895103)

ROS and superoxide decrease in the dormant form of mycobacteria. by Amar Yeware (7115063)

5-HT supplementation inhibits mitophagy. by Li Gao (131516)

Matrix crosslinking decreases cell migration persistence. by Michael Pamonag (12295175)

Nimodipine does not decrease markers of neuritic dystrophy in 5XFAD transgenic mice. by Katherine R. Sadleir (12035242)

Subjects:

Cumulative effects and geographic distribution of mCHG-decreasing alleles. by Eriko Sasaki (501178)

“…Filled circles indicate mCHH- or mCHG-decreasing alleles. Mapping and statistical testing were performed in R version 3.5.3. …”

5-HT supplementation induces mitochondrial damage. by Li Gao (131516)

The influence of 5-HT on MSQ43 cells. by Li Gao (131516)