Inhibition of Glioblastoma Growth by the Thiadiazolidinone Compound TDZD-8 by Diana Aguilar-Morante (237970)

“…<div><h3>Background</h3><p>Thiadiazolidinones (TDZD) are small heterocyclic compounds first described as non-ATP competitive inhibitors of glycogen synthase kinase 3β (GSK-3β). …”

Citral effect in male NMRI mice nonalcoholic steatosis model: assessing biochemical and histological parameters and PPARα gene expression by Maryam Vaezi (6045914)

“…Here, the effect of intraperitoneal (IP) administration of citral is evaluated in a mouse model of non-alcoholic steatosis. Male NMRI mice were divided into the following groups (n = 12): normal control group (NC) receiving a normal diet; high-fat emulsion group (HF) receiving high fat diet for four weeks; positive control group (C+) receiving HF diet for four weeks and then shifted to normal diet with IP-administered silymarin (80 mg/kg) for four weeks; sham group receiving HF diet for four weeks and then shifted to normal diet for four weeks; and EC1, EC2, and EC3 groups receiving HF diet for four weeks and then shifted to normal diet with IP-administered citral doses of 5, 10, and 20 mg/kg, respectively. …”

Preferential Interactions and the Effect of Protein PEGylation by Louise Stenstrup Holm (778109)

“…It was found that PEGylated lysozyme was stabilized by the preferentially excluded excipient and destabilized by the preferentially bound excipient in a similar manner as lysozyme. However, compared to lysozyme in all cases the melting transition was lower by up to a few degrees and the calorimetric melting enthalpy was decreased to half the value for PEGylated lysozyme. …”

Sensitivity (black) and false positive rate (gray) for analyses on simulated datasets. by Rolf J. F. Ypma (438109)

“…<p>For each of nine simulation scenarios, percentage of outbreak (black) and non-outbreak (gray) cases assigned to a putative transmission cluster are shown. …”

Group differences in the time course of Blood Oxygen Level-Dependent (BOLD) responses over the entire course of the pain experience. by Imanuel Lerman (6331049)

“…Treatment with nVNS significantly decreased the response of the postcentral gyrus during and after the application of noxious thermal stimuli (5 seconds each), up to 12 seconds after cessation of the painful stimulus. …”

Medical care costs of cancer in the last year of life using national health insurance data in Korea by Mihai Park (5349077)

“…The mean monthly inpatient costs for AML increased from $5,465 (SD, $5,248) in 12 months prior to death to $15,033 (SD, $11,864) in the last month. …”

Regulatory snapshots of documented regulators in yeast heat shock modules. by Joana P. Gonçalves (118977)

“…Each snapshot along a row was obtained for a particular time point. …”

Regulatory snapshots of regulators with large relevance variations in yeast heat shock modules. by Joana P. Gonçalves (118977)

“…In every row, each figure highlights the relevance of a particular regulator placed among the 30 best ranked TFs for a specific time point. …”

DataSheet1_Molecular Genetic Screening in Patients With ACE Inhibitor/Angiotensin Receptor Blocker-Induced Angioedema to Explore the Role of Hereditary Angioedema Genes.docx by Carina M. Mathey (13109175)

“…In addition, rare, potentially functional variants (MAF < 5%, Phred-scaled combined annotation dependent depletion score >10) showed a nominally significant enrichment in controls both: 1) across all five genes; and 2) in the F12 gene alone. …”

Table 1_The kinetic behavior of matrine in pig intestinal lumen after oral administration and its physiologically based pharmacokinetic modeling.docx by Bo Yang (104813)

“…The concentration-time data were analysed by non-compartmental method. Subsequently, a four-compartment PBPK model was developed and validated.…”

Intracellular probe binding and identification of cytosolic tryparedoxin peroxidase as protein target. by Douglas O. Escrivani (9746505)

“…<p>(<b>A</b>) Confocal microscopy of <i>L</i>. <i>amazonensis</i> promastigotes treated (a5-a8) or not (a1-a4) with <b>2</b> (5 uM) for 5 h prior to labelling with red fluorescent probe <b>4</b> (5uM) by CuAAC. …”

<i>SEL1L</i> variants affect proteasome inhibition sensitivity. by Travis K. Tu’ifua (22008843)

“…<b>(B)</b> When treated with 1μM BTZ, the <i>NGLY1 + /-</i> larvae show a <i>SEL1L</i> genotype-dependent decrease in size. …”

Ala⁴⁸²-Ser⁴⁸³ was the key peptide bond that allowed the PP-RGD domain to become inactive. by Shigeki Suzuki (661339)

“…The bound biotinylated GRGDS peptide was valued using a streptavidin-HRP conjugated polymer. Dose-dependent decreases in biotinylated GRGDS binding to integrin αvβ3 were regressed to a sigmoid curve. …”

Data_Sheet_1_Lung Tissue Microbiome Is Associated With Clinical Outcomes of Idiopathic Pulmonary Fibrosis.docx by Hee-Young Yoon (5696522)

“…A decreased relative abundance of Pelomonas (odds ratio [OR], 0.352, p = 0.027) and Azonexus (OR, 0.013, p = 0.046) was associated with a diagnosis of IPF in the multivariable logistic analysis adjusted by age and gender. …”

Importance of boundary conditions. by Cécile M. Bidan (165026)

“…Each initial interface (black) contains a semi-circle with a radius of 0.5 mm. The different boundary conditions show the influence expected on tissue growth rate and organisation. …”

Data_Sheet_1_Wearing-off Identification in Parkinson's Disease: The shapd-woq Study.docx by Ying Wan (118747)

“…The mean age was 69.7 ± 9.5 years and the mean disease duration was 5.8 ± 4.7 years. …”

Image_1_Effect of Humic Acid Addition on Buffering Capacity and Nutrient Storage Capacity of Soilless Substrates.TIF by Jingcheng Xu (1356810)

“…<p>Excessive application of fertilizers has become a major issue in croplands of intensive agricultural systems in China, resulting in severe non-point source pollution; thus, reduction in the use of chemical fertilizers has received significant attention. …”

Re-aware Global Ocean Deoxygenation During the Past 140 Years by Zhenhong Du (8131703)

“…Our quantitative analyses revealed a decline in global ocean oxygen content from 234.5 ± 0.4 Pmol in 1871 to 230.6 ± 0.4 Pmol in 2010, with a sharp drop of −1402.2 ± 173.6 Tmol per decade post-1980, attributing 98.5% of total oxygen loss in the past three decades alone. …”

Contribution of core Atgs to autophagy of GFP-Snc1-PEM. by Zhanna Lipatova (771232)

“…<p><b>A-C.</b> Atg5 and Atg7 are required for constitutive ER-phagy. …”

Pearson correlation between various aspects of selenocysteine insertion sequences from the seed alignment of Rfam family RF00031 [23]. by Evan Senter (110590)

“…However, it may appear surprising that <i>(v)</i> the mean number of base pairs per structure is independent of MFPT (correlation ), although <i>(vi)</i> MFE is correlated with MFPT (correlation ) – i.e. from <i>(iii)</i>, lower MFE is correlated with a larger average number of base pairs per structure, from <i>(vi)</i> higher MFE is correlated with longer folding time, but from <i>(v)</i> the average number of base pairs per structure is independent of folding time. …”