Discovery of New Inhibitors of Hepatitis C Virus NS3/4A Protease and Its D168A Mutant by Ittipat Meewan (7455041)

“…Several drugs targeting the protease have been developed, but drug-resistant mutant strains emerged. Here, we screened a library and synthesized a novel class of small molecules based on a tryptophan derivative scaffold identified as HCV NS3/4A protease inhibitors that are active against both wild type and mutant form of the protease. …”

Image_1_Reduced Ca2+ transient amplitudes may signify increased or decreased depolarization depending on the neuromodulatory signaling pathway.PDF by Arunima Debnath (13136676)

“…We are investigating the polymodal nociceptor ASH in Caenorhabditis elegans to better understand the relationship between neuronal excitability and optically recorded Ca²⁺ transients. …”

<b>When more isn’t better: Sperm competition decreases fertilization success and motile sperm in two sea urchin species</b> by Luisa Kumpitsch (20874095)

“…<p dir="ltr">Abstract of the paper "<b>When more isn’t better: Sperm competition decreases fertilization success and motile sperm in two sea urchin species":</b></p><p dir="ltr">Fertilization is a fundamental process where sperm-egg fusion is essential to maintain life of most metazoans. …”

Variable importance plot (mean decrease accuracy and mean decrease Gini). by Fernando Martinez-Taboada (8655132)

Excel file of Raw Data for Figures 2–5. by Daniel R. Ambruso (12042605)

“…Stimulated release of superoxide anion (O₂^-) was minimally changed. Treatment decreased expression of 483 genes and increased 386. …”

Image1_Decreased mitochondrial respiration associates with frailty in community-dwelling older adults.jpg by Gianella Liabeuf (18512634)

“…The mean age of the participants was 80.2 ± 5.2 years, similar in both groups of men and women. …”

miR-200c decreases KLOTHO expression in HK-2 cells by translational repression. by Kenichi Morii (6843554)

Competition localization increases with growth rate or the distances between colonies, and decreases with the resource diffusion constant. by Jeremy M. Chacón (8259792)

Abolishing the ordered neuron density gradient decreased the positive correlation observed for axon elongation scaling. by Sarah F. Beul (6008801)

Table1_Discontinuation of afterload-reducing drugs decreases left ventricular outflow tract obstruction in hypertrophic obstructive cardiomyopathy.docx by Anselm A. Derda (5866220)

“…</p>Results<p>16 patients discontinued their afterload-reducing drugs, resulting in a significant decrease in median LVOT gradient from 86.5 [60.5–109.3] mmHg to 61.5 [28.3–97.50] mmHg (p = 0.0004). …”

Table1_Discontinuation of afterload-reducing drugs decreases left ventricular outflow tract obstruction in hypertrophic obstructive cardiomyopathy.docx by Anselm A. Derda (5866220)

“…</p>Results<p>16 patients discontinued their afterload-reducing drugs, resulting in a significant decrease in median LVOT gradient from 86.5 [60.5–109.3] mmHg to 61.5 [28.3–97.50] mmHg (p = 0.0004). …”

Data_Sheet_1_Improved body composition decreases the fat content in non-alcoholic fatty liver disease, a meta-analysis and systematic review of longitudinal studies.docx by Dóra Mátis (15407060)

“…Eligible studies reported on patients with NAFLD (liver fat >5%) and examined the correlation between body composition improvement and decrease in steatosis. …”

S2 File - by Alejandro Valencia (16007329)

Subjects:

Trial profile. by Chanel Avenant (409756)

“…Both contraceptives substantially decreased, from D0 to 25W, the total testosterone [DMPA-IM D0 0.560, 25W 0.423 nmol/L, -24.3% (p < 0.0001); NET-EN D0 0.551, 25W 0.253 nmol/L, -54.1%, (p < 0.0001)], SHBG [DMPA-IM D0 45.0, 25W 32.7 nmol/L, -29.8% (p < 0.0001); NET-EN D0 50.2, 25W 17.6 nmol/L, -65.1% (p < 0.0001)], and calculated free testosterone levels [DMPA-IM D0 6.87, 25W 5.38 pmol/L, -17.2% (p = 0.0371); NET-EN D0 6.00, 25W 3.70, -40.0% (p < 0.0001)]. …”

Annual treatment frequencies in recurrence and non-recurrence groups. by Yasuyuki Sotani (20114144)

“…Mean outpatient visits in the recurrence group decreased from 13.6 ± 3.0 to 11.9 ± 5.0, 8.1 ± 3.9, and 7.8 ± 3.2 at 1, 2, and 3 years postoperatively, respectively (Kruskal-Wallis test, p < 0.001). …”

E₅₀ values of angle. by Junxia Zhou (14381598)

“…The research results indicate that: (1) As the rock bridge angle increases, the secant modulus gradually decreases, following a power function relationship. (2) As the rock size increases, the secant modulus shows a trend of first decreasing and then stabilizing, following a power function relationship. (3) As the rock bridge angle increases, the characteristic tangent modulus and characteristic size gradually decrease, following a power function relationship. …”

Curve fitting of E₅₀. by Junxia Zhou (14381598)

“…The research results indicate that: (1) As the rock bridge angle increases, the secant modulus gradually decreases, following a power function relationship. (2) As the rock size increases, the secant modulus shows a trend of first decreasing and then stabilizing, following a power function relationship. (3) As the rock bridge angle increases, the characteristic tangent modulus and characteristic size gradually decrease, following a power function relationship. …”

Fitting curves of E₅₀. by Junxia Zhou (14381598)

“…The research results indicate that: (1) As the rock bridge angle increases, the secant modulus gradually decreases, following a power function relationship. (2) As the rock size increases, the secant modulus shows a trend of first decreasing and then stabilizing, following a power function relationship. (3) As the rock bridge angle increases, the characteristic tangent modulus and characteristic size gradually decrease, following a power function relationship. …”

E₅₀ values of size. by Junxia Zhou (14381598)

“…The research results indicate that: (1) As the rock bridge angle increases, the secant modulus gradually decreases, following a power function relationship. (2) As the rock size increases, the secant modulus shows a trend of first decreasing and then stabilizing, following a power function relationship. (3) As the rock bridge angle increases, the characteristic tangent modulus and characteristic size gradually decrease, following a power function relationship. …”

E₅₀ fluctuation coefficient. by Junxia Zhou (14381598)

“…The research results indicate that: (1) As the rock bridge angle increases, the secant modulus gradually decreases, following a power function relationship. (2) As the rock size increases, the secant modulus shows a trend of first decreasing and then stabilizing, following a power function relationship. (3) As the rock bridge angle increases, the characteristic tangent modulus and characteristic size gradually decrease, following a power function relationship. …”