Vasodilator effect of BPP-BrachyNH₂ and captopril (10⁻⁹–3 × 10⁻⁵ M) on rat thoracic aorta. by Daniel Dias Rufino Arcanjo (536744)

Transfer of RSV-infected <i>Kdm5b</i>-deficient DCs leads to a decreased pathogenic pulmonary RSV challenge. by Catherine Ptaschinski (756139)

AIM-100 reduces dsRNA silencing in body wall muscle and decreases DA neurodegeneration. by Anthony L. Gaeta (13272609)

<b>When more isn’t better: Sperm competition decreases fertilization success and motile sperm in two sea urchin species</b> by Luisa Kumpitsch (20874095)

Oleanolic acid (OA) decreases cell viability and induces apoptosis of non-small cell lung cancer cell lines. by Kelly Araújo Lúcio (337774)

A non-significant decrease in time to peak desaturation was found post training; P = 0.07, ES = 0.53 ± 0.46. by Ben Jones (554472)

TIRF analyses of pericentrin-depleted MIN6 cells at non-stimulatory glucose concentration (2.5 mM) show increase in docked insulin granules and decrease at stimulatory glucose concentration (25 mM). by Agata Jurczyk (245201)

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

The novel <i>carboxylesterase 1</i> variant c.662A>G may decrease the bioactivation of oseltamivir in humans by Jaeseong Oh (3947381)

“…A novel <i>CES1</i> c.662A>G single nucleotide polymorphism (SNP) was predicted to decrease CES1 enzymatic activity in an <i>in silico</i> analysis. …”

<i>SIRT6</i> Minor Allele Genotype Is Associated with >5-Year Decrease in Lifespan in an Aged Cohort by Mindi J. TenNapel (679433)

Brain and liver GCase activity are significantly decreased in heterozygous <i>GBA1</i> D409V KI mice, with varying differences in glucosphingolipid lipids in brain and liver. by Nicole K. Polinski (10947787)

“…(A-B) GCase levels as assessed by the CBE/4-MU method are significantly decreased in the het <i>GBA1</i> D409V KI mice at 5 months of age in both brain (A) and liver (B). …”

Microinjection of morphine in rat rostromedial tegmental nucleus (RMTg) decreased non-rapid eye movement (NREM) sleep in a dose-dependent manner. by Su-Rong Yang (467756)

Cell surface CHT levels are unchanged by altered PI3-Kinase signaling in non-depolarized cells. by Katherine J. Fishwick (768451)

Time course of central retinal thickness (CRT) in recurrence and non-recurrence groups. by Yasuyuki Sotani (20114144)

“…These values significantly decreased in the first postoperative year to 2.3 ± 2.6, 0.1 ± 0.3, 0.8 ± 1.6, 0, and 3.1 ± 2.8; in the second year to 2.1 ± 2.8, 0.4 ± 1.0, 0.0, 0.1 ± 0.3, and 2.6 ± 2.8; and in the third year to 2.0 ± 2.2, 0, 0.6 ± 1.7, 0.1 ± 0.3, and 2.8 ± 3.5 (Kruskal–Wallis test, p < 0.001; <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0332941#pone.0332941.g007" target="_blank">Fig 7</a>). …”

Panel (a) shows ensemble mean global mean near-surface air temperature in historical and RCP simulations from CanESM2 by Nathan P Gillett (557010)

“…Shaded bands show estimates of the 5–95% uncertainty ranges in the ensemble mean ratios, derived by taking the standard deviation of the ratio from each of the five independent pairs of simulations with and without aerosol changes, dividing by the square root of five (the ensemble size), and multiplying by a Student-<em>t</em> statistic with a cutoff value of 0.05 and four degrees of freedom (one less than the ensemble size). …”

ND-75^KD flies have reduced mobility, seizures and decreased lifespan. by Lucy Granat (5570813)

GSPs decrease cell viability and induce cell death of HNSCC cells. by Ram Prasad (305524)

Inhibition of VEGF-A gene synthesis decreased ranibizumab and aflibercept mediated CCL2 CCL5, and CX3CL1 mRNA and protein levels in HCAECs. by Clare Arnott (2557705)

Glucagon receptor (GcgR) antagonism decrease α-cell proliferation. by Zhuo Liu (357070)