Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Ariadne is a non-hallucinogenic analog in the phenylalkylamine chemical class of psychedelics that is closely related to an established synthetic hallucinogen, 2,5-dimethoxy-4-methyl-amphetamine (DOM), differing only by one methylene group in the α-position to the amine. …”

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Ariadne is a non-hallucinogenic analog in the phenylalkylamine chemical class of psychedelics that is closely related to an established synthetic hallucinogen, 2,5-dimethoxy-4-methyl-amphetamine (DOM), differing only by one methylene group in the α-position to the amine. …”

Video1_Unexpected decrease of full-length prion protein in macaques inoculated with prion-contaminated blood products.MP4 by Nina Jaffré (15415058)

Preincubation with papaverine leads to decreases in phosphorylation of the myosin light chain in HSV. by Kyle M. Hocking (402156)

Predicted BMI growth trajectories for ALSPAC boys and girls from birth to age 18 years for GRS = 2.5 and 7.5, and (a) EBF = 0 or 5 months, and (b) BF = 0 or 5 months. by Yanyan Wu (1474534)

Subjects:

Invasion of <i>P. falciparum</i> strain Dd2 decreases as untreated RBCs are replaced with enzyme treated RBCs. by Martha A. Clark (322102)

Cardamonin decreased the expression of lipogenic proteins. by Peiguang Niu (17044532)

A DNA-PKcs-specific inhibitor decreases HBoV1 infection of HAE-ALI. by Xuefeng Deng (138723)

<i>ATP5E</i> promoter DNA methylation by MetS status. by Keane Urashima (11625020)

Subjects:

Knockdown of AR expression decreases the efficiency of KSHV infection in endothelial cells. by Xing Wang (154377)

“…(g, h) Knockdown of AR and EphA2 expression decreases nuclear LANA expression in SLK cells, as determined by an immunofluorescence assay and quantitative analysis by Image J software. …”

Predictions of random forests (RF), gradient boosting machines (GBM), and neural networks (NN) trained on 12 covariates chosen using subjective feature selection. by Dennis Ochola (11626912)

Subjects:

Predictions of random forests (RF), gradient boosting machines (GBM), and neural networks (NN) trained on 17 covariates selected after recursive feature selection. by Dennis Ochola (11626912)

Subjects:

Theme 5 results—mortality. by Corey J. A. Bradshaw (8032406)

Decreased Polycystin 2 Levels Result in Non-Renal Cardiac Dysfunction with Aging by Ivana Y. Kuo (707543)

“…Anatomically, the 9 month old Pkd2+/- mice had thinner left ventricular walls, consistent with dilated cardiomyopathy, and the left ventricular ejection fraction was decreased. Intriguingly, in response to acute isoproterenol stimulation to examine β-adrenergic responses, the 9 month old Pkd2+/- mice exhibited a stronger contractile response, which also coincided with preserved localization of the β2 adrenergic receptor. …”

Decreasing ShcA expression enhances TGF-β-induced Smad signaling. by Baby Periyanayaki Muthusamy (838234)

“…The error bars show standard error of the mean, based on three independent experiments. Supplemental data are shown in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002325#pbio.1002325.s006" target="_blank">S5 Fig</a> and <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002325#pbio.1002325.s001" target="_blank">S1 Data</a>.…”

Probiotic effects of <i>P. acnes</i> fermentation against USA300 accompanied by a decrease in intracellular pH. by Muya Shu (124300)

<i>neurod1</i>^<i>ΔUCE</i> homozygous mutants display a decrease in the expression of several EE hormones. by Anne Sophie Reuter (12239993)

Percentage decrease in model output peak with the administration of exogenous estrogen/progesterone. by Brenda Lyn A. Gavina (15285185)

Data_Sheet_1_Effectiveness of non-pharmaceutical interventions in nine fields of activity to decrease SARS-CoV-2 transmission (Spain, September 2020–May 2021).PDF by Inés Barbeito (5864351)

“…In a reduced model with seven fields, culture and leisure no longer had a significant effect while ceremonies decreased transmission by 5% (0.95; 0, 0.96). …”

Evidence of decreased system justification among extreme conservatives in non-American samples by Luca Caricati (6259799)